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Flavonoids Can Protect Maize DNA from the Induction of Ultraviolet Radiation Damage
Open accessAbstract
Diverse flavonoid compounds are widely distributed in angiosperm families. Flavonoids absorb radiation in the ultraviolet (UV) region of the spectrum, and it has been proposed that these compounds function as UV filters. We demonstrate that the DNA in Zea mays plants that contain flavonoids (primarily anthocyanins) is protected from the induction of damage caused by UV radiation relative to the DNA in plants that are genetically deficient in these compounds. DNA damage was measured with a sensitive and simple assay using individual monoclonal antibodies, one specific for cyclobutane pyrimidine dimer damage and the other specific for pyrimidine(6,4)pyrimidone damage.
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“To avoid the deleterious effects of UVR, plants have acquired two main protective strategies; shielding by flavonoids and phenolic compounds [168, 169] and DNA repair by photoreactivation.”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [168]
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“To avoid the deleterious effects of UVR, plants have acquired two main protective strategies; shielding by flavonoids and phenolic compounds [168, 169] and DNA repair by photoreactivation.”
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Metadata
- Authors
- Stapleton, A. E., & Walbot, V.
- Affiliations
- Stanford University (US)
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-07-01
- Volume
- 105
- Issue
- 3
- Pages
- 881-889
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- PMC
- PMC160736
- OpenAlex
- W2120833079
- Cited by
- 420
- References
- 41
- Citations by year
- 2026: 1 · 2025: 13 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 14 · 2016: 14 · 2015: 15 · 2014: 9 · 2013: 10 · 2012: 18
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PLANT PHYSIOLOGY (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32es005545-01)
- National Institute of Environmental Health Sciences (F32 ES05545)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Keywords
- flavonoids, anthocyanins, maize, ultraviolet radiation, DNA damage, UV protection, cyclobutane pyrimidine dimers, monoclonal antibodies, UV filters
- MeSH terms
- Anthocyanins, Zea mays, DNA, DNA Damage, Dose-Response Relationship, Radiation, Flavonoids, Kinetics, Ultraviolet Rays
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