The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
AtHMA3, a P1B-ATPase Allowing Cd/Zn/Co/Pb Vacuolar Storage in Arabidopsis
Open accessAbstract
The Arabidopsis (Arabidopsis thaliana) Heavy Metal Associated3 (AtHMA3) protein belongs to the P1B-2 subgroup of the P-type ATPase family, which is involved in heavy metal transport. In a previous study, we have shown, using heterologous expression in the yeast Saccharomyces cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1. In this study, we demonstrate that AtHMA3 in planta is located in the vacuolar membrane, with a high expression level in guard cells, hydathodes, vascular tissues, and the root apex. Confocal imaging in the presence of the Zn/Cd fluorescent probe BTC-5N revealed that AtHMA3 participates in the vacuolar storage of Cd. A T-DNA insertional mutant was found more sensitive to Zn and Cd. Conversely, ectopic overexpression of AtHMA3 improved plant tolerance to Cd, cobalt, Pb, and Zn; Cd accumulation increased by about 2- to 3-fold in plants overexpressing AtHMA3 compared with wild-type plants. Thus, AtHMA3 likely plays a role in the detoxification of biological (Zn) and nonbiological (Cd, cobalt, and Pb) heavy metals by participating in their vacuolar sequestration, an original function for a P1B-2 ATPase in a multicellular eukaryote.
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Cites
Molecular mechanisms of plant metal tolerance and homeostasis
Clemens, S. (2001) · Planta · doi:10.1007/s004250000458 · Cited by 1,417
A long way ahead: understanding and engineering plant metal accumulation
Clemens, S., Palmgren, M. G., & Krämer, U. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02295-1 · Cited by 1,265
The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens
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Becher, M., Talke, I. N., Krall, L., & Krämer, U. (2004) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01959.x · Cited by 568
The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
Rensing, C., Mitra, B., & Rosen, B. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14326 · Cited by 419
Cited by
Root responses to cadmium in the rhizosphere: a review
Lux, A., Martinka, M., Vaculik, M., & White, P. J. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/erq281 · Cited by 1,100
Approaches for enhanced phytoextraction of heavy metals
Bhargava, A., Carmona, F. F., Bhargava, M., & Srivastava, S. (2012) · Journal of Environmental Management · doi:10.1016/j.jenvman.2012.04.002 · Cited by 586
Kang, J., Park, J., Choi, H., Burla, B., Kretzschmar, T., Lee, Y., & Martinoia, E. (2011) · The Arabidopsis Book · doi:10.1199/tab.0153 · Cited by 573
The zinc homeostasis network of land plants
Sinclair, S. A., & Krämer, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.016 · Cited by 502
Mendoza-Cózatl, D. G., Jobe, T. O., Hauser, F., & Schroeder, J. I. (2011) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2011.07.004 · Cited by 435
Metadata
- Authors
- Morel, M., Crouzet, J., Gravot, A., Auroy, P., Leonhardt, N., Vavasseur, A., & Richaud, P.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11-26
- Volume
- 149
- Issue
- 2
- Pages
- 894-904
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W2105052969
- Cited by
- 671
- References
- 6
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Morel, M., Crouzet, J., Gravot, A., Auroy, P., Leonhardt, N., Vavasseur, A., & Richaud, P. (2009). AtHMA3, a P1B-ATPase Allowing Cd/Zn/Co/Pb Vacuolar Storage in Arabidopsis. Plant Physiology. https://doi.org/10.1104/pp.108.130294
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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