The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Arabidopsis SENESCENCE-ASSOCIATED GENE101 Stabilizes and Signals within an ENHANCED DISEASE SUSCEPTIBILITY1 Complex in Plant Innate Immunity
Open accessAbstract
Plant innate immunity against invasive biotrophic pathogens depends on the intracellular defense regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1). We show here that Arabidopsis thaliana EDS1 interacts in vivo with another protein, SENESCENCE-ASSOCIATED GENE101 (SAG101), discovered through a proteomic approach to identify new EDS1 pathway components. Together with PHYTOALEXIN-DEFICIENT4 (PAD4), a known EDS1 interactor, SAG101 contributes intrinsic and indispensable signaling activity to EDS1-dependent resistance. The combined activities of SAG101 and PAD4 are necessary for programmed cell death triggered by the Toll-Interleukin-1 Receptor type of nucleotide binding/leucine-rich repeat immune receptor in response to avirulent pathogen isolates and in restricting the growth of normally virulent pathogens. We further demonstrate by a combination of cell fractionation, coimmunoprecipitation, and fluorescence resonance energy transfer experiments the existence of an EDS1–SAG101 complex inside the nucleus that is molecularly and spatially distinct from EDS1–PAD4 associations in the nucleus and cytoplasm. By contrast, EDS1 homomeric interactions were detected in the cytoplasm but not inside the nucleus. These data, combined with evidence for coregulation between individual EDS1 complexes, suggest that dynamic interactions of EDS1 and its signaling partners in multiple cell compartments are important for plant defense signal relay.
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Self-citationArabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling
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Cited by
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Self-citationPathogen Effectors Target Arabidopsis EDS1 and Alter Its Interactions with Immune Regulators
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Metadata
- Authors
- Feys, B. J., Wiermer, M., Bhat, R. A., Moisan, L. J., Medina-Escobar, N., Neu, C., Cabral, A., & Parker, J. E.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-07-22
- Volume
- 17
- Issue
- 9
- Pages
- 2601-2613
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2104525554
- Cited by
- 455
- References
- 26
- FWCI
- 22.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Feys, B. J., Wiermer, M., Bhat, R. A., Moisan, L. J., Medina-Escobar, N., Neu, C., Cabral, A., & Parker, J. E. (2005). Arabidopsis SENESCENCE-ASSOCIATED GENE101 Stabilizes and Signals within an ENHANCED DISEASE SUSCEPTIBILITY1 Complex in Plant Innate Immunity. The Plant Cell. https://doi.org/10.1105/tpc.105.033910
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