The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Targeted Degradation of PSEUDO-RESPONSE REGULATOR5 by an SCF ZTL Complex Regulates Clock Function and Photomorphogenesis in Arabidopsis thaliana
Open accessAbstract
Circadian clocks comprise several regulatory feedback loops that control gene transcription. However, recent evidence has shown that posttranslational mechanisms are also required for clock function. In Arabidopsis thaliana, members of the PSEUDO-RESPONSE REGULATOR (PRR) family were proposed to be components of the central oscillator. Using a PRR5-specific antibody, we characterized changes in PRR5 protein levels in relation to its mRNA levels under various circadian conditions. Under long-day conditions, PRR5 mRNA levels are undetectable at dusk but PRR5 protein levels remain maximal. Upon dark transition, however, PRR5 levels decrease rapidly, indicating dark-induced, posttranslational regulation. We demonstrated that the Pseudo-Receiver (PR) domain of PRR5 interacts directly with the F box protein ZEITLUPE (ZTL) in vitro and in vivo. Analyses of mutants and transgenic plants revealed an inverse correlation between PRR5 and ZTL levels, which depends on the PR domain. These results indicate that PRR5 is negatively regulated by ZTL, which likely mediates its ubiquitination and degradation. Phenotypic analyses of prr5 ztl double mutants showed that PRR5 is required for ZTL functions. ZTL contains a Light-Oxygen-Voltage domain, and its activity may be directly regulated by blue light. Consistent with this notion, we found that blue light stabilizes PRR5, although it does not alter ZTL levels. Together, our results show that ZTL targets PRR5 for degradation by 26S proteasomes in the circadian clock and in early photomorphogenesis.
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Cites
Agrobacterium-mediated transformation of Arabidopsis thaliana using the floral dip method
Zhang, X., Henriques, R., Lin, S.-S., Niu, Q.-W., & Chua, N.-H. (2006) · Nature Protocols · doi:10.1038/nprot.2006.97 · Cited by 2,335
Self-citationPlant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage
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phot1 and phot2 mediate blue light regulation of stomatal opening
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BackgroundInfluentialCloning of the Arabidopsis Clock Gene TOC1 , an Autoregulatory Response Regulator Homolog
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FKF1 F-Box Protein Mediates Cyclic Degradation of a Repressor of CONSTANS in Arabidopsis
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ZEITLUPE Encodes a Novel Clock-Associated PAS Protein from Arabidopsis
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LHY and CCA1 Are Partially Redundant Genes Required to Maintain Circadian Rhythms in Arabidopsis
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FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis
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Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana
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Cited by
Light-Regulated Plant Growth and Development
Kami, C., Lorrain, S., Hornitschek, P., & Fankhauser, C. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)91002-8 · Cited by 927
Lezhneva, L., Kiba, T., Feria‐Bourrellier, A., Lafouge, F., Boutet‐Mercey, S., Zoufan, P., Sakakibara, H., Daniel‐Vedele, F., & Krapp, A. (2014) · The Plant Journal · doi:10.1111/tpj.12626 · Cited by 369
Self-citationCircadian Clock and Photoperiodic Flowering in Arabidopsis: CONSTANS Is a Hub for Signal Integration
Shim, J. S., Kubota, A., & Imaizumi, T. (2017) · Plant Physiology · doi:10.1104/pp.16.01327 · Cited by 359
Shade avoidance: phytochrome signalling and other aboveground neighbour detection cues
Pierik, R., & de Wit, M. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/ert389 · Cited by 298
Plant Flavoprotein Photoreceptors
Christie, J. M., Blackwood, L., Petersen, J., & Sullivan, S. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcu196 · Cited by 294
Metadata
- Authors
- Kiba, T., Henriques, R., Sakakibara, H., & Chua, N.-H.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08
- Volume
- 19
- Issue
- 8
- Pages
- 2516-2530
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2014034577
- Cited by
- 261
- References
- 50
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Kiba, T., Henriques, R., Sakakibara, H., & Chua, N.-H. (2007). Targeted Degradation of PSEUDO-RESPONSE REGULATOR5 by an SCF ZTL Complex Regulates Clock Function and Photomorphogenesis in Arabidopsis thaliana. The Plant Cell. https://doi.org/10.1105/tpc.107.053033
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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