The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Highly Similar Arabidopsis Homologs of Trithorax ATX1 and ATX2 Encode Proteins with Divergent Biochemical Functions
Open accessAbstract
Gene duplication followed by functional specialization is a potent force in the evolution of biological diversity. A comparative study of two highly conserved duplicated genes, ARABIDOPSIS TRITHORAX-LIKE PROTEIN1 (ATX1) and ATX2, revealed features of both partial redundancy and of functional divergence. Although structurally similar, their regulatory sequences have diverged, resulting in distinct temporal and spatial patterns of expression of the ATX1 and ATX2 genes. We found that ATX2 methylates only a limited fraction of nucleosomes and that ATX1 and ATX2 influence the expression of largely nonoverlapping gene sets. Even when coregulating shared targets, ATX1 and ATX2 may employ different mechanisms. Most remarkable is the divergence of their biochemical activities: both proteins methylate K4 of histone H3, but while ATX1 trimethylates it, ATX2 dimethylates it. ATX2 and ATX1 provide an example of separated K4 di from K4 trimethyltransferase activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845 · cited 1×
“The highly conserved SET peptide [for Su(var)3-9, E(z), Trithorax], encoded by the Drosophila melanogaster Su(var)39-, E(z)-, and Trithorax-related genes, carries histone lysine methyltransferase (HKMT) activity with a preference for specific histone residue substrates (Rea et al., 2000).”
BackgroundActive Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
Ruthenburg, A. J., Allis, C. D., & Wysocka, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.014 · Cited by 1,147
A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome
Blanc, G., Hokamp, K., & Wolfe, K. H. (2003) · Genome Research · doi:10.1101/gr.751803 · Cited by 724
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Hayashi, K., Yoshida, K., & Matsui, Y. (2005) · Nature · doi:10.1038/nature04112 · Cited by 472
Cited by
Lämke, J., & Bäurle, I. (2017) · Genome Biology · doi:10.1186/s13059-017-1263-6 · Cited by 893
Saleh, A., Alvarez-Venegas, R., & Avramova, Z. (2008) · Nature Protocols · doi:10.1038/nprot.2008.66 · Cited by 641
Self-citationEpigenetic regulation in plant abiotic stress responses
Chang, Y., Zhu, C., Jiang, J., Zhang, H., Zhu, J., & Duan, C. (2020) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12901 · Cited by 533
Histone Modifications in Transcriptional Activation during Plant Development
Berr, A., Shafiq, S., & Shen, W.-H. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.07.001 · Cited by 251
Epigenetic variation as a new plant breeding tool: A review
Alfalahi, A. O., Hussein, Z. T., Khalofah, A., Sadder, M. T., Qasem, J. R., Al-Khayri, J. M., Jain, S. M., & Almehemdi, A. F. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.102302 · Cited by 23
Self-citation
Metadata
- Authors
- Saleh, A., Alvarez-Venegas, R., Yilmaz, M., Le, O., Hou, G., Sadder, M., Al-Abdallat, A., Xia, Y., Lu, G., Ladunga, I., & Avramova, Z.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-03-01
- Volume
- 20
- Issue
- 3
- Pages
- 568-579
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2104466885
- Cited by
- 201
- References
- 7
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Highly Similar Arabidopsis Homologs of Trithorax ATX1 and ATX2 Encode Proteins with Divergent Biochemical Functions. https://app.cochat.ai/papers/10.1105/tpc.107.056614
- The paper
- Saleh, A., Alvarez-Venegas, R., Yilmaz, M., Le, O., Hou, G., Sadder, M., Al-Abdallat, A., Xia, Y., Lu, G., Ladunga, I., & Avramova, Z. (2008). The Highly Similar Arabidopsis Homologs of Trithorax ATX1 and ATX2 Encode Proteins with Divergent Biochemical Functions. The Plant Cell. https://doi.org/10.1105/tpc.107.056614
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
