The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The Arabidopsis Leucine-Rich Repeat Receptor–Like Kinases BAK1/SERK3 and BKK1/SERK4 Are Required for Innate Immunity to Hemibiotrophic and Biotrophic Pathogens
Open accessAbstract
Recognition of pathogen-associated molecular patterns (PAMPs) by surface-localized pattern recognition receptors (PRRs) constitutes an important layer of innate immunity in plants. The leucine-rich repeat (LRR) receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN SENSING2 (FLS2) are the PRRs for the peptide PAMPs elf18 and flg22, which are derived from bacterial EF-Tu and flagellin, respectively. Using coimmunoprecipitation and mass spectrometry analyses, we demonstrated that EFR and FLS2 undergo ligand-induced heteromerization in planta with several LRR receptor-like kinases that belong to the SOMATIC-EMBRYOGENESIS RECEPTOR-LIKE KINASE (SERK) family, including BRASSINOSTEROID INSENSITIVE1-ASSOCIATED KINASE1/SERK3 (BAK1/SERK3) and BAK1-LIKE1/SERK4 (BKK1/SERK4). Using a novel bak1 allele that does not exhibit pleiotropic defects in brassinosteroid and cell death responses, we determined that BAK1 and BKK1 cooperate genetically to achieve full signaling capability in response to elf18 and flg22 and to the damage-associated molecular pattern AtPep1. Furthermore, we demonstrated that BAK1 and BKK1 contribute to disease resistance against the hemibiotrophic bacterium Pseudomonas syringae and the obligate biotrophic oomycete Hyaloperonospora arabidopsidis. Our work reveals that the establishment of PAMP-triggered immunity (PTI) relies on the rapid ligand-induced recruitment of multiple SERKs within PRR complexes and provides insight into the early PTI signaling events underlying this important layer of plant innate immunity.
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Cites
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
Boller, T., & Felix, G. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105346 · Cited by 3,387
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Zipfel, C., Kunze, G., Chinchilla, D., Caniard, A., Jones, J. D. G., Boller, T., & Felix, G. (2006) · Cell · doi:10.1016/j.cell.2006.03.037 · Cited by 2,064
Self-citationPlant Stomata Function in Innate Immunity against Bacterial Invasion
Melotto, M., Underwood, W., Koczan, J., Nomura, K., & He, S. Y. (2006) · Cell · doi:10.1016/j.cell.2006.06.054 · Cited by 1,981
A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nürnberger, T., Jones, J. D. G., Felix, G., & Boller, T. (2007) · Nature · doi:10.1038/nature05999 · Cited by 1,923
Self-citationBacterial disease resistance in Arabidopsis through flagellin perception
Zipfel, C., Robatzek, S., Navarro, L., Oakeley, E. J., Jones, J. D. G., Felix, G., & Boller, T. (2004) · Nature · doi:10.1038/nature02485 · Cited by 1,790
Self-citationPlants have a sensitive perception system for the most conserved domain of bacterial flagellin
Felix, G., Duran, J. D., Volko, S., & Boller, T. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00265.x · Cited by 1,715
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Cited by
Pattern-recognition receptors are required for NLR-mediated plant immunity
Yuan, M., Jiang, Z., Bi, G., Nomura, K., Liu, M., Wang, Y., Cai, B., Zhou, J.-M., He, S. Y., & Xin, X.-F. (2021) · Nature · doi:10.1038/s41586-021-03316-6 · Cited by 1,257
PTI-ETI crosstalk: an integrative view of plant immunity
Yuan, M., Ngou, B. P. M., Ding, P., & Xin, X.-F. (2021) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2021.102030 · Cited by 915
Plant cell wall‐mediated immunity: cell wall changes trigger disease resistance responses
Bacete, L., Mélida, H., Miedes, E., & Molina, A. (2018) · The Plant Journal · doi:10.1111/tpj.13807 · Cited by 659
Regulation of the NADPH Oxidase RBOHD During Plant Immunity
Kadota, Y., Shirasu, K., & Zipfel, C. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv063 · Cited by 641
Self-citationThe role of the cell wall in plant immunity
Malinovsky, F. G., Fangel, J. U., & Willats, W. G. T. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00178 · Cited by 555
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Metadata
- Authors
- Roux, M., Schwessinger, B., Albrecht, C., Chinchilla, D., Jones, A., Holton, N., Malinovsky, F. G., Tör, M., de Vries, S., & Zipfel, C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-01
- Volume
- 23
- Issue
- 6
- Pages
- 2440-2455
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2170636855
- Cited by
- 699
- References
- 53
- FWCI
- 55.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Roux, M., Schwessinger, B., Albrecht, C., Chinchilla, D., Jones, A., Holton, N., Malinovsky, F. G., Tör, M., de Vries, S., & Zipfel, C. (2011). The Arabidopsis Leucine-Rich Repeat Receptor–Like Kinases BAK1/SERK3 and BKK1/SERK4 Are Required for Innate Immunity to Hemibiotrophic and Biotrophic Pathogens. The Plant Cell. https://doi.org/10.1105/tpc.111.084301
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