The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
AGAMOUS Terminates Floral Stem Cell Maintenance in Arabidopsis by Directly Repressing WUSCHEL through Recruitment of Polycomb Group Proteins
Open accessAbstract
Floral stem cells produce a defined number of floral organs before ceasing to be maintained as stem cells. Therefore, floral stem cells offer an ideal model to study the temporal control of stem cell maintenance within a developmental context. AGAMOUS (AG), a MADS domain transcription factor essential for the termination of floral stem cell fate, has long been thought to repress the stem cell maintenance gene WUSCHEL (WUS) indirectly. Here, we uncover a role of Polycomb Group (PcG) genes in the temporally precise repression of WUS expression and termination of floral stem cell fate. We show that AG directly represses WUS expression by binding to the WUS locus and recruiting, directly or indirectly, PcG that methylates histone H3 Lys-27 at WUS. We also show that PcG acts downstream of AG and probably in parallel with the known AG target KNUCKLES to terminate floral stem cell fate. Our studies identify core components of the network governing the temporal program of floral stem cells.
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Cites
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×
“Increasing evidence points to the involvement of noncoding RNAs in PcG recruitment to targets in animals and plants (Rinn et al., 2007; Zhao et al., 2008; Khalil et al., 2009; Kanhere et al., 2010; Tsai et al., 2010; Yap et al., 2010; Heo and Sung, 2011).”
BackgroundKhalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Early flower development in Arabidopsis.
Smyth, D. R., Bowman, J. L., & Meyerowitz, E. M. (1990) · The Plant Cell · doi:10.1105/tpc.2.8.755 · Cited by 2,155
A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
Long, J. A., Moan, E. I., Medford, J. I., & Barton, M. K. (1996) · Nature · doi:10.1038/379066a0 · Cited by 1,537
Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391
Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis
Zhang, X., Clarenz, O., Cokus, S., Bernatavichute, Y. V., Pellegrini, M., Goodrich, J., & Jacobsen, S. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050129 · Cited by 767
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Cited by
Engineering Quantitative Trait Variation for Crop Improvement by Genome Editing
Rodríguez-Leal, D., Lemmon, Z. H., Man, J., Bartlett, M. E., & Lippman, Z. B. (2017) · Cell · doi:10.1016/j.cell.2017.08.030 · Cited by 1,159
Plant regeneration: cellular origins and molecular mechanisms
Ikeuchi, M., Ogawa, Y., Iwase, A., & Sugimoto, K. (2016) · Development · doi:10.1242/dev.134668 · Cited by 592
A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration
Zhang, T.-Q., Lian, H., Zhou, C.-M., Xu, L., Jiao, Y., & Wang, J.-W. (2017) · The Plant Cell · doi:10.1105/tpc.16.00863 · Cited by 357
The Polycomb Group Protein Regulatory Network
Mozgova, I., & Hennig, L. (2015) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043014-115627 · Cited by 302
Metadata
- Authors
- Liu, X., Kim, Y. J., Müller, R., Yumul, R. E., Liu, C., Pan, Y., Cao, X., Goodrich, J., & Chen, X.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-10-01
- Volume
- 23
- Issue
- 10
- Pages
- 3654-3670
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2140643779
- Cited by
- 303
- References
- 6
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Liu, X., Kim, Y. J., Müller, R., Yumul, R. E., Liu, C., Pan, Y., Cao, X., Goodrich, J., & Chen, X. (2011). AGAMOUS Terminates Floral Stem Cell Maintenance in Arabidopsis by Directly Repressing WUSCHEL through Recruitment of Polycomb Group Proteins. The Plant Cell. https://doi.org/10.1105/tpc.111.091538
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