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Cited by 630

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Ion Exchangers NHX1 and NHX2 Mediate Active Potassium Uptake into Vacuoles to Regulate Cell Turgor and Stomatal Function in Arabidopsis

Open access
Barragán, Verónica, Leidi, Eduardo O., Andrés, Zaida, Rubio, Lourdes, De Luca, Anna, Fernández, José A., Cubero, Beatriz, Pardo, José M.·2012·The Plant Cell
DOI 10.1105/tpc.111.095273
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Abstract

Intracellular NHX proteins are Na(+),K(+)/H(+) antiporters involved in K(+) homeostasis, endosomal pH regulation, and salt tolerance. Proteins NHX1 and NHX2 are the two major tonoplast-localized NHX isoforms. Here, we show that NHX1 and NHX2 have similar expression patterns and identical biochemical activity, and together they account for a significant amount of the Na(+),K(+)/H(+) antiport activity in tonoplast vesicles. Reverse genetics showed functional redundancy of NHX1 and NHX2 genes. Growth of the double mutant nhx1 nhx2 was severely impaired, and plants were extremely sensitive to external K(+). By contrast, nhx1 nhx2 mutants showed similar sensitivity to salinity stress and even greater rates of Na(+) sequestration than the wild type. Double mutants had reduced ability to create the vacuolar K(+) pool, which in turn provoked greater K(+) retention in the cytosol, impaired osmoregulation, and compromised turgor generation for cell expansion. Genes NHX1 and NHX2 were highly expressed in guard cells, and stomatal function was defective in mutant plants, further compromising their ability to regulate water relations. Together, these results show that tonoplast-localized NHX proteins are essential for active K(+) uptake at the tonoplast, for turgor regulation, and for stomatal function.

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Metadata

Authors
Barragán, V., Leidi, E. O., Andrés, Z., Rubio, L., De Luca, A., Fernández, J. A., Cubero, B., & Pardo, J. M.
Venue
The Plant Cell
Publisher
Oxford University Press (OUP)
Published
2012-03
Volume
24
Issue
3
Pages
1127-1142
ISSN
  • 1040-4651 (ISSN-L)
  • 1532-298X
DOI
10.1105/tpc.111.095273
OpenAlex
W2114149804
Cited by
630
References
54
FWCI
34.07
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Ion Exchangers NHX1 and NHX2 Mediate Active Potassium Uptake into Vacuoles to Regulate Cell Turgor and Stomatal Function in Arabidopsis. https://app.cochat.ai/papers/10.1105/tpc.111.095273
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Barragán, V., Leidi, E. O., Andrés, Z., Rubio, L., De Luca, A., Fernández, J. A., Cubero, B., & Pardo, J. M. (2012). Ion Exchangers NHX1 and NHX2 Mediate Active Potassium Uptake into Vacuoles to Regulate Cell Turgor and Stomatal Function in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.111.095273

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