The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation
Open accessAbstract
The homeodomain transcription factor WUSCHEL (WUS) defines the shoot stem cell niche, but the mechanisms underlying the establishment of WUS expression remain unclear. Here, we show that cytokinin signaling precedes WUS expression in leaf axils and activates WUS expression de novo in the leaf axil to promote axillary meristem initiation. Furthermore, type-B Arabidopsis response regulator proteins, which are transcriptional activators in the cytokinin signaling pathway, directly bind to the WUS promoter and activate its expression. Finally, we show that cytokinin activation of WUS in the leaf axil correlates with increased histone acetylation and methylation markers associated with transcriptional activation, supporting the fact that WUS expression requires a permissive epigenetic environment to restrict it to highly defined meristematic tissues. Taken together, these findings explain how cytokinin regulates axillary meristem initiation and establish a mechanistic framework for the postembryonic establishment of the shoot stem cell niche.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Evolutionary divergence and convergence in proteins.
ZUCKERKANDL, E., & PAULING, L. (1965) · Evolving Genes and Proteins · doi:10.1016/b978-1-4832-2734-4.50017-6 · Cited by 3,020
Greb, T., Clarenz, O., Schäfer, E., Müller, D., Herrero, R., Schmitz, G., & Theres, K. (2003) · Genes & Development · doi:10.1101/gad.260703 · Cited by 541 · cited 8×
“Expression of the meristematic cell marker STM is maintained in las and rev mutants (Greb et al., 2003; Shi et al., 2016), suggesting that at least partial AM progenitor cell specification occurs in these mutants.”
BackgroundInfluentialTalbert, P. B., Adler, H. T., Parks, D. W., & Comai, L. (1995) · Development · doi:10.1242/dev.121.9.2723 · Cited by 365
Initiation of Axillary and Floral Meristems in Arabidopsis
Long, J., & Barton, M. K. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9572 · Cited by 357
McSteen, P., & Leyser, O. (2005) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.56.032604.144122 · Cited by 356
Reddy, G. V., Heisler, M. G., Ehrhardt, D. W., & Meyerowitz, E. M. (2004) · Development · doi:10.1242/dev.01261 · Cited by 339
Blind Homologous R2R3 Myb Genes Control the Pattern of Lateral Meristem Initiation in Arabidopsis
Müller, D., Schmitz, G., & Theres, K. (2006) · The Plant Cell · doi:10.1105/tpc.105.038745 · Cited by 303 · cited 4×
“Genetic studies in Arabidopsis thaliana and other species have shown that AM initiation is regulated by several transcription factors, suchasLATERALSUPPRESSOR (LAS),REGULATOROF AXILLARY MERISTEMS (RAX), and REVOLUTA (REV) (Talbert et al., 1995; Greb et al., 2003; Müller et al., 2006).”
BackgroundInfluentialRaman, S., Greb, T., Peaucelle, A., Blein, T., Laufs, P., & Theres, K. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03483.x · Cited by 299
The Stem Cell Niche in Leaf Axils Is Established by Auxin and Cytokinin in Arabidopsis
Wang, Y., Wang, J., Shi, B., Yu, T., Qi, J., Meyerowitz, E. M., & Jiao, Y. (2014) · The Plant Cell · doi:10.1105/tpc.114.123083 · Cited by 207
Self-citationWang, Q., Kohlen, W., Rossmann, S., Vernoux, T., & Theres, K. (2014) · The Plant Cell · doi:10.1105/tpc.114.123059 · Cited by 172
Cited by
Cytokinin signaling in plant development
Kieber, J. J., & Schaller, G. E. (2018) · Development · doi:10.1242/dev.149344 · Cited by 758
Epigenetics and Plant Hormone Dynamics: A Functional and Methodological Perspective
Rudolf, J., Tomovicova, L., Panzarova, K., Fajkus, J., Hejatko, J., & Skalak, J. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae054 · Cited by 35
Metadata
- Authors
- Wang, J., Tian, C., Zhang, C., Shi, B., Cao, X., Zhang, T.-Q., Zhao, Z., Wang, J.-W., & Jiao, Y.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06
- Volume
- 29
- Issue
- 6
- Pages
- 1373-1387
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2620680560
- Cited by
- 226
- References
- 13
- FWCI
- 19.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation. https://app.cochat.ai/papers/10.1105/tpc.16.00579
- The paper
- Wang, J., Tian, C., Zhang, C., Shi, B., Cao, X., Zhang, T.-Q., Zhao, Z., Wang, J.-W., & Jiao, Y. (2017). Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation. The Plant Cell. https://doi.org/10.1105/tpc.16.00579
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
