The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Radiation damage in macromolecular crystallography: what is it and why should we care?
Open accessAbstract
Radiation damage inflicted during diffraction data collection in macromolecular crystallography has re-emerged in the last decade as a major experimental and computational challenge, as even for crystals held at 100 K it can result in severe data-quality degradation and the appearance in solved structures of artefacts which affect biological interpretations. Here, the observable symptoms and basic physical processes involved in radiation damage are described and the concept of absorbed dose as the basic metric against which to monitor the experimentally observed changes is outlined. Investigations into radiation damage in macromolecular crystallography are ongoing and the number of studies is rapidly increasing. The current literature on the subject is compiled as a resource for the interested researcher.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ward, J. F. (1988) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60611-x · Cited by 1,492
The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution
Schlichting, I., Berendzen, J., Chu, K., Stock, A. M., Maves, S. A., Benson, D. E., Sweet, R. M., Ringe, D., Petsko, G. A., & Sligar, S. G. (2000) · Science · doi:10.1126/science.287.5458.1615 · Cited by 1,331
The catalytic pathway of horseradish peroxidase at high resolution
Berglund, G. I., Carlsson, G. H., Smith, A. T., Szöke, H., Henriksen, A., & Hajdu, J. (2002) · Nature · doi:10.1038/417463a · Cited by 956
Yano, J., Kern, J., Irrgang, K.-D., Latimer, M. J., Bergmann, U., Glatzel, P., Pushkar, Y., Biesiadka, J., Loll, B., Sauer, K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505207102 · Cited by 589
An assessment of the resolution limitation due to radiation-damage in X-ray diffraction microscopy
Howells, M. R., Beetz, T., Chapman, H. N., Cui, C., Holton, J. M., Jacobsen, C. J., Kirz, J., Lima, E., Marchesini, S., Miao, H., et al. (2009) · Journal of Electron Spectroscopy and Related Phenomena · doi:10.1016/j.elspec.2008.10.008 · Cited by 524
Principles of Protein X-Ray Crystallography
(2007) · Springer eBooks · doi:10.1007/0-387-33746-6 · Cited by 519
Specific chemical and structural damage to proteins produced by synchrotron radiation
Weik, M., Ravelli, R. B. G., Kryger, G., McSweeney, S., Raves, M. L., Harel, M., Gros, P., Silman, I., Kroon, J., & Sussman, J. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.623 · Cited by 444
Crystal Structure of a Photolyase Bound to a CPD-Like DNA Lesion After in Situ Repair
Mees, A., Klar, T., Gnau, P., Hennecke, U., Eker, A. P. M., Carell, T., & Essen, L.-O. (2004) · Science · doi:10.1126/science.1101598 · Cited by 386
Experimental determination of the radiation dose limit for cryocooled protein crystals
Owen, R. L., Rudiño-Piñera, E., & Garman, E. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600973103 · Cited by 356
Self-citationStructural changes in a cryo-cooled protein crystal owing to radiation damage
Burmeister, W. P. (2000) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444999016261 · Cited by 324
Cited by
Metal–organic frameworks (MOFs) beyond crystallinity: amorphous MOFs, MOF liquids and MOF glasses
Fonseca, J., Gong, T., Jiao, L., & Jiang, H.-L. (2021) · Journal of Materials Chemistry A · doi:10.1039/d1ta01043c · Cited by 543
Serial Femtosecond Crystallography of G Protein–Coupled Receptors
Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., et al. (2013) · Science · doi:10.1126/science.1244142 · Cited by 455
Protein structure prediction has reached the single-structure frontier
Lane, T. J. (2023) · Nature Methods · doi:10.1038/s41592-022-01760-4 · Cited by 125
Femtosecond X-ray-induced explosion of C60 at extreme intensity
Murphy, B. F., Osipov, T., Jurek, Z., Fang, L., Son, S.-K., Mucke, M., Eland, J. H. D., Zhaunerchyk, V., Feifel, R., Avaldi, L., et al. (2014) · Nature Communications · doi:10.1038/ncomms5281 · Cited by 138
The domain swapping of human cystatin C induced by synchrotron radiation
Taube, M., Pietralik, Z., Szymanska, A., Szutkowski, K., Clemens, D., Grubb, A., & Kozak, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-44811-1 · Cited by 20
Metadata
- Authors
- Garman, E. F.
- Venue
- Acta Crystallographica Section D Biological Crystallography
- Published
- 2010-03-24
- Volume
- 66
- Issue
- 4
- Pages
- 339-351
- ISSN
- 0907-4449 (ISSN-L)
- OpenAlex
- W2106844014
- Cited by
- 366
- References
- 62
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Radiation damage in macromolecular crystallography: what is it and why should we care? https://app.cochat.ai/papers/10.1107/s0907444910008656
- The paper
- Garman, E. F. (2010). Radiation damage in macromolecular crystallography: what is it and why should we care? Acta Crystallographica Section D Biological Crystallography. https://doi.org/10.1107/s0907444910008656
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
