Closed-loop stimulation of hypoglossal nerve in a dog model of upper airway obstruction
Abstract
Electrical stimulation of upper airway (UAW) muscles has been under investigation as a treatment method for obstructive sleep apnea (OSA). Particular attention has been given to the electrical activation of the genioglossal muscle, either directly or via the stimulation of the hypoglossal nerve (HG), since the genioglossus is the main tongue protrusor muscle. Regardless of the stimulation site or method, an implantable electrical stimulation device for OSA patients will require a reliable method for detection of obstructive breaths to apply the stimulation when needed. In this paper, we test the hypothesis that the activity of the HG nerve can be used as a feedback signal for closed-loop stimulation of the HG nerve in an animal model of UAW obstruction where a force is applied on the submental region to physically narrow the airways. As an advantage, the method uses a single electrode for both recording and stimulation of the HG nerve. Simple linear filtering techniques were found to be adequate for producing the trigger signal for the electrical stimulation from the HG recordings. Esophageal pressure, which was used to estimate the size of the UAW passage, returned to the preloading values during closed-loop stimulation of the HG nerve. The data demonstrate the feasibility of the closed-loop stimulation of the HG nerve using its activity as the feedback signal.
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Sahin et al. demonstrated a closed-loop PNS neuromodulation device for treating obstructive sleep apnea.
“Similarly, Sahin et al. [116] demonstrated a closed-loop PNS neuromodulation device to treat obstructive sleep apnea.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [116]
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Implantable neurotechnologies: a review of integrated circuit neural amplifiers
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- Authors
- Sahin, M., Durand, D. H., & Haxhiu, M. A.
- Affiliations
- Case Western Reserve University (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2000-07
- Volume
- 47
- Issue
- 7
- Pages
- 919-925
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2104433625
- Cited by
- 22
- References
- 32
- Citations by year
- 2023: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21hl061775-02)
- National Heart, Lung, and Blood Institute (R01HL050527, HL61775, HL 50527)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- hypoglossal nerve stimulation, closed-loop stimulation, upper airway obstruction, obstructive sleep apnea, genioglossus muscle, esophageal pressure
- MeSH terms
- Airway Obstruction, Animals, Biomedical Engineering, Disease Models, Animal, Dogs, Electric Stimulation Therapy, Feedback, Hypoglossal Nerve, Pressure, Sleep Apnea, Obstructive
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