Optical fiber sensors for monitoring in critical care
Abstract
Monitoring of key physiological and pharmacological parameters is an important part of a closed loop control system in critical care. Optical fiber sensors provide a versatile platform technology that can be easily incorporated into existing in-dwelling catheters or face masks. With appropriate functional coatings they can be used to monitor a range of relevant parameters and two different examples are presented: (i) respiration monitoring; (ii) drug level monitoring. Respiration monitoring involves monitoring of temperature and humidity in inhaled and exhaled breath. The optical fiber sensor consists of a fiber Bragg grating to measure temperature and a tip coating whose refractive index changes with humidity. The sensor is demonstrated to be able to track breath to breath changes when incorporated into a mask. Drug level monitoring is demonstrated in vitro using a long period grating coated with molecularly imprinted polymer nanoparticles that are sensitive to fentanyl. The sensor has a limit of detection of 50ng/ml.
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A long-term grating coated with molecularly imprinted fentanyl-sensitive polymer nanoparticles demonstrated in vitro drug level monitoring with a detection limit of 50 ng/mL.
“In vitro, drug level monitoring has also been demonstrated using a long-term grating coated with molecularly imprinted fentanyl-sensitive polymer nanoparticles (detection limit 50 ng/mL) [265].”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [265]
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- Authors
- Morgan, S. P., Canfarotta, F., Piletska, E. V., Grillo, F., Korposh, S., Liu, L., Hernandez, F. U., Correia, R., Norris, A., Sinha, R., Hayes-Gill, B. R., & Piletsky, S. A.
- Affiliations
- University of Nottingham (GB)
- University of Leicester (GB)
- Nottingham University Hospitals NHS Trust (GB)
- ORCID
- Venue
- 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
- Publisher
- IEEE
- Published
- 2019-07
- Volume
- 2019
- Pages
- 1139-1143
- ISSN
- 2375-7477 (ISSN-L)
- OpenAlex
- W2979704247
- Cited by
- 13
- References
- 21
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 3
- FWCI
- 3.57
- Type
- conference paper
- Language
- en
- Open access
- closed
- Licence
- Locations
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Engineering and Physical Sciences Research Council (EP/N026985/1)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Fiber Optic Sensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- fiber optic sensors, intensive care monitoring, feedback control, fiber Bragg grating, long-period fiber grating, respiratory monitoring, face masks, therapeutic drug monitoring, fentanyl detection, functional coatings
- MeSH terms
- Critical Care, Fiber Optic Technology, Humans, Humidity, Refractometry, Optical Fibers
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