Fundus Disease Image Classification based on Improved Transformer
Abstract
In recent years, the progress of deep learning and fundus camera technology makes it possible to diagnose fundus diseases by computer. However, the fundus image dataset is relatively small, which makes the pure transformer model challenging to be applied to medical disease analysis. Therefore, this paper proposes a Transformer Eye (TransEye) fine-grained fundus disease image classification method based on the self-attention mechanism to assist diagnosis. TransEye combines the advantages of Convolution Neural Network (CNN) and Transformer model. It can not only effectively extract the underlying features, but also establish the remote dependence of the image. So, it can locate the most discriminative image area and complete end-to-end training. Evaluated the classification effect of our method on the preprocessed OIA dataset, the experimental results show the superiority of TransEye.
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Most works in medical image classification jointly adopt CNN and transformer but did not develop a transformer-based backbone without convolutions to capture multi-granularity information in medical images.
“Most works [30 -34] in medical image classi fi cation jointly adopt the CNN and transformer model but did not develop a transformer-based backbone without convolutions to capture multi-granularity information in medical images.”
From DilatedFormer: dilated granularity transformer network for placental maturity grading in ultrasound (2023) · cites this paper as [30]
Cites
Deep Residual Learning for Image Recognition
He, K., Zhang, X., Ren, S., & Sun, J. (2016) · 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2016.90 · Cited by 235,474 · see citing works
Vaswani, A., Shazeer, N., Parmar, N., Uszkoreit, J., Jones, L., Gomez, A. N., Kaiser, L., & Polosukhin, I. (2017) · arXiv · doi:10.48550/arxiv.1706.03762 · Cited by 120,404 · see citing works
ImageNet classification with deep convolutional neural networks
Krizhevsky, A., Sutskever, I., & Hinton, G. E. (2017) · Communications of the ACM · doi:10.1145/3065386 · Cited by 112,155 · see citing works
Hochreiter, S., & Schmidhuber, J. (1997) · Neural Computation · doi:10.1162/neco.1997.9.8.1735 · Cited by 102,318 · see citing works
Very Deep Convolutional Networks for Large-Scale Image Recognition
Simonyan, K., & Zisserman, A. (2014) · arXiv · doi:10.48550/arxiv.1409.1556 · Cited by 74,248 · see citing works
ImageNet Large Scale Visual Recognition Challenge
Russakovsky, O., Deng, J., Su, H., Krause, J., Satheesh, S., Ma, S., Huang, Z., Karpathy, A., Khosla, A., Bernstein, M., et al. (2015) · International Journal of Computer Vision · doi:10.1007/s11263-015-0816-y · Cited by 39,380 · see citing works
Rethinking the Inception Architecture for Computer Vision
Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., & Wojna, Z. (2016) · 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2016.308 · Cited by 32,138 · see citing works
Visualizing and understanding convolutional networks
Zeiler, M. D., & Fergus, R. (2014) · Lecture Notes in Computer Science · doi:10.1007/978-3-319-10590-1_53 · Cited by 15,839 · see citing works
Dimensionality Reduction by Learning an Invariant Mapping
Hadsell, R., Chopra, S., & LeCun, Y. (2006) · 2006 IEEE Computer Society Conference on Computer Vision and Pattern Recognition - Volume 2 (CVPR'06) · doi:10.1109/cvpr.2006.100 · Cited by 5,336 · see citing works
TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation
Chen, J., Lu, Y., Yu, Q., Luo, X., Adeli, E., Wang, Y., Lu, L., Yuille, A. L., & Zhou, Y. (2021) · arXiv · doi:10.48550/arxiv.2102.04306 · Cited by 4,206 · see citing works
Self-citationRidge-based vessel segmentation in color images of the retina
Staal, J., Abramoff, M. D., Niemeijer, M., Viergever, M. A., & van Ginneken, B. (2004) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2004.825627 · Cited by 4,202 · see citing works
A Discriminative Feature Learning Approach for Deep Face Recognition
Wen, Y., Zhang, K., Li, Z., & Qiao, Y. (2016) · Lecture Notes in Computer Science · doi:10.1007/978-3-319-46478-7_31 · Cited by 4,077 · see citing works
Rethinking Semantic Segmentation from a Sequence-to-Sequence Perspective with Transformers
Zheng, S., Lu, J., Zhao, H., Zhu, X., Luo, Z., Wang, Y., Fu, Y., Feng, J., Xiang, T., Torr, P. H. S., et al. (2021) · 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr46437.2021.00681 · Cited by 4,008 · see citing works
Transformers in Vision: A Survey
Khan, S., Naseer, M., Hayat, M., Zamir, S. W., Khan, F. S., & Shah, M. (2022) · ACM Computing Surveys · doi:10.1145/3505244 · Cited by 3,595 · see citing works
Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response
Hoover, A. D., Kouznetsova, V. L., & Goldbaum, M. H. (2000) · IEEE Transactions on Medical Imaging · doi:10.1109/42.845178 · Cited by 2,613 · see citing works
Bilinear CNN Models for Fine-Grained Visual Recognition
Lin, T., RoyChowdhury, A., & Maji, S. (2015) · IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.2015.170 · Cited by 2,207 · see citing works
Deformable DETR: Deformable Transformers for End-to-End Object Detection
Zhu, X., Su, W., Lu, L., Li, B., Wang, X., & Dai, J. (2020) · arXiv · doi:10.48550/arxiv.2010.04159 · Cited by 1,837 · see citing works
Medical Transformer: Gated Axial-Attention for Medical Image Segmentation
Valanarasu, J. M. J., Oza, P., Hacihaliloglu, I., & Patel, V. M. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-87193-2_4 · Cited by 1,566 · see citing works
Porwal, P., Pachade, S., Kamble, R. M., Kokare, M., Deshmukh, G., Sahasrabuddhe, V., & Mériaudeau, F. (2018) · Data · doi:10.3390/data3030025 · Cited by 932 · see citing works
Self-Attention Graph PoolingPreprint
Lee, J., Lee, I., & Kang, J. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1904.08082 · Cited by 869 · see citing works
TransFG: A Transformer Architecture for Fine-Grained Recognition
He, J., Chen, J.-N., Liu, S., Kortylewski, A., Yang, C., Bai, Y., & Wang, C. (2022) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v36i1.19967 · Cited by 551 · see citing works
Self-citationTransMed: Transformers Advance Multi-Modal Medical Image Classification
Dai, Y., Gao, Y., & Liu, F. (2021) · Diagnostics · doi:10.3390/diagnostics11081384 · Cited by 489 · see citing works
Dynamic Deep Networks for Retinal Vessel Segmentation
Khanal, A., & Estrada, R. G. (2020) · Frontiers in Computer Science · doi:10.3389/fcomp.2020.00035 · Cited by 58 · see citing works
Training data-efficient image transformers & distillation through attention
Hugo, T., Cord, M., Douze, M., Francisco, M., Alexandre, S., & Jeǵou, H. (2021) · HAL · Cited by 36 · see citing works
Azamoum, Y., Tcheremiskine, V. I., Clady, R. G. C. R., Ferré, A., Charmasson, L., Uteza, O. P., & Sentis, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-22487-3 · Cited by 34 · see citing works
Blood Vessel Extraction for retinal images using morphological operator and KCN clustering
Mehrotra, A., Tripathi, S., Singh, K. K., & Khandelwal, P. (2014) · IEEE International Advance Computing Conference · doi:10.1109/iadcc.2014.6779487 · Cited by 30 · see citing works
Relationship of Retinal Vascular Caliber with Optic Disc and Macular Structure
Lim, L. S., Saw, S., Cheung, N., Mitchell, P., & Wong, T. Y. (2009) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2009.04.006 · Cited by 26 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Transformers in medical imaging: A survey
Shamshad, F., Khan, S., Zamir, S. W., Khan, M. H., Hayat, M., Khan, F. S., & Fu, H. (2023) · Medical Image Analysis · doi:10.1016/j.media.2023.102802 · Cited by 1,412 · see citing works
Transformers in medical image analysis
He, K., Chen, G., Li, Z., Rekik, I., Yin, Z., Wen, J., Gao, Y., Wang, Q., Zhang, J., & Shen, D. G. (2022) · Intelligent Medicine · doi:10.1016/j.imed.2022.07.002 · Cited by 571 · see citing works
Gu, Z., Li, Y., Wang, Z., Kan, J., Shu, J., & Wang, Q. (2023) · Computational Intelligence and Neuroscience · doi:10.1155/2023/1305583 · Cited by 117 · see citing works
Ikram, A., & Imran, A. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.109656 · Cited by 83 · see citing works
A Survey on Attention Mechanisms for Medical Applications: are we Moving Toward Better Algorithms?
Gonçalves, T., Rio-Torto, I., Teixeira, L. F., & Cardoso, J. S. (2022) · IEEE Access · doi:10.1109/access.2022.3206449 · Cited by 81 · see citing works
Yang, Y., Cai, Z., Qiu, S., & Xu, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0299265 · Cited by 71 · see citing works
CoT-XNet: contextual transformer with Xception network for diabetic retinopathy grading
Zhao, S., Wu, Y., Tong, M., Yao, Y., Qian, W., & Qi, S. (2022) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ac9fa0 · Cited by 51 · see citing works
Karthika, S., & Durgadevi, M. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.105674 · Cited by 35 · see citing works
Sıvaz, O., & Aykut, M. (2024) · Neural Computing and Applications · doi:10.1007/s00521-024-09820-w · Cited by 32 · see citing works
Ma, L., Xu, Q., Hong, H., Shi, Y., Zhu, Y., & Wang, L. (2023) · Applied Intelligence · doi:10.1007/s10489-023-04949-y · Cited by 26 · see citing works
Chae, J., & Kim, J. (2023) · Applied Sciences · doi:10.3390/app13158671 · Cited by 21 · see citing works
Kılıç, Ş. (2025) · Ain Shams Engineering Journal · doi:10.1016/j.asej.2025.103594 · Cited by 16 · see citing works
Huang, Y., Chen, L.-T., Zhou, C., Yan, N., Qiao, L., Lan, S., & Wen, Y. (2023) · Knowledge-Based Systems · doi:10.1016/j.knosys.2023.110544 · Cited by 12 · see citing works
A survey on attention mechanisms for medical applications: are we moving towards better algorithms?Preprint
Gonçalves, T., Rio-Torto, I., Teixeira, L. F., & Cardoso, J. S. (2022) · Research Square · doi:10.21203/rs.3.rs-1594205/v1 · Cited by 11 · see citing works
Image-level multi-label retinal disease classification with a novel classification head
Sıvaz, O., & Aykut, M. (2025) · Computers & Electrical Engineering · doi:10.1016/j.compeleceng.2025.110410 · Cited by 5 · see citing works
Transformer for medical image analysis
Shamshad, F., Khan, S. A., Zamir, S. W., Khan, M. H., Hayat, M., Khan, F. S., & Fu, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-32-385124-4.00012-x · Cited by 3 · see citing works
DilatedFormer: dilated granularity transformer network for placental maturity grading in ultrasound
Wu, Y., Yang, Y., Zhu, L., Han, Z., Luo, H., Xue, X., & Wang, W. (2023) · Frontiers in Physics · doi:10.3389/fphy.2023.1239400 · Cited by 2 · see citing works
Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology
Yin, S., Wang, L., Wu, S., Jiang, J., Qiang, W., Wang, Y., Wang, S., Shao, Y., Chen, W., & Li, Z. (2025) · Advanced Intelligent Systems · doi:10.1002/aisy.202500055 · Cited by 4 · see citing works
Shuang, 赵. Z., Ge, 穆. M., Wenhua, 赵. Z., & Zhiqing, 马. M. (2023) · Laser & Optoelectronics Progress · doi:10.3788/lop222415 · Cited by 2 · see citing works
Integrating GANs, Contrastive Learning, and Transformers for Robust Medical Image Analysis
Heng, Y., Khan, F. G., Yinghua, M., Khan, A., Ali, F., Khan, N., & Kwak, D. (2025) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2025.3604845 · Cited by 1 · see citing works
Base on Megapixel Color Fundus Photos for Multi-label Disease Classification
Yang, H., Chen, J., Luan, R., Xu, M., Ma, L., & Zhou, X. (2022) · International Conference on Advanced Computational Intelligence (ICACI) · doi:10.1109/icaci55529.2022.9837676 · Cited by 1 · see citing works
Self-citationTransformer-based diagnosis of nerve root compromise in MR imaging of lumbar spine
Li, Y., Chen, J., Su, Z., Hai, J., Qiao, K., Qin, R., Lü, H., & Yan, B. (2022) · International Conference on Biomedical and Intelligent Systems (IC-BIS) · doi:10.1117/12.2660639 · Cited by 1 · see citing works
Self-citationBERTImages for Diabetic Retinopathy Classification
Benabdessalam, N., Mabrouk, S., & Ghorbel, F. (2023) · IEEE/ACS International Conference on Computer Systems and Applications (AICCSA) · doi:10.1109/aiccsa59173.2023.10479275 · Cited by 1 · see citing works
Evaluation of Regularization Techniques for Transformers-Based Models
Oliveira, H. S., Ribeiro, P., & Oliveira, H. P. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-36616-1_25
Diabetic Retinopathy Prediction Using DenseNet 201 with Swish as Activation Function
Yang, C.-C., Mahrukh, M., Delanyo, K., Bensah, K., & Khokhar, S.-U.-D. (2024) · International Conference on Robotics and Computer Vision (ICRCV) · doi:10.1109/icrcv62709.2024.10758570
Attention-Enhanced Deep Learning for Accurate Musculoskeletal X-Ray ClassificationPreprint
Alammar, Z., Alzubaidi, L., Zhang, J., Li, Y., & Gu, Y. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5143442
An Automated Diagnosis of Diabetic Retinopathy Grading Using DenseNet169
Yang, C.-C., Li, N., Bensah, K. D. K., Khokhar, S.-U.-D., & Mahrukh, M. (2025) · International Conference on Computer Research and Development · doi:10.1109/iccrd64588.2025.10963051
Zarrin, I., Ahmed, M., & Masood, S. (2025) · International Conference on Innovative Mechanisms for Industry Applications · doi:10.1109/icimia67127.2025.11200710
Xue, Z., Pi, P., Liu, Z., Zeng, Z., & Sun, Z. (2026) · PLoS ONE · doi:10.1371/journal.pone.0340108
A Deep Hybrid Approach for Automated Detection and Grading of Diabetic Retinopathy
Ikram, A., Abbasi, S. J., Daud, A., & Imran, A. (2025) · International Conference on Emerging Technologies · doi:10.1109/icet66147.2025.11321436
Bali, A., Singh, K., & Mansotra, V. (2026) · International Journal of Imaging Systems and Technology · doi:10.1002/ima.70308
- Authors
- Yang, H., Chen, J., & Xu, M.
- Affiliations
- Hubei Normal University (CN)
- Venue
- 2021 International Conference on Neuromorphic Computing (ICNC)
- Publisher
- IEEE
- Published
- 2021-10-15
- Pages
- 207-214
- OpenAlex
- W3216097109
- Cited by
- 31
- References
- 28
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 6
- FWCI
- 6.28
- Type
- conference paper
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Conference on Neuromorphic Computing (ICNC) (publishedVersion)
- Funders
- Natural Science Foundation of China (61976085)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Visual Health Research
- Keywords
- fundus images, transformer models, self-attention, CNN-Transformer hybrid, small medical image datasets, eye disease diagnosis
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