Disposable Smart Lab on a Chip for Point-of-Care Clinical Diagnostics
Abstract
This paper presents the development of a disposable plastic biochip incorporating smart passive microfluidics with embedded on-chip power sources and integrated biosensor array for applications in clinical diagnostics and point-of-care testing. The fully integrated disposable biochip is capable of precise volume control with smart microfluidic manipulation without costly on-chip microfluidic components. The biochip has a unique power source using on-chip pressurized air reservoirs, for microfluidic manipulation, avoiding the need for complex microfluidic pumps. In addition, the disposable plastic biochip has successfully been tested for the measurements of partial oxygen concentration, glucose, and lactate level in human blood using an integrated biosensor array. This paper presents details of the smart passive microfluidic system, the on-chip power source, and the biosensor array together with a detailed discussion of the plastic micromachining techniques used for chip fabrication. A handheld analyzer capable of multiparameter detection of clinically relevant parameters has also been developed to detect the signals from the cartridge type disposable biochip. The handheld analyzer developed in this work is currently the smallest analyzer capable of multiparameter detection for point-of-care testing.
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Ahn et al. developed a low-cost disposable plastic lab-on-a-chip device for biochemical detection of parameters such as blood gas concentration and glucose.
“Similarly, Ahn et al. [35] developed a low-cost disposable plastic lab-on-a-chip device for biochemical detection of parameters such as blood gas concentration and glucose.”
From A review of wearable sensors and systems with application in rehabilitation (2012) · cites this paper as [35]
The Ahn et al. biochip contains an integrated biosensor array for detecting multiple parameters and uses a passive microfluidic manipulation system instead of active microfluidic pumps.
“The biochip contains an integrated biosensor array for detecting multiple parameters and uses a passive microfluidic manipulation system instead of active microfluidic pumps.”
From A review of wearable sensors and systems with application in rehabilitation (2012) · cites this paper as [35]
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A review of wearable sensors and systems with application in rehabilitation
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- Authors
- Ahn, C. H., Choi, J.-W., Beaucage, G., Nevin, J., Lee, J.-B., Puntambekar, A., & Lee, R. J. Y.
- Affiliations
- University of Cincinnati (US)
- Louisiana State University (US)
- The University of Texas at Dallas (US)
- The Ohio State University (US)
- Venue
- Proceedings of the IEEE
- Published
- 2004-01
- Volume
- 92
- Issue
- 1
- Pages
- 154-173
- ISSN
- 0018-9219 (ISSN-L)
- OpenAlex
- W2146795298
- Cited by
- 504
- References
- 68
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 19 · 2017: 22 · 2016: 28 · 2015: 37 · 2014: 29 · 2013: 37 · 2012: 30
- FWCI
- 27.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Proceedings of the IEEE (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Keywords
- point-of-care testing, passive microfluidics, glucose measurement, lactate measurement
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