Flexible MEMS Neural Interface for Long-Term Minimally Invasive Deep-Brain Recording Within CSF Environments
Abstract
This paper presents a flexible deep-brain neural interface fabricated using MEMS technology, consisting of a deformable microelectrode array mechanically coupled to a shape-memory silk fibroin scaffold. The device is delivered to the lateral ventricle via standard neurosurgical catheters and, upon exposure to cerebrospinal fluid (CSF), self-unfolds to conformally appose periventricular surfaces and support stable, high-fidelity electrophysiological recordings. In a chronic Parkinson disease (PD) sheep model, implantation targeting the head of the caudate nucleus enabled minimally invasive intraventricular recordings over a four-week period in freely moving animals. Longitudinal analysis of pathological oscillatory activity, particularly in the beta band, demonstrates that chronic intraventricular electrophysiology provides a viable route for tracking dynamic neural biomarkers during Parkinsonian disease progression.
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Cites
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.
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Underwater and wet adhesion strategies for hydrogels in biomedical applications
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Liang, J., Lai, S., Wang, X., Chen, Z., Wei, X., Sun, L., Tao, T. H., & Zhou, Z. (2025) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems61431.2025.10918019 · Cited by 3 · see citing works
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- Authors
- Liang, J., Li, X., Wang, X., Tao, T. H., & Zhou, Z.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of Chinese Academy of Sciences (CN)
- Neuroxess Co., Ltd.,Shanghai,China
- Venue
- 2026 IEEE 39th International Conference on Micro Electro Mechanical Systems (MEMS)
- Publisher
- IEEE
- Published
- 2026-01-25
- Pages
- 223-226
- ISSN
- 1084-6999 (ISSN-L)
- OpenAlex
- W7135043727
- Cited by
- 0
- References
- 6
- FWCI
- 0.00
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced MEMS and NEMS Technologies
- Keywords
- flexible neural interfaces, cerebrospinal fluid, deep brain recording, Parkinson's disease, beta oscillations, caudate nucleus, chronic electrophysiology, sheep model, neural markers
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