CoChat
Sign Up
Cited by 15Neuroscience and Neural EngineeringCardiac pacing and defibrillation studiesCardiac electrophysiology and arrhythmias

High-frequency electrical stimulation of cardiac cells and application to artifact reduction.

Dura, B., Chen, M. Q., Inan, O. T., Kovacs, G. T. A., Giovangrandi, L.·2012·IEEE Transactions on Biomedical Engineering
DOI 10.1109/tbme.2012.2188136
Open this paper in CoChat — free account

Abstract

A novel modality for the electrical stimulation of cardiac cells is described. The technique is based on HF stimulation-burst of HF (1-25 kHz) biphasic square waves-to depolarize the cells and trigger action potentials (APs). HF stimulation was demonstrated in HL-1 cardiomyocyte cultures using microelectrode arrays, and the underlying mechanisms were investigated using single-cell model simulations. Current thresholds for HF stimulation increased at higher frequencies or shorter burst durations, and were typically higher than thresholds for single biphasic pulses. Nonetheless, owing to the decreasing impedance of metal electrodes with increasing frequencies, HF bursts resulted in reduced electrode voltages (up to four fold). Such lowered potentials might be beneficial in reducing the probability of irreversible electrochemical reactions and tissue damage, especially for long-term stimulation. More significantly, stimulation at frequencies higher than the upper limit of the AP power spectrum allows effective artifact reduction by low-pass filtering. Shaping of the burst envelope provides further reduction of the remaining artifact. This ability to decouple extracellular stimulation and recording in the frequency domain allowed detection of APs during stimulation-something previously not achievable to the best of our knowledge.

Integrity signals

Registry

Crossref · 10.1109/tbme.2012.2188136

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In Dura et al. (2012) and Chu et al. (2013), high-frequency short-duration pulses or other specific patterns are adopted for stimulation.

    “In Dura et al. (2012) and Chu et al. (2013), high-frequency short-duration pulses or other specific patterns are adopted for stimulation.”

    From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Dura et al., 2012

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Dura, B., Chen, M. Q., Inan, O. T., Kovacs, G. T. A., & Giovangrandi, L.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Stanford University (US)
ORCID
Venue
IEEE Transactions on Biomedical Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
2012-05
Volume
59
Issue
5
Pages
1381-1390
ISSN
  • 0018-9294 (ISSN-L)
  • 1558-2531
DOI
10.1109/tbme.2012.2188136
OpenAlex
W1987353517
Cited by
15
References
38
Citations by year
2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2014: 2 · 2012: 1
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Licence
ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations
  • IEEE Transactions on Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
high-frequency electrical stimulation, cardiomyocytes, HL-1 cardiomyocytes, microelectrode arrays, stimulation threshold, electrode impedance, artifact reduction, low-pass filtering, extracellular recording
MeSH terms
Animals, Cell Line, Computer Simulation, Electric Stimulation, Microelectrodes, Radio Waves, Artifacts, Myocytes, Cardiac, Mice, Single-Cell Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review