Cited by 95Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignNeural dynamics and brain function

Stimulus-artifact elimination in a multi-electrode system.

Brown, Edgar A., Ross, James D., Blum, Richard A., Nam, Yoonkey, Wheeler, Bruce C., DeWeerth, Stephen P.·2008·IEEE Transactions on Biomedical Circuits and Systems

Abstract

To fully exploit the recording capabilities provided by current and future generations of multi-electrode arrays, some means to eliminate the residual charge and subsequent artifacts generated by stimulation protocols is required. Custom electronics can be used to achieve such goals, and by making them scalable, a large number of electrodes can be accessed in an experiment. In this work, we present a system built around a custom 16-channel IC that can stimulate and record, within 3 ms of the stimulus, on the stimulating channel, and within 500 mus on adjacent channels. This effectiveness is achieved by directly discharging the electrode through a novel feedback scheme, and by shaping such feedback to optimize electrode behavior. We characterize the different features of the system that makes such performance possible and present biological data that show the system in operation. To enable this characterization, we present a framework for measuring, classifying, and understanding the multiple sources of stimulus artifacts. This framework facilitates comparisons between artifact elimination methodologies and enables future artifact studies.

Integrity signals

Registry

Crossref · 10.1109/tbcas.2008.918285

Cites

36 of 36 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Rdischarge is a variable resistance and the impedance is very large under normal conditions.

    “As shown in Figure 4B, Rdischarge is a variable resistance and the impedance is very large under normal conditions.”

    From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Brown et al., 2008

  • When a large artifact is detected, Rdischarge can be changed to a low-impedance value, reducing the RC time constant and making the electrode voltage quickly return to the reference voltage.

    “When a large artifact is detected, Rdischarge can be changed to a value with low impedance, then the RC time constant of the path is reduced and thus it makes the electrode voltage quickly return to the reference voltage.”

    From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Brown et al., 2008

  • This method reduces the recovery time from 10 ms to approximately 200 μs, but the problem of artifact recording has not been solved.

    “This method reduces the recovery time from 10 ms to approximately 200 μs, but the problem of artifact recording has not been solved.”

    From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Brown et al., 2008

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Authors
Brown, E. A., Ross, J. D., Blum, R. A., Nam, Y., Wheeler, B. C., & DeWeerth, S. P.
Affiliations
  • Georgia Institute of Technology (US)
  • Korea Advanced Institute of Science and Technology (KR)
  • University of Illinois Urbana-Champaign (US)
Venue
IEEE Transactions on Biomedical Circuits and Systems
Published
2008-03
Volume
2
Issue
1
Pages
10-21
ISSN
  • 1932-4545 (ISSN-L)
  • 1940-9990
OpenAlex
W2104093558
Cited by
95
References
37
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 5
FWCI
3.17
Type
journal article
Language
en
Open access
closed
Locations
  • IEEE Transactions on Biomedical Circuits and Systems (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Universidad Simón Bolívar
  • Wallace H. Coulter Department of Biomedical Engineering
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
stimulus artifact, microelectrode arrays, electrode stimulation, artifact removal, custom integrated circuits, residual charge, artifact classification, neural recording

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