Double-high-pass-filter-based electrical-recording front-ends and fluorescence-recording front-ends for monitoring multimodal neural activity.
Abstract
This brief presents a multimodal neural activity monitoring system consisting of a double-high-pass-filter-based electrical-recording front-end and a fluorescence-recording frontend. The proposed electrical-recording circuit based on double high-pass filters is implemented by placing a narrow-band buffer in the feedback path of the low-noise and programmable-gain amplifiers so that low-frequency artifacts can be sufficiently suppressed during the electrical and fluorescence recording. The implemented system successfully measures the electrical signals and calcium ions in vivo for studying heterogeneous cell populations. For electrical recording, the front-end consumes the power of 2 μW/channel and achieves the input-referred noise of 2.9 μVrms. The high-pass cutoff frequency can be programmed from sub-1 Hz to about 300 Hz using the function of double high-pass filtering. For fluorescence recording, the front-end consumes the power of 10.8 μW/block and occupies the area of 0.18 mm2/block.
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The artifact is typically hundreds of millivolts in amplitude, and 10 to 100 times higher than the amplitude of the recorded neural signals.
“The artifact is typically hundreds of millivolts in amplitude, and 10 to 100 times higher than the amplitude of the recorded neural signals (Dabbaghian et al., 2019; Lee and Je, 2020).”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Lee and Je, 2020
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Advances in Neural Recording and Stimulation Integrated Circuits
Li, J., Liu, X., Mao, W., Chen, T., & Yu, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.663204 · Cited by 21 · see citing works
Lee, T., Kim, M. K., Lee, H. J., & Je, M. (2022) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2022.3146324 · Cited by 13 · see citing works
A 1.01 NEF Low-Noise Amplifier Using Complementary Parametric Amplification
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Lee, T., & Je, M. (2020) · IEEE Transactions on Circuits & Systems II Express Briefs · doi:10.1109/tcsii.2020.3046451 · Cited by 7 · see citing works
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Lee, T., Kim, M. K., Lee, H. J., & Je, M. (2021) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas51556.2021.9401740 · Cited by 3 · see citing works
Lee, T., Choi, W., Kim, J., & Je, M. (2020) · IEEE International Midwest Symposium on Circuits and Systems (MWSCAS) · doi:10.1109/mwscas48704.2020.9184529 · Cited by 3 · see citing works
Lee, T., & Je, M. (2021) · IEEE International Midwest Symposium on Circuits and Systems (MWSCAS) · doi:10.1109/mwscas47672.2021.9531885 · Cited by 2 · see citing works
- Authors
- Lee, T., & Je, M.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- ORCID
- Venue
- IEEE Transactions on Circuits and Systems II: Express Briefs
- Published
- 2020-05
- Volume
- 67
- Issue
- 5
- Pages
- 876-880
- ISSN
- 1549-7747 (ISSN-L)
- 1558-3791
- OpenAlex
- W3010802056
- Cited by
- 8
- References
- 9
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 4 · 2020: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- IEEE Transactions on Circuits & Systems II Express Briefs (publishedVersion)
- Funders
- Brain Research Program (2017M3C7A1028859)
- Convergence Technology Development Program for Bionic Arm through the National Research Foundation of Korea
- Ministry of Science & ICT (2017M3C1B2085296)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Keywords
- low-power analog circuits, calcium imaging, programmable gain amplifier, input-referred noise, heterogeneous cell populations
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