An Integrated System for Multichannel Neuronal Recording With Spike/LFP Separation, Integrated A/D Conversion and Threshold Detection
Abstract
A mixed-signal front-end processor for multichannel neuronal recording is described. It receives 12 differential-input channels of implanted recording electrodes. A programmable cutoff High Pass Filter (HPF) blocks dc and low-frequency input drift at about 1 Hz. The signals are band-split at about 200 Hz to low-frequency Local Field Potential (LFP) and high-frequency spike data (SPK), which is band limited by a programmable-cutoff LPF, in a range of 8-13 kHz. Amplifier offsets are compensated by 5-bit calibration digital-to-analog converters (DACs). The SPK and LFP channels provide variable amplification rates of up to 5000 and 500, respectively. The analog signals are converted into 10-bit digital form, and streamed out over a serial digital bus at up to 8 Mbps. A threshold filter suppresses inactive portions of the signal and emits only spike segments of programmable length. A prototype has been fabricated on a 0.35-microm CMOS process and tested successfully, demonstrating a 3-microV noise level. Special interface system incorporating an embedded CPU core in a programmable logic device accompanied by real-time software has been developed to allow connectivity to a computer host.
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Neural amplifier ICs have been created that capture both action potentials and local field potentials, with separate filtering, amplification and output for each signal type.
“CNS amplifiers have also been developed that can acquire both types of signals, separately filtering, amplifying and outputting each signal type [46, 86, 100].”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [100]
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- Authors
- Perelman, Y., & Ginosar, R.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- ORCID
- Perelman, Yevgeny
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2007-01
- Volume
- 54
- Issue
- 1
- Pages
- 130-137
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2165280873
- Cited by
- 116
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 7
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Technion-Israel Institute of Technology
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Keywords
- spike detection, local field potentials, high-pass filter, band splitting, threshold detection, implanted electrodes, CMOS integrated circuit, real-time data acquisition
- MeSH terms
- Action Potentials, Amplifiers, Electronic, Analog-Digital Conversion, Animals, Cerebral Cortex, Differential Threshold, Electroencephalography, Equipment Design, Neurons, Signal Processing, Computer-Assisted, Systems Integration, Equipment Failure Analysis, Rats
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