The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
An Automatic Learning-Based Framework for Robust Nucleus Segmentation
Abstract
Computer-aided image analysis of histopathology specimens could potentially provide support for early detection and improved characterization of diseases such as brain tumor, pancreatic neuroendocrine tumor (NET), and breast cancer. Automated nucleus segmentation is a prerequisite for various quantitative analyses including automatic morphological feature computation. However, it remains to be a challenging problem due to the complex nature of histopathology images. In this paper, we propose a learning-based framework for robust and automatic nucleus segmentation with shape preservation. Given a nucleus image, it begins with a deep convolutional neural network (CNN) model to generate a probability map, on which an iterative region merging approach is performed for shape initializations. Next, a novel segmentation algorithm is exploited to separate individual nuclei combining a robust selection-based sparse shape model and a local repulsive deformable model. One of the significant benefits of the proposed framework is that it is applicable to different staining histopathology images. Due to the feature learning characteristic of the deep CNN and the high level shape prior modeling, the proposed method is general enough to perform well across multiple scenarios. We have tested the proposed algorithm on three large-scale pathology image datasets using a range of different tissue and stain preparations, and the comparative experiments with recent state of the arts demonstrate the superior performance of the proposed approach.
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ImageNet classification with deep convolutional neural networks
Krizhevsky, A., Sutskever, I., & Hinton, G. E. (2017) · Communications of the ACM · doi:10.1145/3065386 · Cited by 112,155
LeCun, Y., Bengio, Y., & Hinton, G. (2015) · Nature · doi:10.1038/nature14539 · Cited by 84,126
A fast learning algorithm for deep belief nets
Hinton, G. E., Osindero, S., & Teh, Y.-W. (2006) · Neural Computation · doi:10.1162/neco.2006.18.7.1527 · Cited by 16,336
Fast approximate energy minimization via graph cuts
Boykov, Y., Veksler, O., & Zabih, R. (2001) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/34.969114 · Cited by 6,988
Improving neural networks by preventing co-adaptation of feature detectors
Hinton, G. E., Srivastava, N., Krizhevsky, A., Sutskever, I., & Salakhutdinov, R. R. (2012) · arXiv · doi:10.48550/arxiv.1207.0580 · Cited by 6,382
A unified architecture for natural language processing: deep neural networks with multitask learning
Collobert, R., & Weston, J. (2008) · Proceedings of the 25th international conference on Machine learning - ICML '08 · doi:10.1145/1390156.1390177 · Cited by 5,058
Snakes, shapes, and gradient vector flow
Xu, C., & Prince, J. L. (1998) · IEEE Transactions on Image Processing · doi:10.1109/83.661186 · Cited by 4,001
Locality-constrained Linear Coding for image classification
Wang, J., Yang, J., Yu, K., Lv, F., Huang, T., & Gong, Y. (2010) · 2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition · doi:10.1109/cvpr.2010.5540018 · Cited by 3,100
Learning Hierarchical Features for Scene Labeling
Farabet, C., Couprie, C., Najman, L., & LeCun, Y. (2013) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2012.231 · Cited by 2,620
Hypercolumns for object segmentation and fine-grained localization
Hariharan, B., Arbelaez, P., Girshick, R., & Malik, J. (2015) · 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2015.7298642 · Cited by 1,511
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A survey on deep learning in medical image analysis
Litjens, G., Kooi, T., Bejnordi, B. E., Setio, A. A. A., Ciompi, F., Ghafoorian, M., van der Laak, J. A. W. M., van Ginneken, B., & Sánchez, C. I. (2017) · Medical Image Analysis · doi:10.1016/j.media.2017.07.005 · Cited by 15,332
Coudray, N., Ocampo, P. S., Sakellaropoulos, T., Narula, N., Snuderl, M., Fenyö, D., Moreira, A. L., Razavian, N., & Tsirigos, A. (2018) · Nature Medicine · doi:10.1038/s41591-018-0177-5 · Cited by 2,930
Digital pathology and artificial intelligence
Niazi, M. K. K., Parwani, A. V., & Gurcan, M. N. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30154-8 · Cited by 1,232
Nuclei Segmentation with Recurrent Residual Convolutional Neural Networks based U-Net (R2U-Net)
Alom, M. Z., Yakopcic, C., Taha, T. M., & Asari, V. K. (2018) · NAECON 2018 - IEEE National Aerospace and Electronics Conference · doi:10.1109/naecon.2018.8556686 · Cited by 1,020
Convolutional neural networks in medical image understanding: a survey
Sarvamangala, D. R., & Kulkarni, R. V. (2022) · Evolutionary Intelligence · doi:10.1007/s12065-020-00540-3 · Cited by 917
Metadata
- Authors
- Xing, F., Xie, Y., & Yang, L.
- Venue
- IEEE Transactions on Medical Imaging
- Published
- 2016-02
- Volume
- 35
- Issue
- 2
- Pages
- 550-566
- ISSN
- 0278-0062 (ISSN-L)
- 1558-254X
- OpenAlex
- W2280351290
- Cited by
- 351
- References
- 13
- FWCI
- 22.84
- Type
- journal article
- Language
- en
- Open access
- closed
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