Minoxidil 2% lotion for eyebrow enhancement: A randomized, double‐blind, placebo‐controlled, spilt‐face comparative study
Abstract
Topical minoxidil has been successfully used to treat androgenetic alopecia. It can also be applied to enhance eyebrows. However, there is no study comparing minoxidil lotion with placebo for eyebrow enhancement. In this trial, we determined the efficacy and safety of minoxidil 2% lotion for eyebrow enhancement compared with placebo. Forty patients were randomized for minoxidil on the eyebrow on one side of the face and placebo on the other. Efficacy was evaluated by global photographic assessment, eyebrow diameter, eyebrow count and subject's satisfaction. Side‐effects were also evaluated. Thirty‐nine patients (97.5%) completed the study. After 16 weeks, the minoxidil group achieved significantly better results in all measured outcomes compared to the placebo group. Side‐effects were minor and did not preclude patients from continuing the study. Our study suggests that minoxidil 2% lotion is a safe and effective treatment for eyebrow hypotrichosis.
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Topical minoxidil 2% solution effectiveness for eyebrow hypotrichosis was demonstrated in a first randomized trial by Lee et al. compared to placebo.
“Topical minoxidil 2% solution effectiveness for eyebrow hypotrichosis was evaluated in a first randomized trial by Lee et al. and demonstrated a significant and safe response when compared to placebo [23].”
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- Authors
- Lee, S., Tanglertsampan, C., Tanchotikul, M., & Worapunpong, N.
- Affiliations
- Mae Fah Luang University Hospital (TH)
- Corresponding author
- Tanglertsampan, Chuchai
- Venue
- The Journal of Dermatology
- Publisher
- Wiley
- Published
- 2013-11-08
- Volume
- 41
- Issue
- 2
- Pages
- 149-152
- ISSN
- 0385-2407 (ISSN-L)
- 1346-8138
- OpenAlex
- W1973792795
- Cited by
- 19
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- minoxidil, androgenetic alopecia, treatment efficacy, treatment safety, adverse effects
- MeSH terms
- Adult, Double-Blind Method, Eyebrows, Female, Humans, Hypotrichosis, Male, Minoxidil, Vasodilator Agents, Skin Cream
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