Oscillospira and related bacteria – From metagenomic species to metabolic features
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Summary: Oscillospira is an under‐studied anaerobic bacterial genus from Clostridial cluster IV that has resisted cultivation for over a century since the first time it was observed. In recent years its 16S rRNA gene was identified in several human gut microbiota studies where it was often associated with interesting traits, especially leanness. However, very little is known about its metabolism or physiology. Here we used nearly complete genomes derived from shot‐gun metagenomic data from the human gut to analyze Oscillospira and related bacteria. We used sequence similarity, gene neighbourhood information and manual metabolic pathway curation to decipher key metabolic features of this intriguing bacterial genus. We infer that Oscillospira species are butyrate producers, and at least some of them have the ability to utilize glucuronate, a common animal‐derived sugar that is both produced by the human host and consumed by that host in diets rich in animal products. These findings could help explain diet‐related inter‐individual variation in faecal Oscillospira levels as well as the observation that the presence of this genus is reduced in diseases that involve inflammation.
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The family Oscillospiraceae produces butyrate and is negatively associated with inflammatory diseases.
“the family Oscillospiraceae, which produces butyrate (Gophna, Konikoff & Nielsen, 2017), is negatively associated with inflammatory diseases (Walters, Xu & Knight, 2014)”
From The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy (2023) · cites this paper as Gophna, Konikoff & Nielsen, 2017
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“…and its end products include volatile fatty acids ( Morotomi, Nagai & Watanabe, 2012 ); the family Oscillospiraceae , which produces butyrate ( Gophna, Konikoff & Nielsen, 2017 ), is negatively associated with inflammatory diseases ( Walters, Xu & Knight, 2014 ); and the family…”
- Authors
- Gophna, U., Konikoff, T., & Nielsen, H. B.
- Affiliations
- Tel Aviv University (IL)
- Clinical Microbiomics (Denmark) (DK)
- Corresponding author
- Gophna, Uri
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2017-02-03
- Volume
- 19
- Issue
- 3
- Pages
- 835-841
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2566680380
- Cited by
- 409
- References
- 12
- Citations by year
- 2026: 36 · 2025: 46 · 2024: 48 · 2023: 68 · 2022: 48 · 2021: 56 · 2020: 51 · 2019: 30 · 2018: 16 · 2017: 9
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Environmental Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- Oscillospira, anaerobic bacteria, human gut microbiome, metagenome-assembled genomes, bacterial metabolism, butyrate production, 16S rRNA gene, inflammation
- MeSH terms
- Eubacteriales, Gastrointestinal Microbiome, Animals, Butyrates, Clostridium, Feces, Humans, RNA, Ribosomal, 16S, Genome, Bacterial, Metabolic Networks and Pathways, Metagenomics
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