The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Extending Life: Scientific Prospects and Political Obstacles
Abstract
I n the last two decades, biogerontologists have found that the pace of aging can be decelerated in mammals by dietary or genetic means. Though still largely unappreciated by the lay and scientific public alike, these discoveries belie the common assumption that human aging probably cannot be slowed and prompt the question of whether we can use our growing knowledge about aging to produce 90‐year‐old adults who are as healthy and active as today's 50‐year‐olds. This article explores three related issues: first, why discussions of antiaging medicines are no longer silly; next, why the development of antiaging strategies is making so little headway; and last, whether further work in this area would be worthwhile. By “aging” I mean a process that converts healthy young adults into less healthy older ones with an increasing risk of illness and death. This definition, which seems fairly innocuous, is careful enough to be controversial, because there are many interesting areas of investigation—studies of childhood development; specific late‐life diseases; death or proliferative ennui of cells in culture; leaf abscission; and time‐dependent changes in the chemical composition of wines, cheeses, and bones—that are sometimes proposed in various combinations as worthy of gerontological attention and governmental funding.
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Interventions that delay ageing would greatly benefit health.
“Because incidences of most diseases rise rapidly with age6, interventions that delay ageing would greatly benefit health7–8.”
From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [7]
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The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712
In Search of Methuselah: Estimating the Upper Limits to Human Longevity
Olshansky, S. J., Carnes, B. A., & Cassel, C. (1990) · Science · doi:10.1126/science.2237414 · Cited by 645
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Research works printed but not linked: 26
- 10.1111/j.1469-7998.1993.tb02665.x · DOI
- 10.1093/geronj/46.2.B47 · DOI
- 10.1038/384033a0 · DOI
- Carey J.R., 2000, Longevity Records: Life Spans of Mammals, Birds, Amphibians, Reptiles, and Fish
- 10.1210/endo.141.7.7586 · DOI · Paper page
- 10.1136/jech.54.2.97 · DOI
- 10.1073/pnas.111158898 · DOI · Paper page
- Holliday R., 1999, Understanding Ageing
- Krzisnik C., 1999, The “Little People” of the Island of Krk—Revisited: Etiology of Hypopituitarism Revealed, Journal of Endocrine Genetics, 1, 9
- 10.1093/gerona/51A.6.B403 · DOI
- 10.1093/geronj/40.6.671 · DOI
- Masoro E.J., 1995, Aging: Current Concepts, 3
- McCarter R., 1985, Does Food Restriction Retard Aging by Reducing the Metabolic Rate?, American Journal of Physiology, 248, E488
- 10.1093/jn/10.1.63 · DOI · Paper page
- 10.1111/j.1532-5415.1997.tb03781.x · DOI
- 10.1093/gerona/54.7.B297 · DOI
- 10.1093/gerona/55.9.B455 · DOI
- Orentreich N., 1993, Low Methionine Ingestion by Rats Extends Life Span, Journal of Nutrition, 123, 269
- 10.1038/366404a0 · DOI
- 10.1096/fasebj.8.15.8001743 · DOI · Paper page
- 10.1056/NEJM199007053230101 · DOI
- Samaras T.T., 1992, Impact of Height and Weight on Life Span, Bulletin of the World Health Organization, 70, 259
- 10.1056/NEJM199710023371407 · DOI
- 10.1093/geronj/43.2.B40 · DOI · Paper page
- 10.1111/j.1558-5646.1957.tb02911.x · DOI · Paper page
- 10.1093/geronj/40.6.657 · DOI
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Self-citationReport of the Lancet Commission on the Value of Death: Bringing death back into life
Sallnow, L., Smith, R., Ahmedzai, S. H., Bhadelia, A., Chamberlain, C., Cong, Y., Doble, B., Dullie, L., Durie, R., Finkelstein, E. A., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02314-x · Cited by 807
Strategies for targeting senescent cells in human disease
Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging · doi:10.1038/s43587-021-00121-8 · Cited by 501
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00414.x · Cited by 349
Self-citationDiscovery, development, and future application of senolytics: theories and predictions
Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T., & Kirkland, J. L. (2020) · The FEBS Journal · doi:10.1111/febs.15264 · Cited by 160
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.03.019 · Cited by 114
Science fact and the SENS agenda: What can we reasonably expect from ageing research?
Warner, H., Anderson, J., Austad, S., Bergamini, E., Bredesen, D., Butler, R., Carnes, B. A., Clark, B. F. C., Cristofalo, V., Faulkner, J., et al. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400555 · Cited by 74
Self-citationElsallabi, O., Patruno, A., Pesce, M., Cataldi, A., Carradori, S., & Gallorini, M. (2022) · Molecules · doi:10.3390/molecules27030738 · Cited by 67
Inconvenient Truths About Human Longevity
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Metadata
- Authors
- Miller, R. A.
- Venue
- The Milbank Quarterly
- Publisher
- Wiley
- Published
- 2002-03
- Volume
- 80
- Issue
- 1
- Pages
- 155-174
- ISSN
- 0887-378X
- 1468-0009
- Cited by
- 119
- References
- 2
- Language
- en
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