The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Towards an integrated model of bacterial conjugation
Open accessAbstract
Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It constitutes a key element in the dissemination of antibiotic resistance and virulence genes to human pathogenic bacteria. DNA transfer is mediated by a membrane-associated macromolecular machinery called Type IV secretion system (T4SS). T4SSs are involved not only in bacterial conjugation but also in the transport of virulence factors by pathogenic bacteria. Thus, the search for specific inhibitors of different T4SS components opens a novel approach to restrict plasmid dissemination. This review highlights recent biochemical and structural findings that shed new light on the molecular mechanisms of DNA and protein transport by T4SS. Based on these data, a model for pilus biogenesis and substrate transfer in conjugative systems is proposed. This model provides a renewed view of the mechanism that might help to envisage new strategies to curb the threating expansion of antibiotic resistance.
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Citations
Cites
Drugs for bad bugs: confronting the challenges of antibacterial discovery
Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512
Cited by
Horizontal transfer of antibiotic resistance genes in the human gut microbiome
McInnes, R. S., McCallum, G. E., Lamberte, L. E., & van Schaik, W. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.02.002 · Cited by 401
The application of the CRISPR-Cas system in antibiotic resistance
Tao, S., Chen, H., Li, N., & Liang, W. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s370869 · Cited by 147
Mobile antimicrobial resistance genes in probiotics
Tóth, A. G., Csabai, I., Judge, M. F., Maróti, G., Becsei, Á., Spisák, S., & Solymosi, N. (2021) · doi:10.1101/2021.05.04.442546 · Cited by 97
IMG/PR: a database of plasmids from genomes and metagenomes with rich annotations and metadata
Camargo, A. P., Call, L., Roux, S., Nayfach, S., Huntemann, M., Palaniappan, K., Ratner, A., Chu, K., Mukherjeep, S., Reddy, T. B. K., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkad964 · Cited by 87
Self-citationModels for Gut-Mediated Horizontal Gene Transfer by Bacterial Plasmid Conjugation
Ott, L. C., & Mellata, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.891548 · Cited by 32
Metadata
- Authors
- Cabezón, E., Ripoll-Rozada, J., Peña, A., de la Cruz, F., & Arechaga, I.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-09
- Volume
- 39
- Issue
- 1
- Pages
- n/a-n/a
- ISSN
- 0168-6445 (ISSN-L)
- OpenAlex
- W2152042464
- Cited by
- 286
- References
- 1
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cabezón, E., Ripoll-Rozada, J., Peña, A., de la Cruz, F., & Arechaga, I. (2014). Towards an integrated model of bacterial conjugation. FEMS Microbiology Reviews. https://doi.org/10.1111/1574-6976.12085
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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