Association between sleep architecture and glucose tolerance in children and adolescents 儿童及青少年的睡眠结构与糖耐量的关系
Abstract
BACKGROUND: Short sleep duration is a contributing factor for decreased insulin sensitivity and hyperglycemia. Sleep architecture represents a cyclical pattern of sleep that shifts between sleep Stages N1, N2, N3 (slow wave sleep) and Stage R (rapid eye movement sleep). The aim of the present study was to examine the association between sleep architecture and glucose and insulin metabolism in both normal weight and overweight/obese children and adolescents. METHODS: A total of 118 subjects participated in the study. Subjects under-went overnight polysomnography (PSG) when the percentage of total sleep time (% TST) spent at each sleep stage was recorded and an oral glucose tolerance test together was performed the next morning. We assessed glucose tolerance, insulin sensitivity and pancreatic β-cell function using 2-h glucose levels, the Matsuda index (IS(OGTT)), and insulin secretion-sensitivity index-2 (ISSI-2), respectively. RESULTS: After adjustment for age, gender, body mass index z-score, pubertal status, and obstructive apnea hypopnea index, Stage N3 (% TST) was positively associated with IS(OGTT), whereas Stage N1 (%TST) exerted an opposite effect on IS(OGTT). Higher sleep efficiency and longer TST were independently associated with lower 2-h glucose levels, higher ISSI-2 and/or higher IS(OGTT). CONCLUSIONS: Stage N3, sleep efficiency and TST were protective factors in maintaining glucose and insulin homeostasis; however, Stage N1 functioned in the opposite direction.
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- Authors
- Zhu, Y., Li, A. M., Au, C. T., Kong, A. P. S., Zhang, J., Wong, C. K., Chan, J. C. N., & Wing, Y. K.
- Affiliations
- Chinese University of Hong Kong (HK)
- Corresponding author
- Li, Albert Martin
- ORCID
- Venue
- Journal of Diabetes
- Publisher
- Wiley
- Published
- 2014-03-27
- Volume
- 7
- Issue
- 1
- Pages
- 10-15
- ISSN
- 1753-0393 (ISSN-L)
- 1753-0407
- OpenAlex
- W1495161574
- Cited by
- 42
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 3 · 2014: 2
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research Grant Committee (CUHK4465/06M)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep architecture, glucose tolerance, insulin sensitivity, slow-wave sleep, REM sleep, N1 sleep stage, sleep efficiency, total sleep time, beta-cell function, insulin secretion, childhood obesity, adolescents, oral glucose tolerance test, Matsuda index
- MeSH terms
- Adolescent, Blood Glucose, Child, Female, Glucose Tolerance Test, Homeostasis, Humans, Hyperglycemia, Insulin Resistance, Male, Obesity, Sleep Wake Disorders, Body Mass Index, Polysomnography, Insulin-Secreting Cells
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