Pain avoidance predicts disability and depressive symptoms three years later in individuals with whiplash complaints
Abstract
BACKGROUND: Longstanding symptoms due to whiplash are commonly associated with decreased levels of emotional and physical functioning. To date, there is strong empirical support for the relationship between psychological in/flexibility and pain-related functioning, but the predictive role for future health is largely unknown. Hence, the aim of this study was to investigate if psychological in/flexibility (i.e. avoidance and cognitive fusion) predicted pain disability and depressive symptoms 3 years later in individuals with whiplash complaints. METHODS: Data were collected at baseline and at a 3 year follow-up from 368 members of a national patient organization for people with whiplash-associated disorder. In a series of hierarchical regression analyses, background variables, pain related variables, psychological distress and psychological inflexibility at baseline were evaluated as predictors of levels of pain disability and depressive symptoms at follow-up. RESULTS: Results showed that psychological inflexibility, and more specifically avoidance, was a unique predictor of pain disability and depressive symptoms, also when controlling for background variables, pain related variables and psychological distress. Level of education was also found to predict both pain disability and symptoms of depression. Lastly, pain variability predicted pain disability, and anxiety predicted depressive symptoms. CONCLUSION: Pain avoidance significantly predicted pain disability and depressive symptoms 3 years later. Although tentative, results warrant more studies to further explore the importance of pain avoidance for future health.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This type of avoidance was recently shown to predict pain disability and depressive symptoms three years later.
“This type of avoidance was recently shown to predict pain disability and depressive symptoms three years later [17].”
From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [17]
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Statistical Analysis with Missing Data
Little, R. J. A., & Rubin, D. B. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/9781119013563 · Cited by 8,473 · see citing works
Acceptance and commitment therapy: model, processes and outcomes
Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006) · Behaviour Research and Therapy · doi:10.1016/j.brat.2005.06.006 · Cited by 6,587 · cited 2× · see citing works
“It is defined as ‘the inability to act effectively in accordance with personal values in the presence of negative private experiences, such as pain and distress’.(15) Psychological in/flexibility is considered to be subdivided into different psychological processes including avoidance of unpleasant experiences, and co…”
BackgroundFear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931 · see citing works
The Neck Disability Index: a study of reliability and validity.
Vernon, H. T., & Mior, S. A. (1991) · PubMed · Cited by 3,063 · see citing works
Herrmann, C. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(96)00216-4 · Cited by 2,885 · see citing works
Multiple imputation of discrete and continuous data by fully conditional specification
van Buuren, S. (2007) · Statistical Methods in Medical Research · doi:10.1177/0962280206074463 · Cited by 2,827 · see citing works
The fear-avoidance model of musculoskeletal pain: Current state of scientific evidence
Leeuw, M., Goossens, M. E. J. B., Linton, S. J., Crombez, G., Boersma, K., & Vlaeyen, J. W. S. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-006-9085-0 · Cited by 2,261 · see citing works
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092 · see citing works
Spitzer, W. O., Skovron, M. L., Salmi, L., Cassidy, J. D., DURANCEAU, J., Suissa, S., & Zeiss, E. E. (1995) · PubMed · Cited by 1,865 · see citing works
Fear-avoidance model of chronic musculoskeletal pain: 12 years on
Vlaeyen, J. W. S., & Linton, S. J. (2012) · Pain · doi:10.1016/j.pain.2011.12.009 · Cited by 1,281 · see citing works
The Pain Disability Index: psychometric properties
Tait, R. C., Chibnall, J. T., & Krause, S. (1990) · Pain · doi:10.1016/0304-3959(90)90068-o · Cited by 952 · see citing works
Behavioral Methods for Chronic Pain and Illness
Quimby, C. W. (1976) · Anesthesiology · doi:10.1097/00000542-197610000-00030 · Cited by 866 · see citing works
Performance of Some Resistant Rules for Outlier Labeling
Hoaglin, D. C., Iglewicz, B., & Tukey, J. W. (1986) · Journal of the American Statistical Association · doi:10.1080/01621459.1986.10478363 · Cited by 773 · see citing works
Hospital anxiety and depression scale (had): Some psychometric data for a swedish sample
Lisspers, J., Nygren, A., & Söderman, E. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb10164.x · Cited by 706 · see citing works
Learning to live with the pain: acceptance of pain predicts adjustment in persons with chronic pain
McCracken, L. M. (1998) · Pain · doi:10.1016/s0304-3959(97)00146-2 · Cited by 685 · see citing works
Acceptance and commitment therapy and mindfulness for chronic pain: Model, process, and progress.
McCracken, L. M., & Vowles, K. E. (2014) · American Psychologist · doi:10.1037/a0035623 · Cited by 627 · see citing works
Coping or acceptance? What to do about chronic pain
McCracken, L. M., & Eccleston, C. (2003) · Pain · doi:10.1016/s0304-3959(03)00202-1 · Cited by 591 · see citing works
(1987) · PubMed · Cited by 587 · see citing works
Performance of Some Resistant Rules for Outlier Labeling
Hoaglin, D. C., Iglewicz, B., & Tukey, J. W. (1986) · Journal of the American Statistical Association · doi:10.2307/2289073 · Cited by 524 · see citing works
Côté, P., Cassidy, J. D., Carroll, L., Frank, J. W., & Bombardier, C. (2001) · Spine · doi:10.1097/00007632-200110010-00020 · Cited by 390 · see citing works
A prospective study of acceptance of pain and patient functioning with chronic pain
McCracken, L. M., & Eccleston, C. (2005) · Pain · doi:10.1016/j.pain.2005.08.015 · Cited by 341 · see citing works
Acceptance and change in the context of chronic pain
McCracken, L. M., Carson, J. W., Eccleston, C., & Keefe, F. J. (2004) · Pain · doi:10.1016/j.pain.2004.02.006 · Cited by 322 · see citing works
McCracken, L. M., & Gutiérrez-Martínez, O. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.02.004 · Cited by 283 · see citing works
Viane, I., Crombez, G., Eccleston, C., Poppe, C., Devulder, J., Van Houdenhove, B., & De Corte, W. (2003) · Pain · doi:10.1016/s0304-3959(03)00291-4 · Cited by 282 · see citing works
Wicksell, R. K., Olsson, G. L., & Hayes, S. C. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.05.001 · Cited by 259 · cited 1× · see citing works
“Statistical evaluations of the instrument have shown satisfactory psychometric properties, including test–retest reliability, sensitivity to change(31) and ability to detect indirect effects.(24) In the current sample Chronbach alpha was 0.”
MethodSelf-citationAcceptance and commitment therapy for fibromyalgia: A randomized controlled trial.
Wicksell, R. K., Kemani, M., Jensen, K., Kosek, E., Kadetoff, D., Sorjonen, K., Ingvar, M., & Olsson, G. L. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00224.x · Cited by 244 · see citing works
Self-citationWicksell, R. K., Ahlqvist, J., Bring, A., Melin, L., & Olsson, G. L. (2008) · Cognitive Behaviour Therapy · doi:10.1080/16506070802078970 · Cited by 235 · see citing works
Self-citationWalton, D. M., MacDermid, J. C., Giorgianni, A. A., Mascarenhas, J. C., West, S. C., & Zammit, C. A. (2013) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2013.4507 · Cited by 233 · see citing works
The development of psychological changes following whiplash injury
Sterling, M. M., Kenardy, J. A., Jull, G. A., & Vicenzino, B. (2003) · Pain · doi:10.1016/j.pain.2003.09.013 · Cited by 216 · see citing works
Wicksell, R. K., Renöfält, J., Olsson, G. L., Bond, F. W., & Melin, L. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.08.003 · Cited by 193 · see citing works
Self-citationBergström, G., Jensen, I. B., Bodin, L., Linton, S. J., Nygren, Å. L., & Carlsson, S. G. (1998) · Pain · doi:10.1016/s0304-3959(97)00210-8 · Cited by 186 · see citing works
Vowles, K. E., Witkiewitz, K., Sowden, G., & Ashworth, J. (2014) · The Journal of Pain · doi:10.1016/j.jpain.2013.10.002 · Cited by 181 · see citing works
Wicksell, R. K., Lekander, M., Sorjonen, K., & Olsson, G. L. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2009.11.015 · Cited by 176 · see citing works
Self-citationSöderlund, A., Olerud, C., & Lindberg, P. (2000) · Clinical Rehabilitation · doi:10.1191/0269215500cr348oa · Cited by 136 · see citing works
Wicksell, R. K., Olsson, G. L., & Melin, L. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2008.09.003 · Cited by 135 · see citing works
Self-citationAcute and chronic whiplash disorders - a review
Sterner, Y., & Gerdle, B. U. C. (2004) · Journal of Rehabilitation Medicine · doi:10.1080/16501970410030742 · Cited by 122 · see citing works
Ritchie, C., Hendrikz, J. K., Kenardy, J. A., & Sterling, M. M. (2013) · Pain · doi:10.1016/j.pain.2013.07.001 · Cited by 120 · see citing works
Williams, M. A., Williamson, E. M., Gates, S., Lamb, S. E., & Cooke, M. W. (2007) · Spine · doi:10.1097/brs.0b013e31815b6565 · Cited by 89 · see citing works
A population study of anxiety and depression among persons who report whiplash traumas
Wenzel, H. G., Haug, T. T., Mykletun, A., & Dahl, A. A. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00323-9 · Cited by 82 · see citing works
Styrke, J., Stålnacke, B., Bylund, P., et al. (2012) · PM&R · doi:10.1016/j.pmrj.2012.05.010 · Cited by 65 · see citing works
Kemani, M. K., Olsson, G. L., Lekander, M., Hesser, H., Andersson, E., & Wicksell, R. K. (2015) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000203 · Cited by 61 · see citing works
Self-citationThe long-term prognosis of whiplash-associated disorders (WAD)
Olivegren, H., Jerkvall, N., Hagström, Y., et al. (1999) · European Spine Journal · doi:10.1007/s005860050189 · Cited by 30 · see citing works
Prevalence and Long-Term Disability Following Whiplash-Associated Disorder
Galasko, C. S. B., Murray, P. A., & Pitcher, M. (2000) · Journal of Musculoskeletal Pain · doi:10.1300/j094v08n01_03 · Cited by 21 · see citing works
Otte, A. (2012) · Springer eBooks · doi:10.1007/978-3-642-28356-7 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Psychological Flexibility as a Resilience Factor in Individuals with Chronic Pain
Gentili, C., Rickardsson, J., Zetterqvist, V., Simons, L. E., Lekander, M., & Wicksell, R. K. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02016 · Cited by 148 · see citing works
Self-citationHedman-Lagerlöf, M., Andersson, E., Hedman-Lagerlöf, E., Wicksell, R. K., Flink, I., & Ljótsson, B. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103478 · Cited by 36 · see citing works
Self-citationAcceptance & Commitment Therapy for ME/CFS (Chronic Fatigue Syndrome) – A feasibility study
Jonsjö, M. A., Wicksell, R. K., Holmström, L., Andreasson, A., & Olsson, G. L. (2019) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2019.02.008 · Cited by 27 · see citing works
Self-citationRickardsson, J., Zetterqvist, V., Kemani, M. K., Holmström, L., Andersson, E., & Wicksell, R. K. (2019) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2019.08.009 · Cited by 19 · see citing works
Self-citationKarshikoff, B., Åström, J., Holmström, L., Lekander, M., Kemani, M. K., & Wicksell, R. K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092285 · Cited by 6 · see citing works
“This type of avoidance was recently shown to predict pain disability and depressive symptoms three years later [17].”
BackgroundSelf-citation
- Authors
- Zetterqvist, V., Holmström, L., Maathz, P., & Wicksell, R. K.
- Affiliations
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Zetterqvist, V.
- Venue
- Acta Anaesthesiologica Scandinavica
- Publisher
- Wiley
- Published
- 2017-02-23
- Volume
- 61
- Issue
- 4
- Pages
- 445-455
- ISSN
- 0001-5172 (ISSN-L)
- 1399-6576
- OpenAlex
- W2590945555
- Cited by
- 13
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 5
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Anaesthesiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kommunfullmäktige, Stockholms Stad
- Karolinska Institutet
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Keywords
- whiplash-associated disorders, pain avoidance, psychological inflexibility, cognitive fusion, pain-related disability, depressive symptoms, long-term outcomes, pain variability, anxiety, educational attainment, psychological distress
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Cognition, Depression, Disability Evaluation, Educational Status, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Pain, Pain Measurement, Predictive Value of Tests, Stress, Psychological, Whiplash Injuries, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review