Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
De Cecco, Marco, Criscione, Steven W., Peckham, Edward J., Hillenmeyer, Sara, Hamm, Eliza A., Manivannan, Jayameenakshi, Peterson, Abigail L., Kreiling, Jill A., Neretti, Nicola, Sedivy, John M.·2013·Aging Cell
Cited by (458)
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- Roles of piRNA Pathway Components Piwi and Aubergine In Drosophila melanogaster Female Germline DevelopmentXing Ma · 2014 · KU ScholarWorks (The University of Kansas)
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- The Origins of AgeingBernard Swynghedauw · 2019 · Practical issues in geriatrics
- The Effects of Exercise on LINE-1 RegulationMatthew A. Romero · 2019
- Line-1 Retrotransposition and the Impact on Aging Rodent Skeletal Muscle TissuePetey W. Mumford · 2019
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- LINE-1 RNA Expression is Higher in Older Human Skeletal Muscle but Decreases With Endurance Exercise and Physical ActivityPaul A. Roberson · 2019
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- Aging-associated changes in metabolic regulation of epigenetic modifications and gene expressionPoonam Bheda · 2021 · Elsevier eBooks
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- A centromeric RNA-associated protein complex affects germ line development in Drosophila melanogasterSaskia Höcker, Izlem Su Akan, Alexander M. Simon, Kerem Yildirim, Lili Anna Kenéz, Ingrid Lohmann, Sylvia Erhardt · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Age-dependent transcriptional and epigenetic alterations in mouse hepatocytesSharma, Ankur · 2021 · DR-NTU (Nanyang Technological University)
- Faculty Opinions recommendation of L1 drives IFN in senescent cells and promotes age-associated inflammation.Michael Zhang, Zhenyu Xuan · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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- Epigenetics of agingChristina Pagiatakis, Rosalba Gornati, Roberto Papait · 2023 · Elsevier eBooks
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- Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingYi-Ting Tsai, Nogayhan Seymen, Ian Richard Thompson, Xinchen Zou, Warisha Mumtaz, Sıla Gerlevik, Ghulam Jeelani Mufti, Mohammad Mahdi Karimi · 2024 · eLife
- Transposable Element (TE) insertion predictions from RNAseq inputs and TE impact on RNA splicing and gene expression in Drosophila brain transcriptomesMd Fakhrul Azad, Tong Tong, Nelson C. Lau · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- The number of Y chromosomes is positively associated with transposable element expression in humans, in line with the toxic Y hypothesisAnna-Sophie Fiston-Lavier · 2024 · Peer Community In Genomics
- Neurological Impact of Type I Interferon DysregulationAlessio Mylonas · 2024 · IntechOpen eBooks
- Author response: Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingYi-Ting Tsai, Nogayhan Seymen, Ian Richard Thompson, Xinchen Zou, Warisha Mumtaz, Sıla Gerlevik, Ghulam Jeelani Mufti, Mohammad Mahdi Karimi · 2024 · eLife
- eLife Assessment: Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingFlorent Ginhoux · 2024 · eLife
- Reviewer #1 (Public Review): Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingYi-Ting Tsai, Nogayhan Seymen, I Richard Thompson · 2024 · eLife
- Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingYi-Ting Tsai, Nogayhan Seymen, Ian Richard Thompson, Xinchen Zou, Warisha Mumtaz, Sıla Gerlevik, Ghulam Jeelani Mufti, Mohammad Mahdi Karimi · 2024 · eLife
- Transposable element small and long RNAs in aging brains and implications in Huntington’s and Parkinson’s diseaseGargi Dayama, Shruti Gupta, Brianne K. Connizzo, Adam Thomas Labadorf, Richard H. Myers, Nelson C. Lau · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- De-repression of Transposable Elements by Histone Hyperacetylation Leads to Sterile Inflammation in PreeclampsiaMadapura M. Pradeepa, Manthan Patel, Ahmed Ali, Adrianna Dąbrowska, Fanny Boulet, Rashmi Kulkarni, Charlie Ince, Ajay Sinha · 2025 · Research Square
- Fragmentation of nucleoli in senescent cancer cells is associated with increased levels of polyadenylated transcripts derived from noncoding regions of rDNA unitsJana Sochorová, Emı́lie Lukášová, Eva Polanská, Kateřina Řehůřková, Aleš Kovařı́k · 2025 · European Biophysics Journal
- Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brainTom Bonnifet, Sandra Sinnassamy, Olivia Massiani-Beaudoin, Philippe Mailly, Héloïse Monnet, Damarys Loew, Bérangère Lombard, Nicolas Servant, Rajiv L. Joshi, Julia Fuchs · 2025 · eLife
- Ageing versus developmental silencing: Answers from the epigenomeKirsten C. Sadler, Mekayla A. Storer, Nermin Sumru Bayin · 2025 · FEBS Journal
- Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brainTom Bonnifet, Sandra Sinnassamy, Olivia Massiani-Beaudoin, Philippe Mailly, Héloïse Monnet, Damarys Loew, Bérangère Lombard, Nicolas Servant, Rajiv L. Joshi, Julia Fuchs · 2025 · eLife
- Transposable Elements and Their Roles in Genome ArchitectureSampriti Majumder, Snata Pandey, Sugopa Sengupta · 2025 · Epigenetics and human health
- Transposable Elements as Drivers of Age-Related Neurodegenerative DiseaseChiara Scopa, Megan Muench, Davide Trotti · 2025 · Epigenetics and human health
- Transposable elements in aging: From biomarkers to effectorsAlejandro Fuentes-Iglesias, Raquel García-Vílchez, Diana Guallar · 2025 · Advances in genetics
- Exploring the association between DNA methylation and pancreatic cancer susceptibility through epigenome-wide Mendelian randomization and multi-omics data integrationPengxu Wang, Rong Feng, Fubao Liu · 2025 · Epigenetics
- Transposable elements as dynamic regulators of skeletal muscle development, regeneration and agingMeijun Song, Wenjie Duan, Duomin Liang, Dinghui Dai, Li Li, Hongping Zhang · 2025 · Genomics
- Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological agingJimena Meneses-Plascencia, Ericka Moreno‐Méndez, Diana Ascencio, Cesia Pérez-Aguilar, Michelle Munguía-Figueroa, Cei Abreu-Goodger, Soledad Funes, Alexander DeLuna · 2026 · Mechanisms of Ageing and Development
- Étude des altérations du programme de réplication lors du vieillissement cellulaire : peuvent-elles être reprogrammées ?Hélène Schwerer · 2014 · theses.fr (ABES)
- Role of thrombopoietin in DNA repair an genomic integrity in hematopoietic stem cellsDaniela Barbieri · 2017 · theses.fr (ABES)
- Generation of antisense RNAs at convergent gene loci in cells undergoing senescenceMaharshi Krishna Deb · 2016 · theses.fr (ABES)
- Analyse fonctionnelle du variant d’histone H2A.J impliqué dans le développement d’un phénotype pro-inflammatoire en sénescence induite par des dommages à l’ADNAdèle Mangelinck · 2020 · theses.fr (ABES)
- Implication du gène Dicer1 dans le vieillissement et ses pathologies chez la sourisAurore de Cauwer · 2020 · theses.fr (ABES)
- L1 retrotransposon activity in muscle cellsPaula Peressini Lopez · 2020 · theses.fr (ABES)
- Découverte d'une sénescence associée à un phénotype sécrétoire déclenchée par les défauts mécaniques de la cellule endothéliale lors de la perte de CCM2 dans un modèle de cavernome cérébralDaphné Vannier · 2020 · theses.fr (ABES)
- Rôles de très longs ARNs non codants intergéniques dans la réorganisation 3D du génome au cours de la sénescenceJulien Ouvrard · 2023 · theses.fr (ABES)
- Étude de l'évolution des interactions moléculaires chez les Eucaryotes par des méthodes de comparaison de réseaux dans le but d'identifier des processus ancestraux partagés associés au vieillissementHugo Bonnefous · 2025 · theses.fr (ABES)
- Characterization of Cellular Senescence in Primary Human AstrocytesTrenton A. Woodham, Maxfield M. G. Kelsey, John M. Sedivy · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Locus-specific LINE-1 mRNA expression reflects cell-type- and stimulus-specific senescence statesMinh N. Tran, Sihan Liu, Melody Baddoo, Emily C. Stow, Sudesh K Srivastav, Victoria P. Belancio · 2026 · Nucleic Acids Research
- Repair and misrepair of telomeric DNA in dynamic interactions with PML nuclear bodies and lamin B1 in doxorubicin-treated cancer cellsKristīne Salmiņa, Fēlikss Rūmnieks, Dace Pjanova, Ninel Miriam Vainshelbaum, Jekaterina A. Erenpreisa · 2026 · Nucleus
- Epigenetic drift and LINE-1 activation in aging brain: Implications for neurodegenerative diseaseAlkinoos A Armoundas, Christina Piperi · 2026 · Mechanisms of Ageing and Development
- SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying ComplexesXiaona Wang, Tianbo Li, Huanyin Tang, Meng Xiao Liu, Qinghua Peng, Xiao Huang, Zhiyong Mao, Ying Jiang, Anke Geng · 2026 · Aging Cell
- Aging and Reproductive Cancers: An Integrative View on Cell-Free DNA and Transposable ElementsMonia Cecati, Salvatore Vaiasicca, Laura Cianfruglia, Stefania Fumarola, Roberto Campagna, Francesca Marchegiani, Maurizio Cardelli · 2026 · Frontiers in Bioscience-Landmark
- The therapeutic potential of transposable element activity modulationGabriele Morelli, Marco D’Onghia, Arianna Mangiavacchi, Valerio Orlando · 2026 · EMBO Molecular Medicine
- Chromatin signaling in aging and cellular senescenceLaurence M. Gagné, Florence Couteau, Frédérick A. Mallette · 2026 · Elsevier eBooks