Neretti, Nicola

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,255

LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation

Simon, M., Van Meter, M., Ablaeva, J., Ke, Z., Gonzalez, R. S., Taguchi, T., De Cecco, M., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 498

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

De Cecco, M., Criscione, S. W., Peckham, E. J., Hillenmeyer, S., Hamm, E. A., Manivannan, J., Peterson, A. L., Kreiling, J. A., Neretti, N., & Sedivy, J. M. (2013) · Aging Cell

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 459

SenNet recommendations for detecting senescent cells in different tissues

Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., et al. (2024) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 408

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Ogrodnik, M., Evans, S. A., Fielder, E., Victorelli, S., Kruger, P., Salmonowicz, H., Weigand, B. M., Patel, A. D., Pirtskhalava, T., Inman, C. L., et al. (2021) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 405

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

De Cecco, M., Criscione, S. W., Peterson, A. L., Neretti, N., Sedivy, J. M., & Kreiling, J. A. (2013) · Aging

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 365

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

Liu, Y.-C., Li, F., Handler, J., Huang, C. R. L., Xiang, Y., Neretti, N., Sedivy, J. M., Zeller, K. I., & Dang, C. V. (2008) · PLoS ONE

Biochemical and Molecular ResearchGenomics and Chromatin Dynamics

Cited by 317

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 293

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

Ito, T., Teo, Y. V., Evans, S. A., Neretti, N., & Sedivy, J. M. (2018) · Cell Reports

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 265

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

Wood, J. G., Jones, B. C., Jiang, N., Chang, C., Hosier, S., Wickremesinghe, P., Garcia, M., Hartnett, D. A., Burhenn, L., Neretti, N., et al. (2016) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsChromosomal and Genetic Variations

Cited by 214

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Lagnado, A., Leslie, J., Ruchaud‐Sparagano, M., Victorelli, S., Hirsova, P., Ogrodnik, M., Collins, A. L., Vizioli, M. G., Habiballa, L., Saretzki, G., et al. (2021) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 211

Chromatin remodeling in the aging genome of Drosophila

Wood, J. G., Hillenmeyer, S., Lawrence, C., Chang, C., Hosier, S., Lightfoot, W., Mukherjee, E., Jiang, N., Schorl, C., Brodsky, A. S., et al. (2010) · Aging Cell

Genomics and Chromatin DynamicsGenetics, Aging, and Longevity in Model Organisms

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Reorganization of chromosome architecture in replicative cellular senescence

Criscione, S. W., De Cecco, M., Siranosian, B., Zhang, Y., Kreiling, J. A., Sedivy, J. M., & Neretti, N. (2016) · Science Advances

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

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Notch Signaling Mediates Secondary Senescence

Teo, Y. V., Rattanavirotkul, N., Olova, N., Salzano, A., Quintanilla, A., Tarrats, N., Kiourtis, C., Müller, M., Green, A. R., Adams, P. D., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Spatial mapping of cellular senescence: emerging challenges and opportunities

Gurkar, A. U., Gerencser, A. A., Mora, A. L., Nelson, A. C., Zhang, A. R., Lagnado, A. B., Enninful, A., Benz, C., Furman, D., Beaulieu, D., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

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The Chromatin Landscape of Cellular Senescence

Criscione, S. W., Teo, Y. V., & Neretti, N. (2016) · Trends in Genetics

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

Jiang, N., Du, G., Tobias, E., Wood, J. G., Whitaker, R., Neretti, N., & Helfand, S. L. (2013) · Aging

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

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The functional impact of nuclear reorganization in cellular senescence

Rocha, A., Dalgarno, A., & Neretti, N. (2022) · Briefings in Functional Genomics

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

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