Sedivy, John M.

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 3,225

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 2,803

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 2,165

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

Herbig, U., Jobling, W. A., Chen, B. P. C., Chen, D. J., & Sedivy, J. M. (2004) · Molecular Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,344

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,255

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,101

Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

Brown, J. P., Wei, W., & Sedivy, J. M. (1997) · Science

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 804

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 649

Loss of epigenetic information as a cause of mammalian aging

Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 643

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 571

LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation

Simon, M., Van Meter, M., Ablaeva, J., Ke, Z., Gonzalez, R. S., Taguchi, T., De Cecco, M., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 498

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

Bowman, T., Broome, M. A., Sinibaldi, D., Wharton, W., Pledger, W. J., Sedivy, J. M., Irby, R., Yeatman, T., Courtneidge, S. A., & Jove, R. (2001) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 488

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

De Cecco, M., Criscione, S. W., Peckham, E. J., Hillenmeyer, S., Hamm, E. A., Manivannan, J., Peterson, A. L., Kreiling, J. A., Neretti, N., & Sedivy, J. M. (2013) · Aging Cell

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 459

The role of retrotransposable elements in ageing and age-associated diseases

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 446

Guidelines for minimal information on cellular senescence experimentation in vivo

Ogrodnik, M., Carlos Acosta, J., Adams, P. D., d’Adda di Fagagna, F., Baker, D. J., Bishop, C. L., Chandra, T., Collado, M., Gil, J., Gorgoulis, V., et al. (2024) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 376

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

De Cecco, M., Criscione, S. W., Peterson, A. L., Neretti, N., Sedivy, J. M., & Kreiling, J. A. (2013) · Aging

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 365

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Chini, C. C. S., Peclat, T. R., Warner, G. M., Kashyap, S., Espindola-Netto, J. M., de Oliveira, G. C., Gomez, L. S., Hogan, K. A., Tarragó, M. G., Puranik, A. S., et al. (2020) · Nature Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 349

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

Liu, Y.-C., Li, F., Handler, J., Huang, C. R. L., Xiang, Y., Neretti, N., Sedivy, J. M., Zeller, K. I., & Dang, C. V. (2008) · PLoS ONE

Biochemical and Molecular ResearchGenomics and Chromatin Dynamics

Cited by 317

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 293

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

Ito, T., Teo, Y. V., Evans, S. A., Neretti, N., & Sedivy, J. M. (2018) · Cell Reports

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 265

The number of p16INK4a positive cells in human skin reflects biological age

Waaijer, M. E. C., Parish, W. E., Strongitharm, B. H., van Heemst, D., Slagboom, P. E., de Craen, A. J. M., Sedivy, J. M., Westendorp, R. G. J., Gunn, D. A., & Maier, A. B. (2012) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 264

Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with Camptothecin

Han, Z., Wei, W., Dunaway, S., Darnowski, J. W., Calabresi, P., Sedivy, J., Hendrickson, E. A., Balan, K. V., Pantazis, P., & Wyche, J. H. (2002) · Journal of Biological Chemistry

Cancer therapeutics and mechanismsCancer-related Molecular Pathways

Cited by 262

Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts

Wei, W., Hemmer, R. M., & Sedivy, J. M. (2001) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 217