Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
Open accessPublished version of a preprint
Abstract
Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescence-associated secretory phenotype (SASP). Emerging evidence suggests that the presence of these proinflammatory and matrix-degrading molecules has deleterious effects in a variety of tissues. In the current study, we demonstrated in a transgenic mouse model that early removal of senescent cells induced upon elevated intraocular pressure (IOP) protects unaffected RGCs from senescence and apoptosis. Visual evoked potential (VEP) analysis demonstrated that remaining RGCs are functional and that the treatment protected visual functions. Finally, removal of endogenous senescent retinal cells after IOP elevation by a treatment with senolytic drug dasatinib prevented loss of retinal functions and cellular structure. Senolytic drugs may have the potential to mitigate the deleterious impact of elevated IOP on RGC survival in glaucoma and other optic neuropathies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a mouse model, dasatinib prevented glaucoma-dependent loss of retinal functions and cellular structure.
“Although a study in a mouse model showed that dasatinib prevented glaucoma-dependent loss of retinal functions and cellular structure, 41 a retrospective study assessing the effects of senolytic drugs on vision in 28 patients with glaucoma showed that senolytic exposure did not affect visual acuity or intraocular pressure, and did not have toxic effects.74”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works
The Pathophysiology and Treatment of Glaucoma: A Review
Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210 · see citing works
Self-citationClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Mi, H., Muruganujan, A., Ebert, D., Huang, X., & Thomas, P. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1038 · Cited by 2,950 · see citing works
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works
Jeon, O. H., Kim, C., Laberge, R.-M., Demaria, M., Rathod, S., Vasserot, A. P., Chung, J. W., Kim, D. H., Poon, Y., David, N., et al. (2017) · Nature Medicine · doi:10.1038/nm.4324 · Cited by 1,515 · see citing works
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195 · see citing works
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003 · see citing works
Wiggs, J. L., & Pasquale, L. R. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx184 · Cited by 380 · see citing works
Boland, M. V., Ervin, A., Friedman, D. S., JAMPEL, H. D., Hawkins, B. S., Vollenweider, D. J., Chelladurai, Y., Ward, D., Suarez‐Cuervo, C., & Robinson, K. A. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-4-201302190-00008 · Cited by 303 · see citing works
Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis
Killer, H., & Pircher, A. (2018) · Eye · doi:10.1038/s41433-018-0042-2 · Cited by 262 · see citing works
Ganglion cell contributions to the rat full‐field electroretinogram
Bui, B. V., & Fortune, B. A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052738 · Cited by 239 · see citing works
Electrophysiological assessment of retinal ganglion cell function
Porciatti, V. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.05.008 · Cited by 193 · see citing works
Sihota, R., Angmo, D., Ramaswamy, D., & Dada, T. (2018) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_1130_17 · Cited by 182 · see citing works
Evangelho, K. D. S., Mogilevskaya, M., Losada-Barragán, M., & Vargas-Sánchez, K. (2017) · International Ophthalmology · doi:10.1007/s10792-017-0795-9 · Cited by 170 · see citing works
Delayed Functional Loss in Glaucoma LII Edward Jackson Memorial Lecture
Brubaker, R. F. (1996) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)75421-2 · Cited by 143 · see citing works
The visual evoked potential in the mouse—Origins and response characteristics
Ridder, W. H., & Nusinowitz, S. (2005) · Vision Research · doi:10.1016/j.visres.2005.09.006 · Cited by 126 · see citing works
P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
Skowronska‐Krawczyk, D., Zhao, L., Zhu, J., Weinreb, R. N., Cao, G., Luo, J., Flagg, K., Patel, S. H., Wen, C. H., Krupa, M., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.027 · Cited by 102 · see citing works
Self-citationCharacterizing the “POAGome”: A bioinformatics-driven approach to primary open-angle glaucoma
Danford, I. D., Verkuil, L. D., Choi, D., Collins, D. W., Gudiseva, H. V., Uyhazi, K. E., Lau, M. K., Kanu, L. N., Grant, G. R., Chavali, V. R. M., et al. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.02.001 · Cited by 90 · see citing works
Wnt signaling potentiates nevogenesis
Pawlikowski, J. S., McBryan, T., van Tuyn, J., Drotar, M. E., Hewitt, R. N., Maier, A. B., King, A., Blyth, K., Wu, H. G., & Adams, P. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303491110 · Cited by 68 · see citing works
Chromosome 9p21 primary open‐angle glaucoma susceptibility locus: a review
Ng, S. K., Casson, R. J., Burdon, K. P., & Craig, J. E. (2013) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12234 · Cited by 41 · see citing works
To stay young, kill zombie cells
Scudellari, M. (2017) · Nature · doi:10.1038/550448a · Cited by 41 · see citing works
P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury
Li, L. U., Zhao, Y., & Zhang, H. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.169 · Cited by 34 · see citing works
DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma
Burdon, K. P., Awadalla, M. S., Mitchell, P., Wang, J. J., White, A. J. R., Keane, M. C., Souzeau, E., Graham, S. L., Goldberg, I., Healey, P. R., et al. (2017) · Ophthalmic Genetics · doi:10.1080/13816810.2017.1413659 · Cited by 21 · see citing works
(2019) · doi:10.1101/684811 · Cited by 4 · see citing works
Self-citationKrawczyk, M., Rocha, L. R., Nguyen Huu, V. A., et al. (2019) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.6075/j0707ztm · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Cellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,105 · see citing works
A Senescence-Centric View of Aging: Implications for Longevity and Disease
Borghesan, M., Hoogaars, W. M. H., Varela-Eirin, M., Talma, N., & Demaria, M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.002 · Cited by 267 · see citing works
Lee, K. S., Lin, S., Copland, D. A., Dick, A. D., & Liu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02088-0 · Cited by 150 · see citing works
Cellular senescence in brain aging and neurodegeneration
dos Santos, L. M., Trombetta-Lima, M., Eggen, B. J. L., & Demaria, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102141 · Cited by 158 · see citing works
The costs and benefits of senotherapeutics for human health
Raffaele, M., & Vinciguerra, M. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00300-7 · Cited by 140 · see citing works
Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis
Kitazawa, K., Inomata, T., Shih, K. C., Hughes, J. B., Bozza, N., Tomioka, Y., Numa, K., Yokoi, N., Campisi, J., Dana, R., et al. (2022) · The Ocular Surface · doi:10.1016/j.jtos.2022.06.004 · Cited by 85 · see citing works
Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions
Campello, L., Singh, N., Advani, J., Mondal, A. K., Corso‐Díaz, X., & Swaroop, A. (2021) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100419-114940 · Cited by 67 · see citing works
Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
Terao, R., Ahmed, T., Suzumura, A., & Terasaki, H. (2022) · Antioxidants · doi:10.3390/antiox11112189 · Cited by 59 · see citing works
The Emerging Role of Senescence in Ocular Disease
Sreekumar, P. G., Hinton, D. R., & Kannan, R. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2583601 · Cited by 62 · see citing works
Aging and injury drive neuronal senescence in the dorsal root ganglia
Donovan, L. J., Brewer, C. L., Bond, S. F., Laslavic, A. M., Lopez, A. P., Colman, L., Jordan, C. E., Hansen, L., Gonzalez, O. C., Pujari, A., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01954-x · Cited by 57 · see citing works
Stress induced aging in mouse eye
Xu, Q., Rydz, C., Huu, V. A. N., Rocha, L., Torre, C. P. L., Lee, I., Cho, W., Jabari, M., Donello, J. E., Lyon, D. C., et al. (2022) · Aging Cell · doi:10.1111/acel.13737 · Cited by 50 · see citing works
Self-citationChoi, S., Keun-young Kim, A., Perkins, G. A., Phan, S., Edwards, G., Xia, Y., Kim, J., Skowronska‐Krawczyk, D., Weinreb, R. N., Ellisman, M. H., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101703 · Cited by 50 · see citing works
Self-citationLiu, Y., Liu, X., Chen, X., Yang, Z., Chen, J., Zhu, W., Li, Y., Wen, Y., Deng, C., Gu, C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311028121 · Cited by 43 · see citing works
Sreekumar, P. G., Reddy, S. T., Hinton, D. R., & Kannan, R. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2021.108918 · Cited by 41 · see citing works
de Luzy, I. R., Lee, M. K., Mobley, W. C., & Studer, L. (2024) · Nature Aging · doi:10.1038/s43587-024-00586-3 · Cited by 36 · see citing works
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary
Hense, J. D., Garcia, D. N., Isola, J. V. V., Rincón, J. A. A., Zanini, B. M., Prosczek, J. B., Stout, M. B., Mason, J. B., Walsh, P. T., Brieño‐Enríquez, M. A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00573-9 · Cited by 36 · see citing works
Martínez‐Alberquilla, I., Gasull, X., Pérez-Luna, P., Seco-Mera, R., Ruiz‐Alcocer, J., & Crooke, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101553 · Cited by 35 · see citing works
Context‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, V., Cisneros, A., Cobos, A. C., Tarrega, A. B., Oñate, C. S., Perdiguero, E., Serrano, A. L., & Muñoz‐Cánoves, P. (2023) · The FEBS Journal · doi:10.1111/febs.16573 · Cited by 34 · see citing works
Modeling complex age-related eye disease
Becker, S., L'Ecuyer, Z., Jones, B. W., Zouache, M. A., McDonnell, F. S., & Vinberg, F. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101247 · Cited by 31 · see citing works
A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment
Saleh, T., Greenberg, E. F., Faber, A. C., Harada, H., & Gewirtz, D. A. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2219 · Cited by 26 · see citing works
p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries
Kaur, G., Sundar, I. K., & Rahman, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094834 · Cited by 26 · see citing works
Cellular senescence and frailty: a comprehensive insight into the causal links
Marcozzi, S., Bigossi, G., Giuliani, M. E., Giacconi, R., Piacenza, F., Cardelli, M., Brunetti, D., Segala, A., Valerio, A., Nisoli, E., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00960-w · Cited by 24 · see citing works
Innate immunity dysregulation in aging eye and therapeutic interventions
Das, S., Ahmad, Z., Suryawanshi, A. S., & Kumar, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101768 · Cited by 24 · see citing works
Evaluating the neuroprotective impact of senolytic drugs on human vision
El-Nimri, N. W., Moore, S. M., Zangwill, L. M., Proudfoot, J. A., Weinreb, R. N., Skowronska-Krawczyk, D., & Baxter, S. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-78802-4 · Cited by 22 · see citing works
Self-citationMeiners, F., Hinz, B., Boeckmann, L., Secci, R., Sueto, S. O. B., Kuepfer, L., Fuellen, G., & Barrantes, I. (2024) · Scientific Reports · doi:10.1038/s41598-024-55870-4 · Cited by 21 · see citing works
Sirt6 protects retinal ganglion cells and optic nerve from degeneration during aging and glaucoma
Xia, F., Shi, S., Palacios, E., Liu, W., Buscho, S. E., Li, J., Huang, S., Vizzeri, G., Dong, X. C., Motamedi, M., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.04.030 · Cited by 20 · see citing works
Cellular senescence in vivo: From cells to tissues to pathologies
Kumar, A., Bano, D., & Ehninger, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111308 · Cited by 19 · see citing works
Does senescence play a role in age-related macular degeneration?
Malek, G., Campisi, J., Kitazawa, K., Webster, C. M., Lakkaraju, A., & Skowronska‐Krawczyk, D. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109254 · Cited by 18 · see citing works
Self-citationCellular senescence and ophthalmic diseases: narrative review
Soleimani, M., Cheraqpour, K., Koganti, R., & Djalilian, A. R. (2023) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-023-06070-9 · Cited by 18 · see citing works
Review on potential effects of traditional Chinese medicine on glaucoma
Qi, S.-M., Zhang, J.-T., Zhu, H., Wang, Z., & Li, W. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.116063 · Cited by 17 · see citing works
Chen, J., Yuan, X., Zhou, X., Xu, J., Zhang, X., & Duan, X. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01723-w · Cited by 16 · see citing works
Sato, K., Saigusa, D., Kokubun, T., Fujioka, A., Feng, Q., Saito, R., Uruno, A., Matsukawa, N., Ohno‐Oishi, M., Kunikata, H., et al. (2023) · npj Aging · doi:10.1038/s41514-023-00124-2 · Cited by 13 · see citing works
Wu, J., Liu, X., Liu, Y., Su, W., & Zhuo, Y. (2025) · Bioengineering · doi:10.3390/bioengineering12060563 · Cited by 13 · see citing works
Hong, S., Weerasinghe-Mudiyanselage, P. D. E., Kang, S., Moon, C., & Shin, T. (2023) · Animal Cells and Systems · doi:10.1080/19768354.2023.2264354 · Cited by 12 · see citing works
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis
Lei, L., Cheng, Y., Yin, A., Han, J.-M., Wu, G., Yang, F., Wang, Q., Wang, J., Liu, R., Li, H., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00487-4 · Cited by 13 · see citing works
Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay
Rubio‐Tomás, T., & Tavernarakis, N. (2022) · Biogerontology · doi:10.1007/s10522-022-09989-4 · Cited by 11 · see citing works
Girkin, C. A., Strickland, R. G., Somerville, M. M., Garner, M. A., Grossman, G., Blake, A., Kumar, N., Ianov, L., Fazio, M. A., Clark, M. E., et al. (2024) · Vision Research · doi:10.1016/j.visres.2024.108465 · Cited by 10 · see citing works
Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells
Low, J., Chan, B., & Tay, A. K. P. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107990 · Cited by 11 · see citing works
Cellular senescence mediates retinal ganglion cell survival regulation post‐optic nerve crush injury
Yao, Y., Bin, X., Xu, Y., Chen, S., Chen, S., Yuan, X., Cao, Y., & Ng, T. K. (2024) · Cell Proliferation · doi:10.1111/cpr.13719 · Cited by 10 · see citing works
Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53M214K mutants
Şerifoğlu, N., Lopes-Bastos, B., & Ferreira, M. G. (2024) · Scientific Reports · doi:10.1038/s41598-024-56153-8 · Cited by 9 · see citing works
Recent Advancement in Elimination Strategies and Potential Rejuvenation Targets of Senescence
Kureel, S. K., Blair, B., & Sheetz, M. P. (2023) · Advanced Biology · doi:10.1002/adbi.202300461 · Cited by 8 · see citing works
Chen, Y., Jiang, F., Zeng, Y., & Zhang, M. (2025) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2025.03.004 · Cited by 10 · see citing works
Optic nerve injury models under varying forces
Sun, W., Chao, G.-J., Shang, M., Wu, Q., Xia, Y.-T., Wei, Q.-P., Zhou, J., & Liao, L. (2022) · International ophtalmology · doi:10.1007/s10792-022-02476-2 · Cited by 6 · see citing works
Moghimi, S., Girkin, C. A., & Weinreb, R. N. (2025) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2025.07.008 · Cited by 6 · see citing works
Self-citationHu, H., Liu, X., Nie, D., Fang, M., Zhang, J., & Zhang, G. (2023) · Cell Biology International · doi:10.1002/cbin.12030 · Cited by 6 · see citing works
Anesthetic effects on electrophysiological responses across the visual pathway
Zhang, S., Xu, W., Liu, S., Xu, F., Chen, X., Qin, H., & Yao, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-79240-2 · Cited by 5 · see citing works
Bradley, J., O'Shea, P. J., Wrench, C., Mattsson, J., Paulin, R., Overed-Sayer, C. L., Rosenberg, L., Olsson, H., & Gianni, D. (2025) · SLAS DISCOVERY · doi:10.1016/j.slasd.2025.100223 · Cited by 5 · see citing works
Véret, D., & Brondello, J. (2020) · médecine/sciences · doi:10.1051/medsci/2020220 · Cited by 5 · see citing works
Zhang, Y., Huang, H., Zhong, H., Zhang, Y., He, S., Guo, Y., Wang, Y., Huang, P. H., Huang, S., & Zhong, Y. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.6.8 · Cited by 3 · see citing works
Aging, Cellular Senescence, and Glaucoma
Zhang, Y., Huang, S., Xie, B., & Zhong, Y. (2023) · Aging and Disease · doi:10.14336/ad.2023.0631 · Cited by 79 · see citing works
The existence of senescent cells in conjunctival epithelium from elderly individuals
Tomioka, Y., Kitazawa, K., Numa, K., Hughes, J. B., Yokoi, N., & Sotozono, C. (2024) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-023-01047-x · Cited by 3 · see citing works
Xu, K., Yu, L., Zhang, N., Dong, M., Xing, Y., & Yang, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1671438 · Cited by 2 · see citing works
Wang, X., Feng, Z., Sun, S., Zhang, J., Wang, K., Wang, Y., Zhao, Y., Zhao, B., Liu, B., Sun, M., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102983 · Cited by 2 · see citing works
Bin, X., Zhou, S., Xu, Y., Chen, S., Chen, S., Yao, W., Cao, Y., Qiu, K., & Ng, T. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412170 · Cited by 2 · see citing works
Cytokines in age-related eye diseases: pathogenesis and potential targets for innovative therapies
Zhang, T., & Liu, M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03926-1 · Cited by 2 · see citing works
Pan, Z., Zhang, J., Zuo, H., Li, C., Song, H., Yang, H., Wu, K., Zhao, M., Zhang, Z., Lai, Y., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00269 · Cited by 2 · see citing works
Dysregulation of neurovascular unit in the retina after optic nerve injury
Wu, Q., Wang, H., Liu, H. R., Zhang, L., & Wei, Q. (2026) · BMC Ophthalmology · doi:10.1186/s12886-026-04886-7 · Cited by 1 · see citing works
Wang, Q., Liang, Y., Zuo, Q., He, L., Zhang, T., Wang, Z., Zhai, J., Cao, B., Ma, S., Zhang, G., et al. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05321-z · Cited by 1 · see citing works
Saha, S., Singh, H. N., Soliman, A. T., & Rajasekaran, S. (2021) · medRxiv · doi:10.1101/2021.10.22.21265388 · Cited by 1 · see citing works
Rahman, I., Kaur, G., & Sundar, I. K. (2021) · Research Square · doi:10.21203/rs.3.rs-140689/v1
Building Compassion and Human Bridges through Research Collaborations
Graeve, O. A., de la Cadena, J. A. A. G., & López, A. S. M. (2022) · ACS Omega · doi:10.1021/acsomega.1c04916
Accelerated aging induced by stress in experimental murine ocular hypertensionPreprint
Xu, Q., Rydz, C., Huu, V. A. N., Rocha, L., Torre, C. P. L., Lee, I., Cho, W., Jabari, M., Donello, J. E., Weinreb, R. N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.01.490248
Self-citationPez cebra: modelado de senescencia en el contexto de la enfermedad y la regeneración
Carrillo-Rosas, S., Rios-Perez, A. D., & Zampedri, C. (2022) · Investigación en Discapacidad · doi:10.35366/107513
Chi, K., He, Y., Zuo, X., Lai, C., Cao, J., Ying, Y., Zhang, B., Li, R., Chen, M., Tan, X., et al. (2026) · British Journal of Ophthalmology · doi:10.1136/bjo-2025-329061
Purohit, P., Purohit, S., Meng, Y., Cho, W., Telese, F., & Skowronska‐Krawczyk, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.16.745098
Self-citationSkowronska‐Krawczyk, D. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.10.63
Self-citation
- Authors
- Rocha, L. R., Nguyen Huu, V. A., Palomino La Torre, C., Xu, Q., Jabari, M., Krawczyk, M., Weinreb, R. N., & Skowronska‐Krawczyk, D.
- Affiliations
- University of California San Diego (US)
- Shiley Eye Institute Hamilton Glaucoma Center and Viterbi Family Department of Ophthalmology University of California, San Diego CA USA
- Corresponding author
- Skowronska‐Krawczyk, Dorota
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2019-12-22
- Volume
- 19
- Issue
- 2
- Pages
- e13089-e13089
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC6996954
- OpenAlex
- W2996699344
- Cited by
- 68
- References
- 29
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 12 · 2023: 8 · 2022: 16 · 2021: 8 · 2020: 6
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Research to Prevent Blindness (Special Scholar Award)
- Glaucoma Research Foundation (Shaffer Grant)
- National Eye Institute (P30EY022589, R01EY027011)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- senolytics, retinal ganglion cells, ocular hypertension, glaucoma, dasatinib, senescence-associated secretory phenotype, chromatin remodeling, apoptosis, intraocular pressure, visual evoked potentials, optic neuropathy, transgenic mouse model
- MeSH terms
- Dasatinib, RNA-Seq, Animals, Evoked Potentials, Visual, Mice, Inbred C57BL, Mice, Transgenic, Ocular Hypertension, Retinal Ganglion Cells, Ganciclovir, Cellular Senescence, Apoptosis, Protein Kinase Inhibitors, Mice, Gene Ontology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
