DNA methylation-based estimator of telomere length
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. DNAmTL is not only an epigenetic biomarker of replicative history of cells, but a useful marker of age-related pathologies that are associated with it.
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Yang et al. and Lu et al. trained clocks on cellular features - mitotic cell division and telomere length, respectively - to develop models with specific sensitivity for these aspects of cellular ageing.
“Yang et al.62 and Lu et al.167 took a different approach and trained clocks on cellular features — mitotic cell division and telomere length, respectively — to develop models with specific sensitivity for these aspects of cellular ageing.”
From Measuring biological age using omics data (2022) · cites this paper as [167]
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- Authors
- Lu, A. T., Seeboth, A., Tsai, P.-C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., Li, Y., Harris, S. E., Corley, J., Taylor, A., Deary, I. J., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Chen, W., Li, S., Mangino, M., Bell, J. T., Wilson, J. G., Aviv, A., Marioni, R. E., Raj, K., & Horvath, S.
- Affiliations
- University of California, Los Angeles (US)
- Institute of Genetics and Cancer (GB)
- Chang Gung University (TW)
- Tulane University (US)
- Fred Hutch Cancer Center (US)
- National Institutes of Health (US)
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- University of Edinburgh (GB)
- VA Palo Alto Health Care System (US)
- Children's Minnesota (US)
- King's College London (GB)
- University of Mississippi Medical Center (US)
- Rutgers, The State University of New Jersey (US)
- Public Health England (GB)
- Corresponding author
- Horvath, Steve
- ORCID
- Lu, Ake T.
- Tsai, Pei-Chien
- Sun, Dianjianyi
- Reiner, Alex P.
- Kooperberg, Charles
- Ferrucci, Luigi
- Hou, Lifang
- Baccarelli, Andrea A.
- Li, Yun
- Harris, Sarah E.
- Corley, Janie
- Taylor, Adele
- Deary, Ian J.
- Stewart, James D.
- Whitsel, Eric A.
- Assimes, Themistocles L.
- Chen, Wei
- Li, Shengxu
- Mangino, Massimo
- Bell, Jordana T.
- Wilson, James G.
- Aviv, Abraham
- Marioni, Riccardo E.
- Horvath, Steve
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2019-08-18
- Volume
- 11
- Issue
- 16
- Pages
- 5895-5923
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC6738410
- OpenAlex
- W2969128479
- Cited by
- 440
- References
- 70
- Citations by year
- 2026: 62 · 2025: 98 · 2024: 90 · 2023: 53 · 2022: 75 · 2021: 36 · 2020: 21 · 2019: 4 · 2018: 1
- FWCI
- 23.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (FP7/2007–2013)
- National Institute for Health and Care Research (FP7/2007–2013)
- Age UK (MR/M01311/1, LBC1936)
- King's College London
- University of Edinburgh
- University of Queensland
- Centre for Cognitive Ageing and Cognitive Epidemiology
- National Institutes of Health (FP7/2007-2013, n01hc25195-41-0-1)
- Medical Research Council (MR/M01311/1)
- Biotechnology and Biological Sciences Research Council (BB/F019394/1)
- Economic and Social Research Council (ES/N000404/1, FP7/2007-2013)
- National Institute on Aging (U01AG060908)
- National Heart, Lung, and Blood Institute (N01-HC-025195)
- National Institute of General Medical Sciences (U54GM115428)
- National Institute of Environmental Health Sciences (R01ES020836)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- DNA methylation, telomere length, epigenetic biomarkers, age-related diseases
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Diet, Female, Humans, Leukocytes, Male, Middle Aged, Cohort Studies, Telomere, DNA Methylation, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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