Neonatal levels of neurotrophic factors and risk of autism spectrum disorders
Abstract
Objective: To examine levels of 3 neurotrophic factors (NTFs): Brain derived neurotrophic factor (BDNF), Neurotrophin‐4 (NT‐4), and transforming growth factor‐β (TGF‐β) in dried blood spot samples of neonates diagnosed with autism spectrum disorders (ASD) later in life and frequency‐matched controls. Method: Biologic samples were retrieved from the D anish N ewborn S creening B iobank. NTF s for 414 ASD cases and 820 controls were measured using L uminex technology. Associations were analyzed with continuous measures (T obit regression) as well as dichotomized at the lower and upper 10th percentiles cutoff points derived from the controls' distributions (logistic regression). Results: ASD cases were more likely to have BDNF levels falling in the lower 10th percentile (odds ratios [OR], 1.53 [95% confidence intervals (CI), 1.04–2.24], P‐value = 0.03). Similar pattern was seen for TGF‐β in females with ASD (OR, 2.36 [95% CI, 1.05–5.33], P‐value = 0.04). For NT‐4, however, ASD cases diagnosed with ICD‐10 only were less likely to have levels in upper 10th percentile compared with controls (OR, 0.22 [95% CI, 0.05–0.98], P‐value = 0.05). Conclusion: Results cautiously indicate decreased NTF s levels during neonatal period in ASD. This may contribute to the pathophysiology of ASD through impairments of neuroplasticity. Further research is required to confirm our results and to examine the potential therapeutic effects of NTF s in ASD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neonatal levels of BDNF are reduced in children later diagnosed with ASD compared with age-matched controls.
“Neonatal levels of BDNF , a critically important gene in neural development, neuronal connectivity, and activity-dependent synaptic plasticity [ 50 , 163 ], are reduced in children later diagnosed with ASD compared with age-matched controls [ 164 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [164]
Cites
The Danish National Hospital Register. A valuable source of data for modern health sciences.
Andersen, T. F., Madsen, M., Jørgensen, J. O. L., Mellemkjoer, L., & Olsen, J. H. (1999) · PubMed · Cited by 2,034 · see citing works
Prevalence of Autism Spectrum Disorders in a Total Population Sample
Kim, Y. S., Leventhal, B. L., Koh, Y.-J., Fombonne, E., Laska, E., Lim, E.-C., Cheon, K.-A., Kim, S.-J., Kim, Y.-K., Lee, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10101532 · Cited by 1,524 · see citing works
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works
The Epidemiology of Autism Spectrum Disorders
Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., Mandell, D. S., Miller, L. A., Pinto-Martin, J., Reaven, J., et al. (2007) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.28.021406.144007 · Cited by 1,228 · see citing works
Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., Egan, M. F., Meyer-Lindenberg, A., & Weinberger, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2680-04.2004 · Cited by 890 · see citing works
The Danish Medical Birth Registry.
Lb, K., & Olsen, J. (1998) · PubMed · Cited by 809 · see citing works
Postnatal Developmental Profile of Brain-Derived Neurotrophic Factor in Rat Brain and Platelets
Karege, F., Schwald, M., & Cisse, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00529-3 · Cited by 799 · see citing works
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works
Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi123 · Cited by 727 · see citing works
The Danish Psychiatric Central Register.
Munk‐Jørgensen, P., & Mortensen, P. B. (1997) · PubMed · Cited by 703 · see citing works
BDNF in schizophrenia, depression and corresponding animal models
Angelucci, F., Brené, S., & Mathé, A. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001637 · Cited by 548 · see citing works
Autism and Asperger syndrome: coexistence with other clinical disorders
Gillberg, C., & Billstedt, E. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.102005321.x · Cited by 505 · see citing works
Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation
Nelson, K. B., Grether, J. K., Croen, L., Dambrosia, J. M., Dickens, B. F., Jelliffe‐Pawlowski, L. L., Hansen, R. L., & Phillips, T. M. (2001) · Annals of Neurology · doi:10.1002/ana.1024 · Cited by 435 · see citing works
Autism: not an extremely rare disorder
Gillberg, C., & Wing, L. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb00984.x · Cited by 374 · see citing works
Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses
Durany, N., Michel, T. M., Zöchling, R., Boissl, K. W., Cruz-Sánchez, F., Riederer, P. F., & Thome, J. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00084-0 · Cited by 363 · see citing works
Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?
MEYER, U., FELDON, J., & DAMMANN, O. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212c196 · Cited by 357 · see citing works
The nerve growth factor family
Barde, Y. (1990) · Progress in Growth Factor Research · doi:10.1016/0955-2235(90)90021-b · Cited by 328 · see citing works
Skaper, S. D. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708783885174 · Cited by 326 · see citing works
Nickl‐Jockschat, T., Habel, U., Michel, T. M., Manning, J. H., Laird, A. R., Fox, P. T., Schneider, F. W., & Eickhoff, S. B. (2011) · Human Brain Mapping · doi:10.1002/hbm.21299 · Cited by 307 · see citing works
Betancur, C., Sakurai, T., & Buxbaum, J. D. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.04.003 · Cited by 298 · see citing works
Ashwood, P., Enstrom, A., Krakowiak, P., Hertz-Picciotto, I., Hansen, R. L., Croen, L. A., Ozonoff, S., Pessah, I. N., & de Water, J. V. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.07.006 · Cited by 271 · see citing works
Storage policies and use of the Danish Newborn Screening Biobank
Nørgaard‐Pedersen, B., & HOUGAARD, D. M. (2007) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-007-0631-x · Cited by 262 · see citing works
Self-citationConnolly, A. M., Chez, M. G., Streif, E. M., Keeling, R. M., Golumbek, P. T., Kwon, J. M., Riviello, J. J., Robinson, R., Neuman, R. J., & Deuel, R. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.004 · Cited by 262 · see citing works
Skogstrand, K., Thorsen, P., Nørgaard‐Pedersen, B., Schendel, D., Sørensen, L. C., & HOUGAARD, D. M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.052241 · Cited by 262 · see citing works
Self-citationLauritsen, M. B., Jørgensen, M., Madsen, K. M., Lemcke, S., Toft, S., Grove, J., Schendel, D. E., & Thorsen, P. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0818-0 · Cited by 239 · see citing works
Self-citationSerum neurotrophin concentrations in autism and mental retardation: a pilot study
Miyazaki, K., Narita, N., Sakuta, R., Miyahara, T., Naruse, H., Okado, N., & Narita, M. (2003) · Brain and Development · doi:10.1016/s0387-7604(03)00168-2 · Cited by 173 · see citing works
The NGF saga: From animal models of psychosocial stress to stress-related psychopathology
Cirulli, F., & Alleva, E. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.002 · Cited by 160 · see citing works
Brain‐derived neurotrophic factor and neurotrophin‐3 levels in Alzheimer's disease brains
Durany, N., Michel, T. M., Kurt, J., Cruz-Sánchez, F., Cervós‐Navarro, J., & Riederer, P. F. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00046-0 · Cited by 155 · see citing works
Katoh‐Semba, R., Wakako, R., Komori, T., Shigemi, H., Miyazaki, N., Ito, H., Kumagai, T., Tsuzuki, M., Shigemi, K., Yoshida, F., et al. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.07.002 · Cited by 155 · see citing works
Nelson, P. G., Kuddo, T., Song, E. Y., Dambrosia, J. M., Kohler, S. J., Satyanarayana, G., VanDunk, C., Grether, J. K., & Nelson, K. B. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.10.003 · Cited by 144 · see citing works
Clinical bioinformatics: a new emerging science
Wang, X., & Liotta, L. A. (2011) · Journal of Clinical Bioinformatics · doi:10.1186/2043-9113-1-1 · Cited by 133 · see citing works
Decreased serum levels of transforming growth factor-β1 in patients with autism
Okada, K., Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., Suda, S., Suzuki, K., Sugihara, G.-I., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.020 · Cited by 132 · see citing works
Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., Suzuki, K., Minabe, Y., Takei, N., Iyo, M., et al. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.018 · Cited by 131 · see citing works
Heterogeneity and Homogeneity Across the Autism Spectrum: The Role of Development
Jones, W., & Klin, A. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819f6c0d · Cited by 128 · see citing works
Abdallah, M. W., Larsen, N., Grove, J., Nørgaard‐Pedersen, B., Thorsen, P., Mortensen, E. L., & HOUGAARD, D. M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.003 · Cited by 124 · see citing works
Self-citationPsychiatric comorbidities in autism spectrum disorders: findings from a Danish Historic Birth Cohort
Abdallah, M. W., Greaves-Lord, K., Grove, J., Nørgaard-Pedersen, B., Hougaard, D. M., & Mortensen, E. L. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0220-2 · Cited by 108 · see citing works
Self-citationAdministrative registers in psychiatric research: a systematic review of validity studies
Byrne, N., Regan, C., & Howard, L. M. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00663.x · Cited by 107 · see citing works
Dealberto, M.-J. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01662.x · Cited by 101 · see citing works
Maternal supply of BDNF to mouse fetal brain through the placenta
Kodomari, I., Wada, E., Nakamura, S., & Wada, K. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.11.005 · Cited by 90 · see citing works
The role of neurotrophic factors in autism
Nickl‐Jockschat, T., & Michel, T. M. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.103 · Cited by 90 · see citing works
The incidence and prevalence of pervasive developmental disorders: a Danish population-based study
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2004) · Psychological Medicine · doi:10.1017/s0033291704002387 · Cited by 90 · see citing works
GDNF — A potential target to treat addiction
Carnicella, S., & Dorit Ron, A. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.12.001 · Cited by 84 · see citing works
Michel, T. M., Frangou, S., Camara, S., Thiemeyer, D., Jecel, J., Tatschner, T., Zoechling, R., & Grünblatt, E. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2008.06.001 · Cited by 78 · see citing works
Soeiro‐de‐Souza, M. G., Dias, V. V., Figueira, M. L., Forlenza, O. V., Gattaz, W. F., Zarate, C. A., & Machado‐Vieira, R. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01889.x · Cited by 72 · see citing works
Neurotrophic factors in obsessive-compulsive disorder
Fontenelle, L. F., Barbosa, I. G., Luna, J. V., Rocha, N. P., de Miranda, A. S., & Teixeira, A. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.03.034 · Cited by 67 · see citing works
Croen, L., Goines, P. E., Braunschweig, D., Yolken, R. H., Yoshida, C. K., Grether, J. K., FIREMAN, B. H., Kharrazi, M., Hansen, R. L., & de Water, J. V. (2008) · Autism Research · doi:10.1002/aur.14 · Cited by 66 · see citing works
Do neurotrophins regulate the feto-placental development?
Mayeur, S., Lukaszewski, M.-A., Breton, C., Storme, L., Vieau, D., & Lésage, J. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.008 · Cited by 44 · see citing works
The impact of sample storage time on estimates of association in biomarker discovery studies
Kugler, K., Hackl, W. O., Mueller, L. A. J., Fiegl, H., Graber, A., & Pfeiffer, R. M. (2011) · Journal of Clinical Bioinformatics · doi:10.1186/2043-9113-1-9 · Cited by 43 · see citing works
Circulating TGF-β1 Does Not Cross the Intact Blood-Brain Barrier
Kastin, A. J., Akerstrom, V. L., & Pan, W. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:21:1:43 · Cited by 39 · see citing works
Cytokines, chemokines and growth factors
Morán, G. A. G., Parra-Medina, R. S., Cardona, A. G., Quintero-Ronderos, P., & Garavito, É. (2013) · Cited by 31 · see citing works
Prevalence and the Controversy
Campbell, C. A., Davarya, S., Elsabbagh, M., Madden, L., & Fombonne, E. J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8065-6_3 · Cited by 21 · see citing works
Møller, A. R. (2009) · Neurological Research · doi:10.1179/174313209x383303 · Cited by 13 · see citing works
Hasselbalch, B. J., Knorr, U. B., Bennike, B., Hasselbalch, S. G., Soendergaard, M. G., & Kessing, L. V. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01831.x · Cited by 11 · see citing works
Chugani, D. C. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780195371826.003.0037 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0100-y · Cited by 987 · see citing works
Influence of maternal thyroid hormones during gestation on fetal brain development
Moog, N. K., Entringer, S., Heim, C. C., Wadhwa, P. D., Kathmann, N., & Buß, C. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.070 · Cited by 479 · see citing works
Environmental Factors in Autism
Grabrucker, A. M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00118 · Cited by 237 · see citing works
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works
Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?
Gładysz, D., Krzywdzińska, A., & Hozyasz, K. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0822-x · Cited by 130 · see citing works
Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis
Saghazadeh, A., & Rezaei, N. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-3024-x · Cited by 122 · see citing works
Pathophysiology of neonatal acute bacterial meningitis
Barichello, T., Fagundes, G. D., Generoso, J. S., Galvão-Elias, S., Simões, L. R., & Teixeira, A. L. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.059840-0 · Cited by 109 · see citing works
Qin, X., Feng, J., Cao, C. Q., Wu, H., Loh, Y. P., & Cheng, Y. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.1626 · Cited by 103 · see citing works
Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders
Bhandari, R., & Kuhad, A. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.012 · Cited by 100 · see citing works
Berbel, P. J., Navarro, D., & Román, G. C. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00146 · Cited by 85 · see citing works
Brain derived neurotrophic factor (BDNF) and autism spectrum disorders (ASD) in childhood
Bryn, V., Halvorsen, B., Ueland, T., Isaksen, J., Kolkova, K., Ravn, K., & Skjeldal, O. H. (2015) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2015.03.005 · Cited by 83 · see citing works
Zheng, Z., Zhang, L., Zhu, T., Huang, J., Qu, Y., & Mu, D. (2016) · Scientific Reports · doi:10.1038/srep31241 · Cited by 83 · see citing works
Reduced neonatal brain-derived neurotrophic factor is associated with autism spectrum disorders
Skogstrand, K., Hagen, C. M., Borbye‐Lorenzen, N., Christiansen, M., Bybjerg‐Grauholm, J., Bækvad‐Hansen, M., Werge, T. M., Børglum, A. D., Mors, O. N., Nordentoft, M., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0587-2 · Cited by 83 · see citing works
Self-citationEssential role of docosahexaenoic acid towards development of a smarter brain
Gharami, K., Das, M., & Das, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.014 · Cited by 78 · see citing works
Liu, S.-H., Shi, X., Fan, F.-C., & Cheng, Y. (2021) · Scientific Reports · doi:10.1038/s41598-020-79080-w · Cited by 75 · see citing works
Bahí, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.010 · Cited by 70 · see citing works
Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder
Barbosa, A. G., Pratesi, R., Paz, G. S. C., dos Santos, M. A. A. L., Uenishi, R. H., Nakano, E. Y., Gandolfi, L., & Pratesi, C. B. (2020) · Scientific Reports · doi:10.1038/s41598-020-74239-x · Cited by 65 · see citing works
Sultan, F. A., & Sweatt, J. D. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8289-5_6 · Cited by 58 · see citing works
Alterations of Growth Factors in Autism and Attention-Deficit/Hyperactivity Disorder
Gálvez‐Contreras, A. Y., Campos-Ordoñez, T., González-Castañeda, R. E., & González-Pérez, Ó. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00126 · Cited by 57 · see citing works
Bahí, A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.033 · Cited by 56 · see citing works
Scassellati, C., Zanardini, R., Tiberti, A., Pezzani, M., Valenti, V., Effedri, P., Filippini, E., Conte, S., Ottolini, A., Gennarelli, M., et al. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0447-1 · Cited by 53 · see citing works
Epigenetic Mechanisms in Autism Spectrum Disorder
Zhubi, A., Cook, E. H., Guidotti, A., & Grayson, D. R. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00006-8 · Cited by 51 · see citing works
7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders
Du, X., & Hill, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.021 · Cited by 47 · see citing works
T cell populations in children with autism spectrum disorder and co-morbid gastrointestinal symptoms
Rose, D. R., Yang, H. T., Careaga, M., Angkustsiri, K., de Water, J. V., & Ashwood, P. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100042 · Cited by 39 · see citing works
Zhang, Q.-B., Jiang, L., Kong, L., & Lu, Y. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.06.013 · Cited by 38 · see citing works
Segura, M., Pedreño, C., Obiols, J. E., Taurines, R., Pàmias, M., Grünblatt, E., & Gella, A. (2014) · Neurogenetics · doi:10.1007/s10048-014-0434-9 · Cited by 36 · see citing works
Fortunato, J. J., da Rosa, N., Laurentino, A. O. M., da Silva, M. G., Michalak, C., Borges, L. P., Soares, E. D. C. C., Reis, P. A., Neto, H. C. D. C. F., & Petronilho, F. C. (2016) · Nutrition · doi:10.1016/j.nut.2016.10.019 · Cited by 35 · see citing works
Altered Cytokine and BDNF Levels in Individuals with Autism Spectrum Disorders
Han, Y. M. Y., Yau, S., Chan, M. M. Y., Wong, C. K., & Chan, A. S.-Y. (2022) · Brain Sciences · doi:10.3390/brainsci12040460 · Cited by 34 · see citing works
Francis, K., Dougali, A., Sideri, K., Κroupis, C., Vasdekis, V., Dima, K., & Douzenis, A. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12872 · Cited by 33 · see citing works
Determinants of neonatal brain-derived neurotrophic factor and association with child development
Ghassabian, A., Sundaram, R., Chahal, N., McLain, A. C., Bell, E. M., Lawrence, D. A., & Yeung, E. H. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000414 · Cited by 33 · see citing works
Che, X., Hornig, M., Bresnahan, M., Stoltenberg, C., Magnus, P. M., Surén, P., Mjaaland, S., Reichborn-Kjennerud, T., Susser, E., & Lipkin, W. I. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01415-4 · Cited by 32 · see citing works
Sungur, A. Ö., Jochner, M. C. E., Harb, H., Kılıç, A., Garn, H., Schwarting, R. K. W., & Wöhr, M. (2017) · Hippocampus · doi:10.1002/hipo.22741 · Cited by 27 · see citing works
Neurotrophic Factors in Mouse Models of Autism Spectrum Disorder: Focus on BDNF and IGF-1
Reim, D., & Schmeißer, M. J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_7 · Cited by 27 · see citing works
Su, C., Liu, T., Chen, I.-T., Ou‐Yang, M., Huang, L.-T., Tsai, C., & Chen, C. (2021) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2020.12.012 · Cited by 27 · see citing works
Korzeniewski, S. J., Allred, E. N., O’Shea, T. M., Leviton, A., Kuban, K., for the ELGAN study investigators, Lee, K., McGovern, A., Gambardella, J., Ursprung, S., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0156-0 · Cited by 26 · see citing works
Oxidative stress, metabolic and mitochondrial abnormalities associated with autism spectrum disorder
Thorsen, M. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.018 · Cited by 26 · see citing works
The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview
Shen, X., Shi, S.-H., Li, H., Wang, C., Zhang, Y., Yu, H., Li, Y., & Liu, B. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1021207 · Cited by 24 · see citing works
Sungur, A. Ö., Schwarting, R. K. W., & Wöhr, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.038 · Cited by 24 · see citing works
Loxapine Add-on for Adolescents and Adults with Autism Spectrum Disorders and Irritability
Hellings, J. A., Reed, G. A., Cain, S., Zhou, X., Barth, F. X., Aman, M. G., Palaguachi, G. I., Mikhnev, D., Teng, R., Andridge, R., et al. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0003 · Cited by 23 · see citing works
Kazim, S. F., Cárdenas‐Aguayo, M. D. C., Arif, M., Blanchard, J., Fayyaz, F., Grundke, I., & Iqbal, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118627 · Cited by 23 · see citing works
Bio-collections in autism research
Reilly, J., Gallagher, L., Chen, J. L., Leader, G., & Shen, S. (2017) · Molecular Autism · doi:10.1186/s13229-017-0154-8 · Cited by 23 · see citing works
Bozkurt, H., Şimşek, Ş., & Şahin, S. (2021) · Autism Research · doi:10.1002/aur.2582 · Cited by 22 · see citing works
Irwin, J. L., Yeates, A. J., Mulhern, M. S., McSorley, E. M., Strain, J., Watson, G. E., Grzesik, K., Thurston, S. W., Love, T., Smith, T. H., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1424-y · Cited by 19 · see citing works
Circulating levels of neurotrophic factors in autism spectrum disorders.
Rodrigues, D. H., Rocha, N. P., Sousa, L. F. D. C., Barbosa, I. G., Kümmer, A., & Teixeira, A. L. (2014) · PubMed · Cited by 19 · see citing works
Association of gestational maternal hypothyroxinemia and increased autism risk
Chang, K., & Shin, J. I. (2014) · Annals of Neurology · doi:10.1002/ana.24143 · Cited by 17 · see citing works
Bennett, M. R., & Lagopoulos, J. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.02.007 · Cited by 16 · see citing works
The Ambiguous Role of Growth Factors in Autism: What Do We Really Know?
Spoto, G., Butera, A., Albertini, M. L., Consoli, C., Ceraolo, G., Nicotera, A. G., & Rosa, G. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041607 · Cited by 14 · see citing works
Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
Larios, J. A., Jausoro, I., Benitez, M.-L., Bronfman, F. C., & Marzolo, M.-P. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-108 · Cited by 12 · see citing works
Rapid Communication: Plasma Interleukin-35 in Children with Autism
Rose, D. R., & Ashwood, P. (2019) · Brain Sciences · doi:10.3390/brainsci9070152 · Cited by 12 · see citing works
Mohammadi, S., Lotfi, K., Mokhtari, E., Hajhashemy, Z., Heidari, Z., & Saneei, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-40625-4 · Cited by 12 · see citing works
Campos, J. M. B., da Costa, M. D. A., de Rezende, V. L., Costa, R. R. N., Ebs, M. F. P., Behenck, J. P., Casagrande, L. D. R., Venturini, L. M., Silveira, P. C. L., Réus, G. Z., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04491-z · Cited by 12 · see citing works
Aisa, M. C., Barbati, A., Cappuccini, B., Rosa, F., Gerli, S., Clerici, G., Kaptilnyy, V. A., Ishenko, A. I., & Renzo, G. C. D. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135459 · Cited by 11 · see citing works
Health Condition in Persons with Autism Spectrum Disorders
Trajkovski, V. (2018) · Journal for ReAttach Therapy and Developmental Diversities · doi:10.26407/2018jrtdd.1.12 · Cited by 11 · see citing works
Gümüşlü, K. E., Savlı, H., Akkoyunlu, D. S., Çine, N., Kara, B., Keskin, S. E., & Akkoyunlu, R. U. (2015) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1310-81 · Cited by 9 · see citing works
Gadd45 in Neuronal Development, Function, and Injury
Sultan, F. A., & Sawaya, B. E. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-94804-7_9 · Cited by 7 · see citing works
Zhang, T., Wang, H., Ouyang, F., Yang, H., Zhang, J., & Zhang, N. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.074 · Cited by 7 · see citing works
Liu, Y., Gao, H., Jin, S., Tu, W., & Chen, Y. (2021) · World Journal of Pediatrics · doi:10.1007/s12519-021-00415-2 · Cited by 7 · see citing works
Pakhtusova, N. A., Akmaev, V. A., & Nekrasova, O. S. (2023) · Autism and Developmental Disorders · doi:10.17759/autdd.2023210206 · Cited by 6 · see citing works
Prasad, J. D., Steenwinckel, J. V., Gunn, A. J., Bennet, L., Korzeniewski, S. J., Gressèns, P., & Dean, J. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312999 · Cited by 5 · see citing works
Autism spectrum disorders: possible implications of BDNF modulation through epigenetics
Pareja-Galeano, H., Sanchis‐Gomar, F., & Mayero, S. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12071 · Cited by 5 · see citing works
Chen, Q., Sun, Y., Pan, N., Long, Y., Cao, Y., Luo, Y., Xin, K., Chen, P., Wang, Y., Shu, M., et al. (2026) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-026-03068-6 · Cited by 4 · see citing works
Role of nutritional deficiency in the development of autism spectrum disorders
Oommen, A., & AlOmar, R. S. (2020) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20201959 · Cited by 4 · see citing works
Chen, W., Wu, Y. X., Hu, Y., Zhu, L., Wu, L., Bai, G., & Zou, C. (2024) · Current Chinese Science · doi:10.2174/0122102981280184231214092958 · Cited by 3 · see citing works
Exercise, Neuroplasticity, and Growth Factors in Adolescence
Pareja-Galeano, H., Mayero, S., & Sanchis‐Gomar, F. (2015) · Wiley eBooks · doi:10.1002/9781118840634.ch27 · Cited by 3 · see citing works
Epigenetic Mechanisms in Autism Spectrum Disorders
Mbadiwe, T., & Myers, R. M. (2014) · InTech eBooks · doi:10.5772/57195 · Cited by 2 · see citing works
The development of animal models for autism: A gene-environment approach
Ranger, P. (2016) · doi:10.26686/wgtn.17019029.v1 · Cited by 2 · see citing works
Idiopathic Autism Spectrum Disorder
Carroll, H. M., Thom, R. P., & McDougle, C. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-76269-7_1 · Cited by 1 · see citing works
Mukaetova‐Ladinska, E. B., & Perry, E. K. (2015) · Contemporary clinical neuroscience · doi:10.1007/978-1-4939-2190-4_15 · Cited by 1 · see citing works
Abdallah, M. W. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12072
Self-citationJalalian-Javadpour, M., Khaledian, M., Moradi, H., Behnoud, H., Sajjadi, M., Yekta, B. G., & Vaseghi, S. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00787-1
de Azevedo, O. G. R., de Vasconcelos, P. R. L., Rosa, P. N. S., Ciurleo, G. C. V., Warren, C. A., & Oriá, R. B. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1775104
- Authors
- Abdallah, M. W., Mortensen, E. L., Greaves‐Lord, K., Larsen, N., Bonefeld‐Jørgensen, E. C., Nørgaard‐Pedersen, B., Hougaard, D. M., & Grove, J.
- Affiliations
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Erasmus MC (NL)
- Aarhus University (DK)
- Corresponding author
- Abdallah, M. W.
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2012-10-05
- Volume
- 128
- Issue
- 1
- Pages
- 61-69
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2159680909
- Cited by
- 72
- References
- 55
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 6
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, neurotrophic factors, brain-derived neurotrophic factor, neurotrophin-4, TGF-beta, neonatal biomarkers, dried blood spots, neuroplasticity, sex differences
- MeSH terms
- Child Development Disorders, Pervasive, Denmark, Female, Humans, Infant, Newborn, Male, Nerve Growth Factors, Retrospective Studies, Risk Factors, Confidence Intervals, Odds Ratio, Case-Control Studies, Transforming Growth Factor beta, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
