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Cited by 19Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesHealth Systems, Economic Evaluations, Quality of LifeMental Health Treatment and Access

Cost‐effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder

Open access
van Apeldoorn, F. J., Stant, A. D., van Hout, W. J. P. J., Mersch, P. P. A., den Boer, J. A.·2014·Acta Psychiatrica Scandinavica
DOI 10.1111/acps.12169
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Abstract

Objective: The objective of this study was to assess the cost‐effectiveness of three empirically supported treatments for panic disorder with or without agoraphobia: cognitive behavioral therapy (CBT), pharmacotherapy using a selective serotonin reuptake inhibitor (SSRI), or the combination of both (CBT+SSRI). Method: Cost‐effectiveness was examined based on the data from a multicenter randomized controlled trial. The H amilton A nxiety R ating S cale was selected as a primary health outcome measure. Data on costs from a societal perspective (i.e., direct medical, direct non‐medical, and indirect non‐medical costs) were collected in the study sample (N = 150) throughout a 24‐month period in which patients received active treatment during the first twelve months and were seen twice for follow‐up in the next twelve months. Results: Total costs were largely influenced by costs of the interventions and productivity losses. The mean total societal costs were lower for CBT as compared to SSRI and CBT+SSRI. Costs of medication use were substantial for both SSRI and CBT+SSRI. When examining the balance between costs and health outcomes, both CBT and CBT+SSRI led to more positive outcomes than SSRI. Conclusion: Cognitive behavioral therapy is associated with the lowest societal costs. Cognitive behavioral therapy and CBT+SSRI are more cost‐effective treatments for panic disorder with or without agoraphobia as compared to SSRI only.

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Authors
van Apeldoorn, F. J., Stant, A. D., van Hout, W. J. P. J., Mersch, P. P. A., & den Boer, J. A.
Affiliations
  • University Medical Center Groningen Groningen the Netherlands
  • University Medical Center Groningen (NL)
  • University of Groningen Groningen the Netherlands
  • University of Groningen (NL)
ORCID
Stant, A. D.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2013-07-03
Volume
129
Issue
4
Pages
286-295
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/acps.12169
OpenAlex
W2119483238
Cited by
19
References
28
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 6 · 2014: 1 · 2013: 1
FWCI
3.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
panic disorder, agoraphobia, cost-effectiveness, cognitive behavioral therapy, selective serotonin reuptake inhibitors, combined psychotherapy and pharmacotherapy, social costs, productivity loss, Hamilton Anxiety Rating Scale, treatment costs
MeSH terms
Adolescent, Adult, Combined Modality Therapy, Cost-Benefit Analysis, Humans, Male, Middle Aged, Cognitive Behavioral Therapy, Panic Disorder, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Young Adult

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