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Cited by 314

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Clozapine‐induced myocarditis, a widely overlooked adverse reaction

Ronaldson, K. J., Fitzgerald, P. B., McNeil, J. J.·2015·Acta Psychiatrica Scandinavica
DOI 10.1111/acps.12416
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Abstract

Objective: We review the published cases of clozapine‐induced myocarditis and describe reasons for the higher incidence in Australia (>1%) than elsewhere (<0.1%). Method: Medline was searched to September 2014 using ‘clozapine’ as the sole term. Results: A total of around 250 cases of clozapine‐induced myocarditis have been published. Fever among patients commencing clozapine has been reported internationally, and very few of these cases were investigated for myocarditis. The time to onset of fever is consistent with its being part of a prodrome of undiagnosed myocarditis, and the risk factors are similar to those for myocarditis. In more severe cases, clozapine is discontinued, avoiding fatalities which may occur with myocarditis. Furthermore, cases of sudden death and respiratory illness may well have been undiagnosed myocarditis. The diagnosis of myocarditis is confounded by the non‐specific nature of the signs and symptoms, and it depends on appropriate investigations being conducted at the time of myocardial involvement or, for fatal cases, the affected area of the myocardium being sampled for histology. Conclusion: It is likely that the incidence of myocarditis is around 3%. Implementation of monitoring procedures will increase case ascertainment and result in more patients benefiting from this valuable medication.

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Metadata

Authors
Ronaldson, K. J., Fitzgerald, P. B., & McNeil, J. J.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2015-04-11
Volume
132
Issue
4
Pages
231-240
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/acps.12416
OpenAlex
W1979668217
Cited by
314
References
50
FWCI
10.93
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Clozapine‐induced myocarditis, a widely overlooked adverse reaction. https://app.cochat.ai/papers/10.1111/acps.12416
The paper
Ronaldson, K. J., Fitzgerald, P. B., & McNeil, J. J. (2015). Clozapine‐induced myocarditis, a widely overlooked adverse reaction. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.12416

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.