Schizophrenia, neuroleptic medication and mortality
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BACKGROUND: There is an excess of death from natural causes among people with schizophrenia. AIMS: Schizophrenia and its treatment with neuroleptics were studied for their prediction of mortality in a representative population sample of 7217 Finns aged >/= 30 years. METHOD: A comprehensive health examination was carried out at baseline. Schizophrenia was determined using the Present State Examination and previous medical records. RESULTS: During a 17-year follow-up, 39 of the 99 people with schizophrenia died. Adjusted for age and gender, the relative mortality risk between those with schizophrenia and others was 2.84 (95% CI 2.06-3.90), and was 2.25 (95% CI1.61-3.15) after further adjusting for somatic diseases, bloodpressure, cholesterol, body mass index, smoking, exercise, alcohol intake and education. The number of neuroleptics used at the time of the baseline survey showed a graded relation to mortality. Adjusted for age, gender, somatic diseases and other potential risk factors for premature death, the relative risk was 2.50 (95% CI1.46-4.30) per increment of one neuroleptic. CONCLUSIONS: There is an urgent need to ascertain whether the high mortality in schizophrenia is attributable to the disorder itself or the antipsychotic medication.
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Findings on the association between exposure to antipsychotic medication and natural-cause mortality remain inconsistent.
“overall, findings on the association between exposure to antipsychotic medication and natural-cause mortality remain inconsistent.2,48,49”
From Mortality in Schizophrenia and Other Psychoses: A 10-Year Follow-up of the ӔSOP First-Episode Cohort (2015) · cites this paper as [49]
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- Authors
- Joukamaa, M., Heliövaara, M., Knekt, P., Aromaa, A., Raitasalo, R., & Lehtinen, V.
- Affiliations
- Tampere University (FI)
- Social Insurance Institution (FI)
- Corresponding author
- Joukamaa, Matti
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2006-02
- Volume
- 188
- Issue
- 2
- Pages
- 122-127
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2150154702
- Cited by
- 395
- References
- 30
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 18 · 2020: 13 · 2019: 16 · 2018: 17 · 2017: 45 · 2016: 17 · 2015: 16 · 2014: 31 · 2013: 25 · 2012: 28
- FWCI
- 20.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, mortality, antipsychotic drugs, excess mortality, natural death, adverse drug reactions, Finnish population
- MeSH terms
- Adult, Aged, Blood Pressure, Female, Finland, Follow-Up Studies, Humans, Life Style, Cholesterol, HDL, Male, Middle Aged, Population Surveillance, Risk Factors, Schizophrenia, Smoking, Antipsychotic Agents, Exercise, Prevalence, Age Distribution, Sex Distribution, Polypharmacy
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