Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia Registry

Enache, D.; Fereshtehnejad, S.‐M.; Kåreholt, I.; Cermakova, P.; Garcia‐Ptacek, S.; Johnell, K.; Religa, D.; Jelic, V.; Winblad, B.; Ballard, C.; Aarsland, D.; Fastbom, J.; Eriksdotter, M.

doi:10.1111/acps.12630

Cited by 42Dementia and Cognitive Impairment ResearchPharmaceutical Practices and Patient OutcomesTreatment of Major Depression

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Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia Registry

Enache, D., Fereshtehnejad, S.‐M., Kåreholt, I., Cermakova, P., Garcia‐Ptacek, S., Johnell, K., Religa, D., Jelic, V., Winblad, B., Ballard, C., Aarsland, D., Fastbom, J., Eriksdotter, M.·2016·Acta Psychiatrica Scandinavica

DOI 10.1111/acps.12630

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Abstract

Background: The association between mortality risk and use of antidepressants in people with dementia is unknown. Objective: To describe the use of antidepressants in people with different dementia diagnoses and to explore mortality risk associated with use of antidepressants 3 years before a dementia diagnosis. Methods: Study population included 20 050 memory clinic patients from the Swedish Dementia Registry (SveDem) diagnosed with incident dementia. Data on antidepressants dispensed at the time of dementia diagnosis and during 3‐year period before dementia diagnosis were obtained from the Swedish Prescribed Drug Register. Cox regression models were used. Results: During a median follow‐up of 2 years from dementia diagnosis, 25.8% of dementia patients died. A quarter (25.0%) of patients were on antidepressants at the time of dementia diagnosis, while 21.6% used antidepressants at some point during a 3‐year period before a dementia diagnosis. Use of antidepressant treatment for 3 consecutive years before a dementia diagnosis was associated with a lower mortality risk for all dementia disorders and in Alzheimer's disease. Conclusion: Antidepressant treatment is common among patients with dementia. Use of antidepressants during prodromal stages may reduce mortality in dementia and specifically in Alzheimer's disease.

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Sorted by citations

Depression and Antidepressants as Potential Risk Factors in Dementia: A Systematic Review and Meta-analysis of 18 Longitudinal Studies
Chan, J. Y. C., Yiu, K. K. L., Kwok, T. C. Y., Wong, S. Y. S., & Tsoi, K. K. F. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.12.004 · Cited by 135
Antidepressant use and cognitive decline in patients with dementia: a national cohort study
Mo, M., Abzhandadze, T., Hoang, M. T., Sacuiu, S., Jurado, P. G., Pereira, J. B., Naia, L., Kele, J., Maioli, S., Xu, H., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-03851-3 · Cited by 45
Self-citation

Authors: Enache, D., Fereshtehnejad, S. ‐., Kåreholt, I., Cermakova, P., Garcia‐Ptacek, S., Johnell, K., Religa, D., Jelic, V., Winblad, B., Ballard, C., Aarsland, D., Fastbom, J., & Eriksdotter, M.
Affiliations: Karolinska University Hospital (SE)
Karolinska Institutet (SE)
Division of Neurogeriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden
Division of Clinical Geriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden
King's College London (GB)
Corresponding author: Enache, D.
ORCID: Enache, D.
Fereshtehnejad, S.‐M.
Kåreholt, I.
Johnell, K.
Religa, D.
Winblad, B.
Ballard, C.
Aarsland, D.
Fastbom, J.
Eriksdotter, M.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2016-09
Volume: 134
Issue: 5
Pages: 430-440
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/acps.12630
OpenAlex: W2515872908
Cited by: 42
References: 14
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 11 · 2018: 2 · 2017: 2
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Swedish Brain Power
Karolinska Institutet
Vetenskapsrådet
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: antidepressants, dementia, mortality risk, Alzheimer's disease, prodromal dementia, antidepressant use, memory clinic patients
MeSH terms: Aged, Aged, 80 and over, Antidepressive Agents, Dementia, Female, Humans, Male, Middle Aged, Prospective Studies, Registries, Sweden

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Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia Registry

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