Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence: Ibudilast and alcohol

Increased Ethanol Drinking After Repeated Chronic Ethanol Exposure and Withdrawal Experience in C57BL/6 Mice

Becker, H. C., & Lopez, M. F. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000149977.95306.3a · Cited by 419 · see citing works

Long‐lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol

Rimondini, R., Arlinde, C., Sommer, W. H., & Heilig, M. A. (2002) · The FASEB Journal · doi:10.1096/fj.01-0593com · Cited by 320 · see citing works

Induction of innate immune genes in brain create the neurobiology of addiction

Crews, F. T., Zou, J., & Qin, L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.03.003 · Cited by 313 · see citing works

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

Crews, F. T., Qin, L., Sheedy, D. L., Vetreno, R. P., & Zou, J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.030 · Cited by 295 · see citing works

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

Qin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-5 · Cited by 290 · see citing works

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

Blednov, Y. A., Ponomarev, I., Geil, C., Bergeson, S., Koob, G. F., & Harris, R. A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00284.x · Cited by 251 · see citing works

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

Cho, Y., Crichlow, G. V., Vermeire, J. J., Leng, L., Du, X., Hodsdon, M. E., Bucala, R., Cappello, M., Gross, M. I., Gaeta, F. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002716107 · Cited by 205 · see citing works

Medications development to treat alcohol dependence: a vision for the next decade

Litten, R. Z., Egli, M., Heilig, M. A., Cui, C., Fertig, J. B., Ryan, M. L., Falk, D. E., Moss, H. B., Huebner, R. B., & Noronha, A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00454.x · Cited by 204 · see citing works

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease

Rolan, P. E., Hutchinson, M. R., & Johnson, K. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903426189 · Cited by 160 · see citing works

Ibudilast (AV-411)

Ledeboer, A., Hutchinson, M. R., Watkins, L. R., & Johnson, K. W. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.7.935 · Cited by 153 · see citing works

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

Gibson, L. C. D., Hastings, S. F., McPhee, I., Clayton, R. A., Darroch, C. E., MacKenzie, A., MacKenzie, F. L., Nagasawa, M., Stevens, P. A., & MacKenzie, S. J. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.02.053 · Cited by 148 · see citing works

Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens

Griffin, W. C., Lopez, M. F., Yanke, A. B., Middaugh, L. D., & Becker, H. C. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1324-3 · Cited by 136 · see citing works

Society for the Study of Addiction

Rathod, N. H. (1977) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a044048 · Cited by 121 · see citing works

Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues

Heilig, M., Thorsell, A., Sommer, W. H., Hansson, A. C., Ramchandani, V. A., George, D. T., Hommer, D., & Barr, C. S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.018 · Cited by 117 · see citing works

Stress- and Glucocorticoid-Induced Priming of Neuroinflammatory Responses: Potential Mechanisms of Stress-Induced Vulnerability to Drugs of Abuse

Frank, M. G., Watkins, L. R., & Maier, S. F. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.01.005 · Cited by 116 · cited 1× · see citing works

Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism?

Egli, M. (2005) · Addiction Biology · doi:10.1080/13556210500314550 · Cited by 86 · see citing works

Inhibition of phosphodiesterase-4 decreases ethanol intake in mice

Hu, W., Lu, T., Chen, A., Huang, Y., Hansen, R., Chandler, L. J., & Zhang, H. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2290-8 · Cited by 77 · see citing works

Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat

Wakita, H., Tomimoto, H., Akiguchi, I., Lin, J.-X., Ihara, M., Ohtani, R., & Shibata, M. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.028 · Cited by 74 · see citing works

The Phosphodiesterase‐4 ( PDE 4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol‐Preferring Fawn‐Hooded Rats

Wen, R., Zhang, M., Qin, W., Liu, Q., Wang, W., Lawrence, A. J., Zhang, H., & Liang, J. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01845.x · Cited by 71 · see citing works

Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses

Rolan, P. E., Gibbons, J. A., He, L., Chang, E., Jones, D., Gross, M. I., Davidson, J. B., Sanftner, L. M., & Johnson, K. W. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2008.03270.x · Cited by 70 · see citing works

A small‐molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease

Kithcart, A. P., Cox, G. M., Sielecki, T. M., Short, A., Pruitt, J. R., Papenfuss, T. L., Shawler, T. M., Gienapp, I. E., Satoskar, A. R., & Whitacre, C. C. (2010) · The FASEB Journal · doi:10.1096/fj.10-162347 · Cited by 48 · see citing works

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works

Effect of alcohol use on the adolescent brain and behavior

Lees, B., Meredith, L. R., Kirkland, A. E., Bryant, B. E., & Squeglia, L. M. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172906 · Cited by 411 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

The role of neuroimmune signaling in alcoholism

Crews, F. T., Lawrimore, C. J., Walter, T. J., & Coleman, L. G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.031 · Cited by 321 · see citing works

Mechanisms of neuroimmune gene induction in alcoholism

Crews, F. T., & Vetreno, R. P. (2016) · Psychopharmacology · doi:10.1007/s00213-015-3906-1 · Cited by 232 · see citing works

Neuroimmune signaling in alcohol use disorder

Erickson, E. K., Grantham, E. K., Warden, A. S., & Harris, R. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.007 · Cited by 224 · see citing works

Astrocytic Dysfunction and Addiction

Scofield, M. D., & Kalivas, P. W. (2014) · The Neuroscientist · doi:10.1177/1073858413520347 · Cited by 193 · see citing works

Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

Montesinos, J., Alfonso‐Loeches, S., & Guerri, C. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13208 · Cited by 184 · see citing works

Molecular mechanisms underlying alcohol-drinking behaviours

Ron, D., & Barak, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.85 · Cited by 165 · see citing works

Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder

Burnette, E. M., Nieto, S. J., Grodin, E. N., Meredith, L. R., Hurley, B., Miotto, K., Gillis, A. J., & Ray, L. A. (2022) · Drugs · doi:10.1007/s40265-021-01670-3 · Cited by 169 · see citing works

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies

Kohno, M., Link, J., Dennis, L. E., McCready, H. D., Huckans, M. S., Hoffman, W. F., & Loftis, J. M. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.01.007 · Cited by 168 · see citing works

Neuroimmune Mechanisms of Alcohol and Drug Addiction

Cui, C., Shurtleff, D., & Harris, R. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00001-4 · Cited by 163 · see citing works

Glutamatergic transmission in drug reward: implications for drug addiction

D’Souza, M. S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00404 · Cited by 141 · see citing works

Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial

Ray, L. A., Bujarski, S., Shoptaw, S., Roche, D. J., Heinzerling, K., & Miotto, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.10 · Cited by 118 · see citing works

Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules

Berríos‐Cárcamo, P., Quezada, M., Quintanilla, M. E., Morales, P., Ezquer, M., Herrera‐Marschitz, M., Israel, Y., & Ezquer, F. E. (2020) · Antioxidants · doi:10.3390/antiox9090830 · Cited by 108 · see citing works

Glial and neuroinflammatory targets for treating substance use disorders

Bachtell, R. K., Jones, J. D., Heinzerling, K. G., Beardsley, P. M., & Comer, S. D. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.08.003 · Cited by 104 · see citing works

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4

Bachtell, R. K., Hutchinson, M. R., Wang, X., Rice, K. C., Maier, S. F., & Watkins, L. R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150529132503 · Cited by 98 · see citing works

Medications for alcohol use disorders: An overview

Akbar, M. D., Egli, M., Cho, Y., Song, B., & Noronha, A. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.11.007 · Cited by 97 · see citing works

Innate Immune Signaling and Alcohol Use Disorders

Coleman, L. G., & Crews, F. T. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_92 · Cited by 90 · see citing works

Rat animal models for screening medications to treat alcohol use disorders

Bell, R. L., Hauser, S. R., Liang, T., Sari, Y., Maldonado‐Devincci, A. M., & Rodd, Z. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.004 · Cited by 90 · see citing works

Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial

Grodin, E. N., Bujarski, S., Towns, B., Burnette, E. M., Nieto, S. J., Lim, A. C., Lin, J. W., Miotto, K. A., Gillis, A. J., Irwin, M. R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01478-5 · Cited by 79 · see citing works

Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities

Namba, M. D., Leyrer-Jackson, J. M., Nagy, E. K., Olive, M. F., & Neisewander, J. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.650785 · Cited by 76 · see citing works

Blood Biomarkers of Alcohol Use: A Scoping Review

Harris, J. C., Leggio, L., & Farokhnia, M. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00402-7 · Cited by 77 · see citing works

Potential of Glial Cell Modulators in the Management of Substance Use Disorders

Jones, J. D. (2020) · CNS Drugs · doi:10.1007/s40263-020-00721-9 · Cited by 78 · see citing works

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Blednov, Y. A., Benavidez, J. M., Black, M., & Harris, R. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00129 · Cited by 75 · see citing works

IL-1 receptor signaling in the basolateral amygdala modulates binge-like ethanol consumption in male C57BL/6J mice

Marshall, S. A., Casachahua, J., Rinker, J. A., Blose, A. K., Lysle, D. T., & Thiele, T. E. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.006 · Cited by 73 · see citing works

Discovery, Development, and Adoption of Medications to Treat Alcohol Use Disorder: Goals for the Phases of Medications Development

Litten, R. Z., Falk, D. E., Ryan, M. L., & Fertig, J. B. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13093 · Cited by 70 · see citing works

Preclinical and clinical evidence for suppression of alcohol intake by apremilast

Grigsby, K. B., Mangieri, R. A., Roberts, A. J., Lopez, M. F., Firsick, E. J., Townsley, K. G., Beneze, A., Bess, J., Eisenstein, T. K., Meissler, J. J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci159103 · Cited by 64 · see citing works

Ethanol and Cytokines in the Central Nervous System

Roberto, M., Patel, R. R., & Bajo, M. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_77 · Cited by 71 · see citing works

Glial mechanisms underlying substance use disorders

Linker, K. E., Cross, S. J., & Leslie, F. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14163 · Cited by 64 · see citing works

Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models

Yardley, M. M., & Ray, L. A. (2016) · Addiction Biology · doi:10.1111/adb.12349 · Cited by 60 · see citing works

A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue

Elsayed, M., & Magistretti, P. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00468 · Cited by 59 · see citing works

Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study

Worley, M. J., Heinzerling, K. G., Roche, D. J. O., & SHOPTAW, S. J. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.02.036 · Cited by 57 · see citing works

Immune treatments for alcohol use disorder: A translational framework

Meredith, L. R., Burnette, E. M., Grodin, E. N., Irwin, M. R., & Ray, L. A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.023 · Cited by 60 · see citing works

Phosphodiesterase regulation of alcohol drinking in rodents

Logrip, M. L. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.03.007 · Cited by 53 · see citing works

Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer’s Disease

León, B. E., Kang, S., Franca-Solomon, G., Shang, P., & Choi, D. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.778456 · Cited by 52 · see citing works

Probiotics-Based Treatment as an Integral Approach for Alcohol Use Disorder in Alcoholic Liver Disease

Fuenzalida, C., Dufeu, M. S., Poníachik, J., Roblero, J. P., Valenzuela-Pérez, L., & Beltrán, C. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.729950 · Cited by 48 · see citing works

Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents

Gong, M., Wen, R.-T., Xu, Y., Pan, J., Fei, N., Yan-meng, Z., Xu, J., Liang, J., & Zhang, H. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4697-3 · Cited by 48 · see citing works

The future of translational research on alcohol use disorder

Ray, L. A., Grodin, E. N., Leggio, L., Bechtholt, A. J., Becker, H. C., Ewing, S. W. F., Jentsch, D., King, A. C., Mason, B. J., O’Malley, S. S., et al. (2020) · Addiction Biology · doi:10.1111/adb.12903 · Cited by 47 · see citing works

Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4)

Franklin, K. M., Hauser, S. R., Lasek, A. W., McClintick, J., Ding, Z.-M., McBride, W. J., & Bell, R. L. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3852-3 · Cited by 44 · see citing works

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

Bell, R. L., Hauser, S. R., Rodd, Z. A., Liang, T., Sari, Y., McClintick, J. N., Rahman, S., & Engleman, E. A. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.02.017 · Cited by 45 · see citing works

Modulation of Binge-like Ethanol Consumption by IL-10 Signaling in the Basolateral Amygdala

Marshall, S. A., McKnight, K. H., Blose, A. K., Lysle, D. T., & Thiele, T. E. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9709-2 · Cited by 41 · see citing works

Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders

Melbourne, J. K., Thompson, K. R., Peng, H., & Nixon, K. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.011 · Cited by 40 · see citing works

Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation

Israel, Y., Quintanilla, M. E., Ezquer, F. E., Morales, P., Santapau, D., Berríos‐Cárcamo, P., Ezquer, M., Olivares, B., & Herrera‐Marschitz, M. (2019) · Addiction Biology · doi:10.1111/adb.12853 · Cited by 41 · see citing works

Sex-dependent factors of alcohol and neuroimmune mechanisms

Cruz, B., Borgonetti, V., Bajo, M., & Roberto, M. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100562 · Cited by 37 · see citing works

Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol-Drinking Behavior in Alcohol-Dependent Mice

Bajo, M., Montgomery, S. E., Cates, L. N., Nadav, T., Delucchi, A. M., Cheng, K., Yin, H., Crawford, E. F., Roberts, A. J., & Roberto, M. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw026 · Cited by 37 · see citing works

Low Vs. High Alcohol: Central Benefits Vs. Detriments

Tizabi, Y., Getachew, B., Ferguson, C. L., Csoka, A. B., Thompson, K. M., Gómez-Paz, A., Kučerová, J., & Taylor, R. E. (2018) · Neurotoxicity Research · doi:10.1007/s12640-017-9859-x · Cited by 35 · see citing works

Ibudilast attenuates doxorubicin‐induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga‐Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Matsunaga, N., Koyanagi, S., Azuma, Y., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14777 · Cited by 35 · see citing works

Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options

Quintanilla, M. E., Ezquer, F. E., Morales, P., Santapau, D., Berríos‐Cárcamo, P., Ezquer, M., Herrera‐Marschitz, M., & Israel, Y. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1304-z · Cited by 36 · see citing works

Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review

Fischler, P. V., Soyka, M., Seifritz, E., & Mutschler, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927703 · Cited by 34 · see citing works

An Animal Model of Alcohol Dependence to Screen Medications for Treating Alcoholism

Becker, H. C., & Lopez, M. F. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.02.006 · Cited by 32 · see citing works

Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference

Blednov, Y. A., Costa, A. J. D., Tarbox, T., Ponomareva, O. Y., Messing, R. O., & Harris, R. A. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13616 · Cited by 35 · see citing works

Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F‐DPA‐714

Saba, W., Goutal, S., Auvity, S., Kühnast, B., Coulon, C., Kouyoumdjian, V., Buvat, I., Leroy, C., & Tournier, N. (2017) · Addiction Biology · doi:10.1111/adb.12548 · Cited by 34 · see citing works

Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse‐like drinking in high‐alcohol drinker rats

Ezquer, F. E., Quintanilla, M. E., Morales, P., Ezquer, M., Lespay‐Rebolledo, C., Herrera‐Marschitz, M., & Israel, Y. (2017) · Addiction Biology · doi:10.1111/adb.12572 · Cited by 33 · see citing works

The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice

Liu, X. B., Hao, P., Yang, M., Sun, J., Mao, L., Fan, C., Zhang, Z., Li, D.-W., Yang, X., Sun, B., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4631-8 · Cited by 32 · see citing works

Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism

Ibáñez, C., Acuña, T., Quintanilla, M. E., Pérez-Reytor, D., Morales, P., & Karahanian, E. (2023) · Antioxidants · doi:10.3390/antiox12091758 · Cited by 32 · see citing works

Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy

Jacobsen, J. H. W., Hutchinson, M. R., & Mustafa, S. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.010 · Cited by 32 · see citing works

Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies

Leggio, L., Falk, D. E., Ryan, M. L., Fertig, J. B., & Litten, R. Z. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_295 · Cited by 32 · see citing works

Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder

Wen, R.-T., Zhang, F.-F., & Zhang, H. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4895-7 · Cited by 31 · see citing works

Ibudilast attenuates alcohol cue–elicited frontostriatal functional connectivity in alcohol use disorder

Burnette, E. M., Ray, L. A., Irwin, M. R., & Grodin, E. N. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14696 · Cited by 32 · see citing works

Ibudilast for the treatment of drug addiction and other neurological conditions

Johnson, K. W., Matsuda, K., & Iwaki, Y. (2014) · Clinical Investigation · doi:10.4155/cli.14.8 · Cited by 29 · see citing works

Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities

Olsen, C. M., & Liu, Q.-S. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1424-0 · Cited by 29 · see citing works

Alcohol, HMGB1, and Innate Immune Signaling in the Brain

Crews, F. T. (2024) · Alcohol research · doi:10.35946/arcr.v44.1.04 · Cited by 28 · see citing works

Advances in Pharmacotherapy Development: Human Clinical Studies

Litten, R. Z., Falk, D. E., Ryan, M. L., Fertig, J. B., & Leggio, L. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_79 · Cited by 29 · see citing works

Novel medications for problematic alcohol use

Heilig, M. A., Witkiewitz, K. A., Ray, L. A., & Leggio, L. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172889 · Cited by 27 · see citing works

Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats

Poland, R. S., Hahn, Y. K., Knapp, P. E., Beardsley, P. M., & Bowers, M. S. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.06.024 · Cited by 27 · see citing works

Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial

Grodin, E. N., Nieto, S. J., Meredith, L. R., Burnette, E., O'Neill, J., Alger, J., London, E. D., Miotto, K., Evans, C. J., Irwin, M. R., et al. (2022) · Addiction Biology · doi:10.1111/adb.13182 · Cited by 25 · see citing works

The Neuroimmune Transcriptome and Alcohol Dependence: Potential for Targeted Therapies

Warden, A. S., Erickson, E. K., Robinson, G., Harris, R. A., & Mayfield, R. D. (2016) · Pharmacogenomics · doi:10.2217/pgs-2016-0062 · Cited by 26 · see citing works

Tigecycline Reduces Ethanol Intake in Dependent and Nondependent Male and Female C57 BL /6J Mice

Bergeson, S. E., Nipper, M. A., Jensen, J. P., Helms, M. L., & Finn, D. A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13251 · Cited by 25 · see citing works

Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

Woodcock, E. A., Hillmer, A. T., Mason, G. F., & Cosgrove, K. (2019) · Complex Psychiatry · doi:10.1159/000499621 · Cited by 25 · see citing works

Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders

Smiley, C. E., & Wood, S. K. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108212 · Cited by 23 · see citing works

Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains

Chavez, C. L. J., Bryant, C. D., Munn‐Chernoff, M. A., & Szumlinski, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115443 · Cited by 22 · see citing works

Imaging neuroinflammation in individuals with substance use disorders

Li, X., Ramos-Rolón, A. P., Kass, G., Pereira-Rufino, L. D. S., Shifman, N., Shi, Z., Volkow, N. D., & Wiers, C. E. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172884 · Cited by 20 · see citing works

Ibudilast may improve attention during early abstinence from methamphetamine

Birath, J. B., Briones, M., Amaya, S., Shoptaw, S., Swanson, A.-N., Tsuang, J., Furst, B., Heinzerling, K., Obermeit, L., Maes, L., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.05.016 · Cited by 19 · see citing works

Neuroimaging of inflammation in alcohol use disorder: a review

Feldman, D. E., McPherson, K. L., Biesecker, C. L., Wiers, C. E., Manza, P., Volkow, N. D., & Wang, G. (2020) · Science China Information Sciences · doi:10.1007/s11432-019-2857-5 · Cited by 19 · see citing works

The Significance of Toll-Like Receptors in the Neuroimmunologic Background of Alcohol Dependence

Czerwińska-Błaszczyk, A., Pawlak, E., & Pawłowski, T. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.797123 · Cited by 19 · see citing works

Baseline C-reactive protein levels are predictive of treatment response to a neuroimmune modulator in individuals with an alcohol use disorder: a preliminary study

Grodin, E. N., Meredith, L. R., Burnette, E. M., Miotto, K. A., Irwin, M. R., & Ray, L. A. (2022) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2022.2124918 · Cited by 19 · see citing works

Transcriptome Analysis of Alcohol Drinking in Non-Dependent and Dependent Mice Following Repeated Cycles of Forced Swim Stress Exposure

Farris, S. P., Tiwari, G. R., Ponomareva, O. Y., Lopez, M. F., Mayfield, R. D., & Becker, H. C. (2020) · Brain Sciences · doi:10.3390/brainsci10050275 · Cited by 19 · see citing works

Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats

Mu, L., Liu, X., Yu, H., Hu, M.-M., Friedman, V., Kelly, T. J., Zhao, L., & Liu, Q.-S. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108830 · Cited by 19 · see citing works

Advancing Pharmacotherapy Development from Preclinical Animal Studies

Egli, M. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2017_85 · Cited by 19 · see citing works

From gene networks to drugs: systems pharmacology approaches for AUD

Ferguson, L. B., Harris, R. A., & Mayfield, R. D. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4855-2 · Cited by 19 · see citing works

Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review

Karimi‐Haghighi, S., Chavoshinezhad, S., Mozafari, R., Noorbakhsh, F., Borhani‐Haghighi, A., & Haghparast, A. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01223-6 · Cited by 19 · see citing works

A Neuroimmune Modulator for Alcohol Use Disorder

Ray, L. A., Meredith, L. R., Grodin, E. N., Belnap, M. A., Nieto, S. J., Baskerville, W., Donato, S., SHOPTAW, S. J., Gillis, A. J., Irwin, M. R., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.7523 · Cited by 17 · see citing works

Neurochemical Evidence of Preclinical and Clinical Reports on Target-Based Therapy in Alcohol Used Disorder

Prajapati, S. K., Bhaseen, S., Krishnamurthy, S., & Sahu, A. N. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02944-9 · Cited by 17 · see citing works

Role of Phosphodiesterase 4-Mediated Cyclic AMP Signaling in Pharmacotherapy for Substance Dependence

Wen, R.-T., Feng, W., Liang, J.-H., & Zhang, H. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140826114412 · Cited by 17 · see citing works

Evaluation of childhood traumatic experience as a risk factor for alcohol use disorder in adulthood

Wang, L., An, C., Song, M., Li, N., Gao, Y., Zhao, X., Yu, L., Wang, Y., & Wang, X. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-2428-5 · Cited by 18 · see citing works

Ibudilast for alcohol use disorder: study protocol for a phase II randomized clinical trial

Burnette, E. M., Baskerville, W., Grodin, E. N., & Ray, L. A. (2020) · Trials · doi:10.1186/s13063-020-04670-y · Cited by 15 · see citing works

Acute Ethanol Challenge Differentially Regulates Expression of Growth Factors and miRNA Expression Profile of Whole Tissue of the Dorsal Hippocampus

Barney, T. M., Vore, A. S., & Deak, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.884197 · Cited by 10 · see citing works

Activation of Melanocortin-4 Receptor Inhibits Both Neuroinflammation Induced by Early Exposure to Ethanol and Subsequent Voluntary Alcohol Intake in Adulthood in Animal Models: Is BDNF the Key Mediator?

Flores-Bastías, O., Adriasola-Carrasco, A. A., & Karahanian, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00005 · Cited by 14 · see citing works

Astrocytes promote ethanol-induced enhancement of intracellular Ca2+ signals through intercellular communication with neurons

Kim, H.-B., Morris, J. F., Miyashiro, K., Lehto, T., Langel, Ü., Eberwine, J. H., & Sul, J. (2021) · iScience · doi:10.1016/j.isci.2021.102436 · Cited by 14 · see citing works

Investigational drugs for alcohol use disorders: a review of preclinical data

Ch’ng, S. S., & Lawrence, A. J. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1472763 · Cited by 14 · see citing works

Alcohol use disorder, neuroinflammation, and intake of dietary fibers: a new approach for treatment

Pérez-Reytor, D., & Karahanian, E. (2022) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2022.2114005 · Cited by 13 · see citing works

The effect of neuroimmune modulation on subjective response to alcohol in the natural environment

Meredith, L. R., Grodin, E. N., Montoya, A. K., Miranda, R., Squeglia, L. M., Towns, B., Evans, C., & Ray, L. A. (2022) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14821 · Cited by 12 · see citing works

Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats

Minnig, M. A., Blasio, A., Ferragud, A., Sami, Y. N., Erhard, E. E., Clark, R. H., DiLeo, A., Giuliano, C., Everitt, B. J., Cottone, P., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109063 · Cited by 11 · see citing works

Selective Inhibition of PDE4B Reduces Methamphetamine Reinforcement in Two C57BL/6 Substrains

Honeywell, K. M., Doren, E. V., & Szumlinski, K. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094872 · Cited by 12 · see citing works

Long-term drinking stability in the open-access self-administration monkey model

Baker, E. J., Moore, S., Gonzales, S. W., & Grant, K. A. (2023) · Alcohol · doi:10.1016/j.alcohol.2023.07.002 · Cited by 11 · see citing works

Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification

Huang, M., Chung, R., Lin, P., Kuo, H., Liu, T., Chen, Y.-Y., Chen, A. C. H., & Liu, Y. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.016 · Cited by 10 · see citing works

Acute and Chronic Ethanol Effects during Adolescence on Neuroimmune Responses: Consequences and Potential Pharmacologic Interventions

Nwachukwu, K. N., Mohammed, H. E., Mebane, D. R., Barber, A. W., Swartzwelder, H. S., & Marshall, S. A. (2023) · Cells · doi:10.3390/cells12101423 · Cited by 9 · see citing works

Apremilast reduces co-occurring alcohol drinking and mechanical allodynia and regulates central amygdala GABAergic transmission

Vozella, V., Borgonetti, V., Cruz, B., Onge, C. M. S., Bullard, R., Vlkolinský, R., Ceballos, D. G., Ozburn, A. R., Roberts, A. J., Ciccocioppo, R., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.189732 · Cited by 11 · see citing works

Promising immunomodulators for management of substance and alcohol use disorders

Acuña, A. M., Park, C., Leyrer‐Jackson, J. M., & Olive, M. F. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2360653 · Cited by 8 · see citing works

Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial

Grodin, E. N., Bujarski, S., Towns, B., Burnette, E. M., Nieto, S. J., Lim, A. C., Lin, J. W., Miotto, K. A., Gillis, A. J., Irwin, M. R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01478-5 · Cited by 79 · see citing works

Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial

Grodin, E. N., Nieto, S. J., Meredith, L. R., Burnette, E., O'Neill, J., Alger, J., London, E. D., Miotto, K., Evans, C. J., Irwin, M. R., et al. (2022) · Addiction Biology · doi:10.1111/adb.13182 · Cited by 25 · see citing works

Development of the Neuroimmune Modulator Ibudilast for the Treatment of Alcoholism: A Randomized, Placebo-Controlled, Human Laboratory Trial

Ray, L. A., Bujarski, S., Shoptaw, S., Roche, D. J., Heinzerling, K., & Miotto, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.10 · Cited by 118 · see citing works

A Neuroimmune Modulator for Alcohol Use Disorder

Ray, L. A., Meredith, L. R., Grodin, E. N., Belnap, M. A., Nieto, S. J., Baskerville, W., Donato, S., SHOPTAW, S. J., Gillis, A. J., Irwin, M. R., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.7523 · Cited by 17 · see citing works

Preclinical and clinical evidence for suppression of alcohol intake by apremilast

Grigsby, K. B., Mangieri, R. A., Roberts, A. J., Lopez, M. F., Firsick, E. J., Townsley, K. G., Beneze, A., Bess, J., Eisenstein, T. K., Meissler, J. J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci159103 · Cited by 64 · see citing works