Alcohol Attributable Fraction for Injury Morbidity from the Dose‐Response Relationship of Acute Alcohol Consumption: Emergency Department Data from 18 Countries
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Aims: To calculate the alcohol‐attributable fraction (AAF) of injury morbidity by volume of consumption prior to injury based on newly reported relative risk (RR) estimates. Design: AAF estimates based on the dose‐response RR estimates obtained from previous pair‐matched case‐crossover fractional polynomial analysis of mean volume in volume categories were calculated from the prevalence of drinking prior to injury in each volume category. Setting: Thirty‐seven emergency departments (EDs) across 18 countries. Participants: Probability samples of patients, with equal representation of each shift for each day of the week, totaling 14,026 who arrived at the ED within six hours of injury from ED studies conducted between 2001 and 2011. Measurements: AAF was analyzed by gender, age (18‐30; >30), cause of injury (traffic, assault, fall, other), and country detrimental drinking pattern (DDP). Findings: For the EDs analyzed, 16.4% of all injuries were estimated to be attributable to alcohol, and the AAF did not vary by age but was over twice as large for males (20.6%; 19.3‐21.8) than for females (8.6%; 7.5‐9.7%). While females were at greater risk of injury than males at higher volume levels, lower prevalence of women drinking at higher levels contributed to overall lower AAF for women. Assault‐related injuries showed the largest AAF (44.1%; 37.6‐42.6). AAF was slightly higher for injuries from falls (14.3%; 12.9‐15.7) than motor vehicle crashes (11.1%; 9.3‐12.9). AAF was higher in those countries with a DDP of 3 (18.6; 17.5‐19.7) and 4 (19.4%; 17.3‐21.6) than those with a DDP of 2 (12.0%; 10.5‐13.5). Conclusions: Alcohol‐attributable injuries presenting in emergency departments are higher for males than females, for violence‐related injuries compared with other types of injury, and for countries with more detrimental drinking patterns compared with those with less detrimental patterns.
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The dose-response relationship between acute alcohol use, measured through the blood alcohol concentration and injury, seems exponential for all injury types, albeit varying slightly by type of injury.
“The dose–response relationship between acute alcohol use, measured through the blood alcohol concentration and injury, seem exponential for all injury types, albeit varying slightly by type of injury 311, 312, 313.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [311]
Drinking of the victim impacts upon the risk and severity of violent acts.
“drinking of the victim 311, 340, 341 and drinking of the perpetrator seem to impact upon the risk and severity of violent acts 340, 342”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [311]
The biggest difference in risk relations will probably be found in injury outcomes, as these depend more upon environment than disease.
“The biggest difference in risk relations will probably be found in injury outcomes, as these depend more upon environment than disease 311, 344.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [311]
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The relationship between different dimensions of alcohol use and the burden of disease—an update
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- Authors
- Cherpitel, C. J., Ye, Y., Bond, J., Borges, G., Monteiro, M., Chou, P., & Hao, W.
- Affiliations
- Alcohol Research Group (US)
- Universidad Autónoma Metropolitana (MX)
- World Health Organization Regional Office for the Americas (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Hunan Medical University Changsa China
- Corresponding author
- Cherpitel, Cheryl J.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2015-07-27
- Volume
- 110
- Issue
- 11
- Pages
- 1724-1732
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- PMC
- PMC4609233
- OpenAlex
- W1490728498
- Cited by
- 50
- References
- 33
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 2 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 2
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 2 AA013750)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Injury Epidemiology and Prevention
- Keywords
- alcohol-attributable fraction, trauma morbidity, acute alcohol consumption, dose-response relationship, emergency department patients, assault injuries, road traffic injuries, falls, sex differences, alcohol consumption volume
- MeSH terms
- Accidental Falls, Accidents, Traffic, Adolescent, Adult, Alcohol Drinking, Alcoholic Intoxication, Emergency Service, Hospital, Female, Humans, Male, Risk, Risk Factors, Sex Factors, Violence, Wounds and Injuries, Prevalence, Young Adult
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