A narrative review of alcohol consumption as a risk factor for global burden of disease
Open accessAbstract
Since the original Comparative Risk Assessment (CRA) for alcohol consumption as part of the Global Burden of Disease Study for 1990, there had been regular updates of CRAs for alcohol from the World Health Organization and/or the Institute for Health Metrics and Evaluation. These studies have become more and more refined with respect to establishing causality between dimensions of alcohol consumption and different disease and mortality (cause of death) outcomes, refining risk relations, and improving the methodology for estimating exposure and alcohol-attributable burden. The present review will give an overview on the main results of the CRAs with respect to alcohol consumption as a risk factor, sketch out new trends and developments, and draw implications for future research and policy.
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Alcohol use is a major contributor to injuries, mortality and the burden of disease.
“Alcohol use is a major contributor to injuries, mortality and the burden of disease.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [1]
Alcohol use is an important cause of chronic disease and injury and is one of the top 5 risk factors for death and disability worldwide.
“Alcohol use is an important cause of chronic disease and injury. It is one of the top 5 risk factors for death and disability in the world [1–3].”
From Patient-level interventions to reduce alcohol-related harms in low- and middle-income countries: A systematic review and meta-summary (2022) · cites this paper as [3]
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Alcohol consumption as a risk factor for atrial fibrillation: a systematic review and meta-analysis
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Self-citationRehm, J., Kehoe, T., Gmel, G., Stinson, F., Grant, B., & Gmel, G. (2010) · Population Health Metrics · doi:10.1186/1478-7954-8-3 · Cited by 207 · see citing works
Self-citationAlcohol Use and Breast Cancer: A Critical Review
Shield, K. D., Soerjomataram, I., & Rehm, J. (2016) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13071 · Cited by 204 · cited 4× · see citing works
“The quantification for the different levels of alcohol-attributable risk for breast cancer had been quite similar over the years [85], as they had been for cancer in general (e.”
BackgroundInfluentialSelf-citationBurden of Disease Associated with Alcohol Use Disorders in the United States
Rehm, J. T., Dawson, D. A., Frick, U., Gmel, G. E., Roerecke, M., Shield, K. D., & Grant, B. F. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12331 · Cited by 201 · cited 1× · see citing works
“This eliminates most categories, which are 100 % alcohol-attributable by definition, except for alcohol use disorders and fetal alcohol syndrome (for some background on burden attached for alcohol use disorders: [39, 40]; for fetal alcohol syndrome [41]), as well as smaller partially attributable categories of disease…”
BackgroundSelf-citationSamokhvalov, A. V., Rehm, J., & Roerecke, M. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.023 · Cited by 200 · cited 2× · see citing works
“For alcoholinduced chronic pancreatitis, the CRA has to rely on the larger category of pancreatitis and meta-analyses on the impact of alcohol on this category [37, 38] to be included into alcohol-attributable deaths or burden of disease.”
BackgroundSelf-citationAlcohol consumption, unprovoked seizures, and epilepsy: A systematic review and meta‐analysis
Samokhvalov, A. V., Irving, H., Mohapatra, S., & Rehm, J. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02426.x · Cited by 198 · cited 1× · see citing works
“Other categories of alcohol-attributable disease and mortality included in current CRAs are fetal alcohol syndrome (by definition), epilepsy [69], gastrointestinal disease (liver cirrhosis [70] and pancreatitis [37, 38]; the latter new for the CRA associated with GBD study 2010 and after), diabetes [71], cardiovascula…”
BackgroundSelf-citationIs There a Causal Relationship between Alcohol Use and Violence?
Lipsey, M. W., Wilson, D. B., Cohen, M. A., & Derzon, J. H. (2002) · Recent Developments in Alcoholism · doi:10.1007/0-306-47141-8_14 · Cited by 197 · see citing works
Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis.
Irving, H. M., Samokhvalov, A. V., & Rehm, J. T. (2009) · PubMed · Cited by 193 · see citing works
Self-citationBloom, D. M., Chisholm, D., Jané‐Llopis, E., Klaus Prettner, A., Stein, A., & Feigl, A. B. (2011) · RePEc: Research Papers in Economics · Cited by 186 · see citing works
Risky single‐occasion drinking: bingeing is not bingeing
Gmel, G. E., Kuntsche, E. N., & Rehm, J. T. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03167.x · Cited by 185 · cited 1× · see citing works
“For irregular heavy drinking occasions [130, 131], we accept self-reports from surveys as true, even if we know, that they usually underestimate true frequency and number of drinks per occasion.”
BackgroundSelf-citationGmel, G. E., & Rehm, J. T. (2003) · Europe PMC (PubMed Central) · Cited by 182 · see citing works
Self-citationLiver Cirrhosis Mortality in Europe, with Special Attention to Central and Eastern Europe
Zatoński, W. A., Sulkowska, U., Mańczuk, M., Rehm, J., Boffetta, P., Lowenfels, A. B., & La Vecchia, C. (2010) · European Addiction Research · doi:10.1159/000317248 · Cited by 181 · cited 1× · see citing works
“To give one final example concerning chronic disease: high levels of alcoholattributable liver disease mortality point to high overall level of consumption [152, 153], or to relatively high level of consumption combined with other etiological factors for liver disease such as HIV (as even comparatively small levels of…”
BackgroundSelf-citationUsing verbal autopsy to measure causes of death: the comparative performance of existing methods
Murray, C. J. L., Lozano, R., Flaxman, A. D., Serina, P. T., Phillips, D. E., Stewart, A., James, S. L., Vahdatpour, A., Atkinson, C., Freeman, M. K., et al. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-5 · Cited by 167 · cited 1× · see citing works
“, the majority of cause of deaths globally, the basis are verbal autopsies and standardized algorithms to analyze these verbal autopsies and to scale up these results to wider regions [23].”
BackgroundA global action plan for the prevention and control of pneumonia
Greenwood, B. M. (2008) · Bulletin of the World Health Organization · doi:10.2471/blt.08.053348 · Cited by 165 · see citing works
PREVENTION FOR MULTIFACTORIAL DISEASES
Walter, S. D. (1980) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113007 · Cited by 165 · see citing works
Guzzo-Merello, G. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i8.771 · Cited by 162 · see citing works
Risk factors for neuroendocrine neoplasms: a systematic review and meta-analysis
Leoncini, E., Carioli, G., Vecchia, C. L., Boccia, S., & Rindi, G. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv505 · Cited by 161 · cited 1× · see citing works
“Currently other types of cancer are discussed as potentially alcohol-attributable, such as cancer categories of pancreas or stomach cancer, as heavy drinking has been consistently associated with increased risk for these categories [46, 47]; thus, more cancer categories will likely be added to future CRAs.”
BackgroundKehoe, T., Gmel, G., Shield, K. D., Gmel, G., & Rehm, J. (2012) · Population Health Metrics · doi:10.1186/1478-7954-10-6 · Cited by 160 · cited 2× · see citing works
“This implicated different ways to define exposure and to triangulate between national per capita consumption and surveys (see [16, 111] and [110, 112] for the categorical, and the continuous approach respectively).”
BackgroundSelf-citationComparative quantification of alcohol exposure as risk factor for global burden of disease
Rehm, J. T., Klotsche, J., & Patra, J. (2007) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.204 · Cited by 159 · cited 1× · see citing works
“This implicated different ways to define exposure and to triangulate between national per capita consumption and surveys (see [16, 111] and [110, 112] for the categorical, and the continuous approach respectively).”
BackgroundSelf-citationAlcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis
SAMOKHVALOV, A. V., IRVING, H. M., & REHM, J. (2010) · Epidemiology and Infection · doi:10.1017/s0950268810000774 · Cited by 159 · cited 3× · see citing works
“This led to inclusion of these categories from 2010 onwards (underlying documentation: tuberculosis [51]; pneumonia [52]).”
BackgroundSelf-citationEpidemiology and alcohol policy in Europe
Rehm, J. T., Zatonksi, W., Taylor, B., & Anderson, P. (2011) · Addiction · doi:10.1111/j.1360-0443.2010.03326.x · Cited by 147 · cited 3× · see citing works
“Finally, the composition of alcohol-attributable burden of disease and mortality will have different implications for policy [150].”
BackgroundSelf-citationRehm, J. T., Monteiro, M. G., Room, R., Gmel, G. E., Jernigan, D. H., Frick, U., & Graham, K. (2001) · European Addiction Research · doi:10.1159/000050731 · Cited by 142 · cited 2× · see citing works
“, countries with festive drinking such as Mexico; [101, 102]).”
BackgroundSelf-citationKontis, V., Mathers, C. D., Bonita, R., Stevens, G. A., Rehm, J. T., Shield, K. D., Riley, L. M., Poznyak, V. B., Jabbour, S., Garg, R. M., et al. (2015) · The Lancet Global Health · doi:10.1016/s2214-109x(15)00179-5 · Cited by 140 · see citing works
Self-citationFoulds, J., Adamson, S. J., Boden, J. M., Williman, J. A., & Mulder, R. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.024 · Cited by 138 · cited 1× · see citing works
“Maybe some of the newer research on alcohol and depression [67, 68] will allow for better modelling in future CRAs.”
BackgroundRoom, R., Ferris, J., Laslett, A., Livingston, M., Mugavin, J., & Wilkinson, C. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041855 · Cited by 136 · cited 1× · see citing works
“The conceptual framework is there [135], the underlying data for major categories such as traffic injury [136] or for fetal alcohol syndrome/ fetal alcohol spectrum disorders is there (the latter estimated via drinking in pregnant women; [137, 138]) and there are major efforts to improve the methodology for quantifica…”
BackgroundDisability Associated With Alcohol Abuse and Dependence
Samokhvalov, A. V., Popova, S., Room, R., Ramonas, M., & Rehm, J. T. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01275.x · Cited by 131 · cited 1× · see citing works
“This eliminates most categories, which are 100 % alcohol-attributable by definition, except for alcohol use disorders and fetal alcohol syndrome (for some background on burden attached for alcohol use disorders: [39, 40]; for fetal alcohol syndrome [41]), as well as smaller partially attributable categories of disease…”
BackgroundSelf-citationHolmes, J., Meier, P. S., Booth, A., Guo, Y., & Brennan, A. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.005 · Cited by 112 · cited 1× · see citing works
“This clearly is a simplification, as there is usually a lag time between alcohol consumption and disease outcomes [126].”
BackgroundThe World Health Organization's global monitoring system on alcohol and health
Poznyak, V. B. (2013) · Alcohol research · doi:10.35946/arcr.v35.2.15 · Cited by 106 · cited 1× · see citing works
“However, as per capita consumption is derived from administrative records [114], it allows no differentiation by sex and age.”
BackgroundMcKetin, R., Ross, J., Najman, J. M., Baker, A., Lubman, D. I., Dawe, S., Ali, R., Lee, N., Mattick, R., & Mamun, A. A. (2009) · Drug and Alcohol Review · doi:10.1111/j.1465-3362.2009.00130.x · Cited by 103 · see citing works
Evidence of reducing ethanol content in beverages to reduce harmful use of alcohol
Rehm, J. T., Lachenmeier, D. W., Jané‐Llopis, E., Imtiaz, S., & Anderson, P. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30013-9 · Cited by 100 · cited 1× · see citing works
“Other potential ways to decrease overall level of alcohol consumption would be a decrease in alcoholic strength, which is technically possible for all beverages, and which could be achieved via government regulation, taxation or industry initiatives [145].”
BackgroundSelf-citationRabinovich, L., Brutscher, P.-B., de Vries, H., Tiessen, J., Clift, J., & Reding, A. (2009) · Cited by 96 · see citing works
Shield, K. D., & Rehm, J. T. (2012) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1345 · Cited by 93 · see citing works
Self-citationThe impact of alcohol consumption on African people in 2012: an analysis of burden of disease
Ferreira‐Borges, C., Rehm, J. T., Dias, S., Babor, T. F., & Parry, C. D. H. (2015) · Tropical Medicine & International Health · doi:10.1111/tmi.12618 · Cited by 89 · cited 1× · see citing works
“This addition will markedly change the estimates of alcohol-attributable mortality and burden of disease in Sub-Saharan Africa [59].”
BackgroundSelf-citationCHISHOLM, D., DORAN, C., SHIBUYA, K., & REHM, J. (2006) · Drug and Alcohol Review · doi:10.1080/09595230600944487 · Cited by 86 · cited 2× · see citing works
“Such information was seen as important for health policy, especially in terms of primary prevention ([1, 13]; specifically for alcohol see [14, 15]).”
BackgroundSelf-citationEstimating distributions of health state severity for the global burden of disease study
Burstein, R., Fleming, T. D., Haagsma, J., Salomon, J., Vos, T., & Murray, C. (2015) · Population Health Metrics · doi:10.1186/s12963-015-0064-y · Cited by 83 · see citing works
Alcohol and infectious diseases: an overlooked causal linkage?
Parry, C. D. H., Rehm, J. T., Poznyak, V. B., & Room, R. (2009) · Addiction · doi:10.1111/j.1360-0443.2008.02500.x · Cited by 82 · see citing works
Self-citationAdolescent alcohol use and injury. A summary and critical review of the literature.
Sindelar, H. A., Barnett, N. P., & Spirito, A. (2004) · PubMed · Cited by 70 · see citing works
Enhancing the self-report of alcohol consumption in the community: two questionnaire formats.
King, A. C. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.2.294 · Cited by 70 · see citing works
Kovacs, S., Mulholland, K., den Bosch, J. H. W.-V., Campbell, H. J., Forouzanfar, M. H., Khalil, I., Lim, S. S., Liu, L., Maley, S. N., Mathers, C. D., et al. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-014-0728-4 · Cited by 68 · see citing works
Rehm, J. T., Shield, K. D., Roerecke, M., & Gmel, G. E. (2016) · BMC Public Health · doi:10.1186/s12889-016-3026-9 · Cited by 64 · cited 2× · see citing works
“The field of cardiovascular outcomes has been less stable, in part, because two dimensions of alcohol consumption need to be taken into consideration, average volume and patterns of drinking, in particular heavy drinking occasions (in general: [88]; for cardiovascular in particular see [16, 89]), and because there are…”
BackgroundSelf-citationThe Range and Magnitude of Alcohol’s Harm to Others
Laslett, A., Livingston, M., Ferris, J., Dale, C., Doran, C. M., Ferris, J., Jainullabudeen, T. A., Livingston, M., Matthews, S., Mugavin, J., et al. (2010) · eSpace (Curtin University) · Cited by 63 · see citing works
Shied, K. D., Rylett, M., & Rehm, J. T. (2016) · Cited by 60 · see citing works
Self-citationAlcohol Intake Revisited: Risks and Benefits
Roerecke, M., & Rehm, J. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0277-5 · Cited by 58 · cited 1× · see citing works
“Other categories of alcohol-attributable disease and mortality included in current CRAs are fetal alcohol syndrome (by definition), epilepsy [69], gastrointestinal disease (liver cirrhosis [70] and pancreatitis [37, 38]; the latter new for the CRA associated with GBD study 2010 and after), diabetes [71], cardiovascula…”
BackgroundSelf-citationRehm, J., Anderson, P., Gual, A., Kraus, L., Marmet, S., Nutt, D. J., Room, R., Samokhvalov, A. V., Scafato, E., Shield, K. D., et al. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt171 · Cited by 56 · see citing works
Self-citationEDITORIAL Alcohol consumption and mortality. What do we know and where should we go?
Rehm, J. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.9579891.x · Cited by 56 · cited 1× · see citing works
“Moreover, individual consumption may vary, and many risk relations assume more or less a constant consumption over time [127].”
BackgroundSelf-citationLachenmeier, D. W., Kanteres, F., & Rehm, J. T. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq150 · Cited by 55 · see citing works
Self-citationNew Governance of Addictive Substances and Behaviours
Anderson, P., Braddick, F., Conrod, P., Gual, A., Hellman, M., Matrai, S., Miller, D., Nutt, D., Rehm, J. T., Reynolds, J., et al. (2017) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198759836.001.0001 · Cited by 53 · cited 2× · see citing works
“For alcohol consumption, in principle all of the burden is avoidable, but any intervention will have to take into consideration the role alcohol has been playing in our society for thousands of years [13].”
BackgroundSelf-citationCherpitel, C. J., Ye, Y., Bond, J., Borges, G., Monteiro, M., Chou, P., & Hao, W. (2015) · Addiction · doi:10.1111/add.13031 · Cited by 50 · cited 1× · see citing works
“Other categories of alcohol-attributable disease and mortality included in current CRAs are fetal alcohol syndrome (by definition), epilepsy [69], gastrointestinal disease (liver cirrhosis [70] and pancreatitis [37, 38]; the latter new for the CRA associated with GBD study 2010 and after), diabetes [71], cardiovascula…”
BackgroundShield, K. D., & Rehm, J. T. (2015) · BMC Public Health · doi:10.1186/s12889-015-1818-y · Cited by 49 · cited 3× · see citing works
“We have already mentioned the rather strong assumption, that risk relations taken from the most comprehensive meta-analysis are seen as a global constant with exception of Russia and surrounding countries (where the risk relations are based on [98, 99]; see also [84]).”
BackgroundMethodSelf-citationEstimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses
Roerecke, M., Shield, K. D., Higuchi, S., Yoshimura, A., Larsen, E., Rehm, M. X., & Rehm, J. (2015) · Bulletin of the World Health Organization · doi:10.2471/blt.14.142141 · Cited by 44 · cited 2× · see citing works
“based on the interaction between genetics and alcohol consumption in causing cancer; see [104, 132]).”
BackgroundSelf-citationHow much alcohol do you buy? A comparison of self‐reported alcohol purchases with actual sales
Ramstedt, M. (2010) · Addiction · doi:10.1111/j.1360-0443.2009.02839.x · Cited by 42 · cited 1× · see citing works
“The known variation of coverage rates is between 20 % and 90 % (for an example of low coverage: 27 % in Canada [117]; for high coverage see 87 % in Sweden [118] or close to 90 % in New Zealand [119]).”
BackgroundHow should prevalence of alcohol use disorders be assessed globally?
Rehm, J. T. (2016) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1508 · Cited by 42 · cited 1× · see citing works
“A reconceptualization on heavy drinking over time may help overcome these differences [34].”
BackgroundSelf-citationAvoidable burden of disease: conceptual and methodological issues in substance abuse epidemiology
Rehm, J. T., Taylor, B., Patra, J., & Gmel, G. E. (2006) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.199 · Cited by 38 · cited 1× · see citing works
“Obviously, interventions will depend not only on the size and shape of the burden, but also on how much of the alcohol-attributable burden is avoidable [154], and on aspects on feasibility, costs and cost-effectiveness of interventions [14, 15].”
BackgroundSelf-citationGmel, G. E., Shield, K. D., & Rehm, J. T. (2011) · Population Health Metrics · doi:10.1186/1478-7954-9-5 · Cited by 38 · cited 3× · see citing works
“The explanation is simple: it takes quite a lot of alcohol consumption to cause liver cirrhosis often via different stages of liver disease [93], but once liver cirrhosis is established, no matter of what etiology, relatively small Infectious and parasitic diseases Tuberculosis A15-A19 [158] Human immunodeficiency vir…”
BackgroundInfluentialSelf-citationEstimating attributable burden of disease from exposure and hazard data
Hoorn, S. V., Ezzati, M., Rodgers, A., López, A. D., & Murray, C. J. L. (2004) · Cited by 37 · see citing works
Rey, G., Boniol, M., & Jougla, É. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02910.x · Cited by 35 · see citing works
Alcohol-attributable burden of disease and injury in Canada, 2004
Shield, K. D., Kehoe, T., Taylor, B., Patra, J., & Rehm, J. T. (2011) · International Journal of Public Health · doi:10.1007/s00038-011-0247-7 · Cited by 35 · see citing works
Self-citationRehm, J. T., & Frick, U. (2010) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.300 · Cited by 34 · cited 1× · see citing works
“For disability, the data situation is worse than for mortality [25], and estimates are developed based on estimated prevalence of disease categories [26] and disability weights; a disability weight is a factor that reflects the severity of the disease on a scale from 0 (perfect health) to 1 (equivalent to death) [27].”
BackgroundSelf-citationRisk of Myocardial Infarction Immediately After Alcohol Consumption
Mostofsky, E., van der Bom, J. G., Mukamal, K. J., Maclure, M., Tofler, G. H., Muller, J. E., & Mittleman, M. A. (2015) · Epidemiology · doi:10.1097/ede.0000000000000227 · Cited by 33 · cited 1× · see citing works
“The field of cardiovascular outcomes has been less stable, in part, because two dimensions of alcohol consumption need to be taken into consideration, average volume and patterns of drinking, in particular heavy drinking occasions (in general: [88]; for cardiovascular in particular see [16, 89]), and because there are…”
BackgroundRehm, J. T., Rehm, M. X., Alho, H., Allamani, A., Aubin, H., Bühringer, G., Daeppen, J., Frick, U., Gual, A., & Heather, N. (2013) · The International Journal of Alcohol and Drug Research · doi:10.7895/ijadr.v2i2.89 · Cited by 25 · see citing works
Self-citationParry, C., Rehm, J. T., & Morojele, N. K. (2011) · African Journal of Drug and Alcohol Studies · doi:10.4314/ajdas.v9i2.64141 · Cited by 25 · see citing works
Self-citationPatterns of drinking and liver cirrhosis – What do we know and where do we go?
Rehm, J., & Roerecke, M. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.027 · Cited by 22 · cited 1× · see citing works
“Heavy drinking occasions may play an additional role here, but we do not have enough data to quantify this relationship [95].”
BackgroundSelf-citationLange, S., Probst, C., Heer, N., Roerecke, M., Rehm, J. T., Monteiro, M. G., Shield, K. D., de Oliveira, C., & Popova, S. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 22 · see citing works
Self-citationRehm, J. T., Borges, G. L. G., Gmel, G. E., Graham, K., Grant, B. F., Parry, C. D. H., Poznyak, V. B., & Room, R. (2013) · The International Journal of Alcohol and Drug Research · doi:10.7895/ijadr.v2i1.132 · Cited by 19 · cited 4× · see citing works
“The last systematic overview on alcohol use and causal relations to different disease and cause of death categories can be found in [17].”
BackgroundMethodInfluentialSelf-citationPopova, S., Lange, S., Probst, C., Heer, N., Roerecke, M., Rehm, J. T., Monteiro, M. G., Shield, K. D., & de Oliveira, C. (2017) · Revista Panamericana de Salud Pública · doi:10.26633/rpsp.2017.89 · Cited by 17 · cited 1× · see citing works
“The conceptual framework is there [135], the underlying data for major categories such as traffic injury [136] or for fetal alcohol syndrome/ fetal alcohol spectrum disorders is there (the latter estimated via drinking in pregnant women; [137, 138]) and there are major efforts to improve the methodology for quantifica…”
BackgroundSelf-citationLight or moderate drinking is linked to alcohol related cancers, including breast cancer
Rehm, J. (2015) · BMJ · doi:10.1136/bmj.h4400 · Cited by 14 · cited 1× · see citing works
“Even drinking as low as one drink on average is associated with increased risk for breast cancer [85, 86].”
BackgroundSelf-citationRussia: lessons for alcohol epidemiology and alcohol policy
Rehm, J. T. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60038-6 · Cited by 9 · see citing works
Self-citationCommentary on Rey et al. (2010): How to improve estimates on alcohol‐attributable burden?
Rehm, J. T. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02939.x · Cited by 7 · see citing works
Self-citationViolence and unintentional injury: equity and social determinants.
Roberts, H. M., Meddings, D. R., Blas, E., & Kurup, A. S. (2010) · Cited by 7 · see citing works
(2015) · Addiction · doi:10.1111/add.13138 · Cited by 2 · cited 1× · see citing works
“Other categories of alcohol-attributable disease and mortality included in current CRAs are fetal alcohol syndrome (by definition), epilepsy [69], gastrointestinal disease (liver cirrhosis [70] and pancreatitis [37, 38]; the latter new for the CRA associated with GBD study 2010 and after), diabetes [71], cardiovascula…”
BackgroundSelf-citationRISKY SINGLE OCCASION DRINKING RESEARCH: THE FOUR STAGES OF ENLIGHTENMENT
Gmel, G. E., Kuntsche, E. N., & Rehm, J. T. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03438.x · Cited by 1 · cited 1× · see citing works
“For irregular heavy drinking occasions [130, 131], we accept self-reports from surveys as true, even if we know, that they usually underestimate true frequency and number of drinks per occasion.”
BackgroundSelf-citationThe Burden of Disease and Injury Caused by Alcohol☆
Shield, K. D., Popova, S., & Rehm, J. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03188-3 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
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The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204 · see citing works
Self-citationGlobal alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study
Manthey, J., Shield, K. D., Rylett, M., Hasan, O. S. M., Probst, C., & Rehm, J. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32744-2 · Cited by 856 · see citing works
Self-citationWang, H., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abera, S. F., Abraha, H. N., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31833-0 · Cited by 801 · see citing works
Shield, K. D., Manthey, J., Rylett, M., Probst, C., Wettlaufer, A., Parry, C. D. H., & Rehm, J. T. (2020) · The Lancet Public Health · doi:10.1016/s2468-2667(19)30231-2 · Cited by 528 · see citing works
Self-citationThe Global Burden of Liver Disease.
Younossi, Z., Wong, G. S. W., Anstee, Q., & Henry, L. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.04.015 · Cited by 467 · see citing works
Global Burden of Alcohol Use Disorders and Alcohol Liver Disease
Rehm, J. T., & Shield, K. D. (2019) · Biomedicines · doi:10.3390/biomedicines7040099 · Cited by 225 · see citing works
“Alcohol use is a major risk factor for mortality and morbidity, playing a role in more than 200 diseases and injury outcomes [1,2].”
BackgroundSelf-citationManthey, J., Hassan, S. A., Carr, S., Kilian, C., Kuitunen‐Paul, S., & Rehm, J. T. (2021) · PharmacoEconomics · doi:10.1007/s40273-021-01031-8 · Cited by 173 · see citing works
Self-citationDrapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. M., Викторович, А. М., Alexandrova, L. M., Анциферова, А. А., Dm, A., Ахмеджанов, Н. М., Balanova, Y. А., et al. (2022) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2022-3235 · Cited by 178 · see citing works
Стародубов, В. И., Marczak, L. B., Varavikova, E. A., Bikbov, B. T., Ermakov, S. P., Gall, J., Glenn, S., Griswold, M., Idrisov, B. T., Kravchenko, M. A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31485-5 · Cited by 114 · see citing works
Schwarzinger, M., Thiébaut, S. P., Baillot, S., Mallet, V., & Rehm, J. (2018) · BMC Public Health · doi:10.1186/s12889-017-4587-y · Cited by 94 · see citing works
Self-citationQuantifying the contribution of alcohol to cardiomyopathy: A systematic review
Rehm, J., Hasan, O. S. M., Imtiaz, S., & Neufeld, M. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.011 · Cited by 92 · see citing works
Self-citationKetogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
Wiers, C. E., Vendruscolo, L. F., van der Veen, J.-W., Manza, P., Kojori, E. S., Kroll, D. S., Feldman, D. E., McPherson, K. L., Biesecker, C. L., Zhang, R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf6780 · Cited by 74 · see citing works
“INTRODUCTION Alcohol use disorder (AUD) is a chronic, relapsing brain disorder that accounts for 5% of deaths globally (1).”
BackgroundAmes, N. J., Barb, J. J., Schuebel, K. E., Mudra, S. E., Meeks, B., Tuason, R. T. S., Brooks, A. T., Kazmi, N., Yang, S. B., Ratteree, K., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1758010 · Cited by 67 · see citing works
“elevated cancer risk,(19) immune system dysfunction,20 heart failure,(21) and many other significant health problems.(22) Some of these consequences of alcohol use have been attributed to alcohol-induced gut dysbiosis – an imbalance in the community of gut microbes.”
BackgroundŠtelemėkas, M., Manthey, J., Badaras, R., Casswell, S., Ferreira‐Borges, C., Kalèdiené, R., Lange, S., Neufeld, M., Petkevičienė, J., Radišauskas, R., et al. (2021) · Addiction · doi:10.1111/add.15470 · Cited by 68 · see citing works
Self-citationAlcohol Use and Cancer in the European Union
Rehm, J. T., & Shield, K. D. (2020) · European Addiction Research · doi:10.1159/000507017 · Cited by 66 · see citing works
“Two systematic reviews and meta-analyses provide the most comprehensive and comparable overviews on risk relations [16, 17], and serve as the basis for the latest comparative risk analyses for alcohol (for an overview of comparative risk assessments, see [18]).”
BackgroundSelf-citationCollagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats
Chacon, E. L., Bertolo, M. R. V., Plepis, A. M. D. G., Martins, V. D. C. A., dos Santos, G. R., Pinto, C. A. L., Pelegrine, A. A., Teixeira, M. L., Buchaim, D. V., Nazari, F. M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-022-24424-x · Cited by 57 · see citing works
Trends in U.S. women’s binge drinking in middle adulthood by socioeconomic status, 2006–2018
McKetta, S. C., & Keyes, K. M. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108026 · Cited by 56 · see citing works
“Regular patterns of binge drinking over time increase the risks of cardiovascular disease, cancer, liver damage, and other morbidities (Rehm and Imtiaz, 2016).”
BackgroundSex differences in the medial prefrontal cortical glutamate system
Knouse, M. C., McGrath, A. G., Deutschmann, A. U., Rich, M. T., Zallar, L. J., Rajadhyaksha, A. M., & Briand, L. A. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00468-6 · Cited by 55 · see citing works
Alcohol control policy and changes in alcohol‐related traffic harm
Rehm, J. T., Manthey, J., Lange, S., Badaras, R., Zurlytė, I., Passmore, J. W., Breda, J., Ferreira‐Borges, C., & Štelemėkas, M. (2019) · Addiction · doi:10.1111/add.14796 · Cited by 53 · see citing works
Self-citationSornpaisarn, B., Shield, K. D., Manthey, J., Limmade, Y., Low, W. Y., Vo, T. V., & Rehm, J. T. (2020) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2020.102856 · Cited by 53 · see citing works
Self-citationRehm, J. T., & Hasan, O. S. M. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.06.005 · Cited by 49 · see citing works
Self-citationShmulewitz, D., Aharonovich, E., Witkiewitz, K. A., Anton, R. F., Kranzler, H. R., Scodes, J. M., Mann, K. F., Wall, M. M., & Hasin, D. S. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20050610 · Cited by 53 · see citing works
Rehm, J. T., Badaras, R., Ferreira‐Borges, C., Galkus, L., Midttun, N. G., Gobiņa, I., Janik‐Koncewicz, K., Jasilionis, D., Jiang, H., Kim, K. V., et al. (2023) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2023.100704 · Cited by 51 · see citing works
Self-citationThe global proportion and volume of unrecorded alcohol in 2015
Probst, C., Fleischmann, A., Gmel, G. E., Poznyak, V. B., Rekve, D., Riley, L. M., Rylett, M., Shield, K. D., & Rehm, J. T. (2019) · Journal of Global Health · doi:10.7189/jogh.09.010421 · Cited by 50 · see citing works
Self-citationAlcohol Control Policy in Europe: Overview and Exemplary Countries
Berdzuli, N., Ferreira‐Borges, C., Gual, A., & Rehm, J. T. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218162 · Cited by 45 · see citing works
Self-citationEstimation of cancers caused by light to moderate alcohol consumption in the European Union
Rovira, P., & Rehm, J. T. (2020) · European Journal of Public Health · doi:10.1093/eurpub/ckaa236 · Cited by 47 · see citing works
Self-citationStaton, C. A., Vissoci, J. R. N., El-Gabri, D., Adewumi, K., Concepcion, T., Elliott, S. A., Evans, D. R., Galson, S. W., Pate, C. T., Reynolds, L. M., et al. (2022) · PLOS Medicine · doi:10.1371/journal.pmed.1003961 · Cited by 41 · see citing works
What is the best indicator of the harmful use of alcohol? A narrative review
Rehm, J. T., Crépault, J., Wettlaufer, A., Manthey, J., & Shield, K. D. (2020) · Drug and Alcohol Review · doi:10.1111/dar.13053 · Cited by 43 · see citing works
Self-citationRehm, J. T., Neufeld, M., Room, R., Sornpaisarn, B., Štelemėkas, M., Swahn, M. H., & Lachenmeier, D. W. (2021) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103420 · Cited by 41 · see citing works
Self-citationResearch Protocol to Evaluate the Effects of Alcohol Policy Changes in Lithuania
Rehm, J. T., Štelemėkas, M., & Badaras, R. (2018) · Alcohol and Alcoholism · doi:10.1093/alcalc/agy068 · Cited by 40 · see citing works
Self-citationNeufeld, M., Rovira, P., Ferreira‐Borges, C., Kilian, C., Sassi, F., Veryga, A., & Rehm, J. T. (2022) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2022.100325 · Cited by 40 · see citing works
Self-citationSocietal development and the alcohol‐attributable burden of disease
Shield, K. D., & Rehm, J. T. (2021) · Addiction · doi:10.1111/add.15441 · Cited by 37 · see citing works
Self-citationRehm, J. T., Anderson, P., Prieto, J. A. A., Armstrong, I. J., Aubin, H., Bachmann, M., Bastús, N. B., Brotons, C., Burton, R., Cardoso, M., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0934-1 · Cited by 36 · see citing works
“The next set of calculations measures the impact of the proposed interventions on mortality and burden of disease as measured in disability-adjusted live years (DALYs) in the same age group within 1 year, using the methodology of comparative risk assessment [62, 63] (see Additional file 2: Appendix 2).”
MethodSelf-citationRehm, J. T., Lange, S., Gobiņa, I., Janik‐Koncewicz, K., Miščikienė, L., Reile, R., Stoppel, R., Tran, A., Ferreira‐Borges, C., Jasilionis, D., et al. (2022) · Addiction · doi:10.1111/add.16102 · Cited by 35 · see citing works
Self-citationIvsins, A., Pauly, B., Brown, M. E., Evans, J., Gray, E., Schiff, R., Krysowaty, B., Vallance, K., & Stockwell, T. R. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.02.004 · Cited by 36 · see citing works
Wang, G., Fu, Y., Li, J., Li, Y., Zhao, Q., Hu, A., Xu, C., Shao, D., & Chen, W. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13537 · Cited by 34 · see citing works
Williams, E. C., Frost, M. C., Rubinsky, A. D., Glass, J. E., Wheat, C. L., Edmonds, A. T., Chen, J. A., Matson, T. E., Fletcher, O. V., Lehavot, K., et al. (2021) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2021.82.132 · Cited by 35 · see citing works
“Unhealthy alcohol use (Saitz, 2005)—particularly heavy episodic drinking and alcohol use disorders—increases risk of acute and chronic conditions (GBD 2016 Alcohol Collaborators, 2018; Rehm & Imtiaz, 2016).”
BackgroundTrends in US Alcohol Consumption Frequency During the First Wave of the SARS‐CoV‐2 Pandemic
McKetta, S. C., Morrison, C. N., & Keyes, K. M. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14575 · Cited by 33 · see citing works
“…alcohol consumption could be anticipated to lead to a variety of morbidity and mortality outcomes including heart disease, metabolic diseases, liver disease, and cancers (Bagnardi et al., 2015; Kuypers et al., 2012; Mellinger, 2019; Rehm and Imtiaz, 2016; Skog, 2001; Tramacere et al., ,2010, 2011).”
BackgroundMüller, C. P., Schumann, G., Rehm, J. T., Kornhuber, J., & Lenz, B. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02074-3 · Cited by 34 · see citing works
Self-citationAlcohol and gender gaps in life expectancy in eight Central and Eastern European countries
Trias‐Llimós, S., & Janssen, F. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky057 · Cited by 31 · see citing works
Prevalence of Alcohol and Tobacco Use among Men and Women in Namibia
He, Z., Bishwajit, G., & Yaya, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16010059 · Cited by 30 · see citing works
“of Diseases, Revision 10 [ICD-10]), among which there are about 40 of which alcohol is the sole risk factor [7].”
BackgroundLamarão-Vieira, K., Pamplona-Santos, D., Nascimento, P. C., Corrêa, M. G., Bittencourt, L. O., dos Santos, S. M., Cartágenes, S. D. C., Fernandes, L. M. P., Monteiro, M. C., Maia, C. D. S. F., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6802424 · Cited by 30 · see citing works
“From the pharmacological point of view, EtOH is a dosedependent psychotropic drug that when consumed in large proportions increases the risk ofmorbidity and/ormortality [2, 3].”
BackgroundCerebral Hemorrhage and Alcohol Exposure: A Review
Peng, J., Wang, H., Rong, X., He, L., Xiang-pen, L., Shen, Q., & Peng, Y. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz087 · Cited by 27 · see citing works
SANTAMARINE: Mechanistic studies on multiple diseases
Jalal, S., Ahmad, B., Zhang, T., Guo, L., & Huang, L. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13666 · Cited by 27 · see citing works
“Alcohol utilization has been recognized as a main cause of varied disorders and death in all global comparative risk assessments (CRAs) (Rehm & Imtiaz, 2016) as part of the global burden of disease (GBD) studies (Forouzanfar et al., 2015; Rehm et al., 2001).”
BackgroundThe cost-effectiveness of therapies to treat alcohol use disorders
Rehm, J. T., & Barbosa, C. (2017) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2018.1392241 · Cited by 28 · see citing works
Self-citationPotential of resveratrol in mitigating metabolic disturbances induced by ethanol
Szkudelski, T., & Szkudelska, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.063 · Cited by 26 · see citing works
Trias‐Llimós, S., Martikainen, P., Mäkelä, P., & Janssen, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194478 · Cited by 26 · see citing works
Quantifying the global contribution of alcohol consumption to cardiomyopathy
Manthey, J., Imtiaz, S., Neufeld, M., Rylett, M., & Rehm, J. T. (2017) · Population Health Metrics · doi:10.1186/s12963-017-0137-1 · Cited by 24 · see citing works
Self-citationBjørkhaug, S. T., Neupane, S. P., Bramness, J. G., Aanes, H., Skar, V., Medhus, A. W., & Valeur, J. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.10.002 · Cited by 24 · see citing works
Jayathilaka, R., Athukorala, O., Ishara, S., Silva, D., & Pathirage, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270998 · Cited by 24 · see citing works
“Alcohol utilisation may be a hazard substantially impacting on the burden of diseases [4].”
BackgroundCheng, Z., Chen, F., Zuo, E., Gong, Z., Xiao, M., Li, C., Liu, Y., Liu, Y., Chen, C., Lv, X., et al. (2025) · Expert Systems with Applications · doi:10.1016/j.eswa.2025.127462 · Cited by 24 · see citing works
Xie, Z., Zhong, G., Xu, C., Chen, T., Du, Z., Wei, Y., Zhao, M. J., & Du, J. (2025) · Globalization and Health · doi:10.1186/s12992-025-01124-5 · Cited by 24 · see citing works
“Alcohol use disorder (AUD) is one of the major disorders worldwide that seriously affects the quality of life of modern people [1, 2].”
Tran, A., Jiang, H., Kim, K. V., Room, R., Štelemėkas, M., Lange, S., Rovira, P., & Rehm, J. T. (2022) · Alcohol and Alcoholism · doi:10.1093/alcalc/agac003 · Cited by 23 · see citing works
Self-citationKarriker‐Jaffe, K. J., Lönn, S. L., Cook, W. K., Kendler, K. S., & Sundquist, K. (2018) · Health & Place · doi:10.1016/j.healthplace.2017.12.008 · Cited by 23 · see citing works
“Alcohol use disorders (AUD) are debilitating, multi-faceted, recurrent conditions that impose a significant burden on the global population every year (Odlaug et al., 2016; Rehm and Imtiaz, 2016; Rehm et al., 2006; Whiteford et al., 2013).”
Imtiaz, S., Probst, C., & Rehm, J. T. (2018) · Drug and Alcohol Review · doi:10.1111/dar.12616 · Cited by 23 · see citing works
Self-citationReducing the Harmful Use of Alcohol: Have International Targets Been Met?
Rehm, J. T., Casswell, S., Manthey, J., Room, R., & Shield, K. D. (2020) · European Journal of Risk Regulation · doi:10.1017/err.2020.84 · Cited by 22 · see citing works
Self-citationKiadaliri, A. (2021) · BMC Public Health · doi:10.1186/s12889-021-10567-5 · Cited by 22 · see citing works
“It should be noted that smoking and alcohol consumption are also associated with increased risk of IHD mortality [35, 42].”
BackgroundSpoth, R. L., Redmond, C. R., Shin, C., Trudeau, L., Greenberg, M. T., Feinberg, M. E., & Welsh, J. A. (2022) · Child Development · doi:10.1111/cdev.13746 · Cited by 22 · see citing works
Ji, A.-L., Lou, P., Dong, Z., Xu, C., Zhang, P., Chang, G., & Li, T. (2018) · BMC Public Health · doi:10.1186/s12889-018-5276-1 · Cited by 21 · see citing works
“1% of global disability-adjusted life-years is attributed to alcohol [4], and the annualized death rates for alcohol dependence are 4.”
BackgroundRuggeri, S., Buonocore, P., & Amoriello, T. (2022) · Nutrients · doi:10.3390/nu14235177 · Cited by 23 · see citing works
Marts, L. T., Green, D. E., Mills, S. T., Murphy, T., & Sueblinvong, V. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13496 · Cited by 21 · see citing works
“Furthermore, long-term alcohol ingestion is associated with significant organ dysfunction, and increased burden of mental disorders, lung disease, cancer, infection, and cirrhosis (Rehm and Imtiaz, 2016, Kershaw and Guidot, 2008).”
InfluentialChanges in alcohol consumption in Spain between 1990 and 2019
Llamosas‐Falcón, L., Manthey, J., & Rehm, J. T. (2020) · Adicciones · doi:10.20882/adicciones.1400 · Cited by 20 · see citing works
“ADICCIONES, 2020 · VOL. xx NO. x · PAGES xx-xx A lcohol use has been identified as a major risk factor for global mortality and burden of disease (Rehm & Imtiaz, 2016).”
BackgroundSelf-citationAlcohol and Noncommunicable Disease Risk
Rehm, J. T., Hasan, O. S. M., Imtiaz, S., Probst, C., Roerecke, M., & Shield, K. D. (2018) · Current Addiction Reports · doi:10.1007/s40429-018-0189-8 · Cited by 21 · see citing works
Self-citationRehm, J. T., O'Donnell, A. J., Kaner, E., Jané‐Llopis, E., Manthey, J., & Anderson, P. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-054161 · Cited by 19 · see citing works
Self-citationRibeiro, L. S., Damacena, G. N., & Szwarcwald, C. L. (2021) · Revista Brasileira de Epidemiologia · doi:10.1590/1980-549720210042 · Cited by 18 · see citing works
Heterogeneity in trends of alcohol use around the world: Do policies make a difference?
Rehm, J. T., Babor, T. F., Casswell, S., & Room, R. (2021) · Drug and Alcohol Review · doi:10.1111/dar.13248 · Cited by 18 · see citing works
Self-citationSun, X., Ho, J. E., Gao, H., Εvangelou, Ε., Yao, C., Huan, T., Hwang, S., Courchesne, P. L., Larson, M. G., Levy, D. A., et al. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab186 · Cited by 17 · see citing works
A systematic comparison of the global comparative risk assessments for alcohol
Chrystoja, B. R., Rehm, J. T., Manthey, J., Probst, C., Wettlaufer, A., & Shield, K. D. (2021) · Addiction · doi:10.1111/add.15413 · Cited by 17 · see citing works
Self-citationOchi, R., Ueno, F., Sakuma, M., Tani, H., Tsugawa, S., Graff‐Guerrero, A., Uchida, H., Mimura, M., Oshima, S., Matsushita, S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12035-5 · Cited by 16 · see citing works
“The present study enhances our understanding of the mechanism of action of alcohol by showing that (1) acute alcohol increases log(lFCD) across regions including visual cortex, temporal cortex, thalamus, striatum, and cerebellum; (2) the increased log(lFCD) is normalized in the 90-min post condition; (3) log(lFCD) in…”
BackgroundMethodFuruya, S., Argemí, J., Uehara, T., Katou, Y., Fouts, D. E., Schnabl, B., Dubuquoy, L., Belorkar, A., Vadigepalli, R., Kono, H., et al. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14234 · Cited by 15 · see citing works
“…alcohol intake is a leading risk factor for global disease burden and is a major cause of preventable morbidity and mortality worldwide (Collaborators GBDA, 2018) due to adverse effects on multiple organs (Rusyn and Bataller, 2013), accidents, and violence (Rehm and Imtiaz, 2016).”
BackgroundManthey, J., Solovei, A., Anderson, P., Carr, S., & Rehm, J. T. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255843 · Cited by 17 · see citing works
Self-citationSelf‐Compassion and Self‐Forgiveness in Alcohol Risk, Treatment and Recovery: A Systematic Review
Berg, S. J., Zaso, M. J., Biehler, K. M., & Read, J. P. (2024) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2987 · Cited by 14 · see citing works
Mehrabi, M., Hajebi, A., Mohebbi, E., Baneshi, M. R., Khodadost, M., Haghdoost, A. A., Sharifi, H. P., & Noroozi, A. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1578909 · Cited by 15 · see citing works
“Alcohol negatively affects the course and prognosis of many diseases (Rehm and Imtiaz 2016).”
BackgroundMental health disorders research in Europe, 2001–2018
Begum, M., Lewison, G., Woelbert, E., Brigham, K. B., Darlington, M., Durand‐Zaleski, I., & Sullivan, R. J. (2020) · Evidence-Based Mental Health · doi:10.1136/ebmental-2019-300130 · Cited by 14 · see citing works
The impact of the COVID-19 pandemic on alcohol and tobacco consumption: Evidence from Peru
Sara, R. (2023) · Social Science & Medicine · doi:10.1016/j.socscimed.2023.115890 · Cited by 13 · see citing works
“Heavy use of alcohol and tobacco hold some of the leading causes of mortality and morbidity in the world (Cawley and Ruhm, 2011; Rehm and Imtiaz, 2016; Shield et al., 2020).”
Touis, L. Z., Bolbrinker, J., Riemer, T., & Kreutz, R. H. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022026 · Cited by 13 · see citing works
Shield, K. D., Chrystoja, B. R., Ali, S., Sohi, I., Rehm, J. T., Nigatu, Y. T., Elton‐Marshall, T., Hamilton, H. A., Jankowicz, D., & Wells, S. L. (2021) · Alcohol and Alcoholism · doi:10.1093/alcalc/agab055 · Cited by 12 · see citing works
Self-citationKetogenic diet reduces a neurobiological craving signature in inpatients with alcohol use disorder
Wiers, C. E., Manza, P., Wang, G., & Volkow, N. D. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1254341 · Cited by 11 · see citing works
Alcohol Use and Cancers of the Gastrointestinal Tract. Epidemiology and Preventive Implications
Rehm, J. T., & Shield, K. D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00403 · Cited by 11 · see citing works
“Shield and colleagues performed a comparative risk assessment for alcohol (19) based on the tradition of the Global Burden of Disease Studies [last assessment published: (20) and the WHO Global Status Reports on Alcohol and Health [last: (21)].”
BackgroundSelf-citationDiscrimination of alcohol dependence based on the convolutional neural network
Chen, F., Xiao, M., Chen, C., Chen, C., Yan, Z., Han, H., Zhang, S., Yue, F., Gao, R. H., & Lv, X. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241268 · Cited by 11 · see citing works
Meaning in life: investigating protective and risk factors for harmful alcohol consumption
Copeland, A., Jones, A., Acuff, S. F., Murphy, J. G., & Field, M. (2022) · Addiction Research & Theory · doi:10.1080/16066359.2022.2134991 · Cited by 10 · see citing works
“Excessive alcohol consumption results in an array of adverse social and economic outcomes (Rehm and Imtiaz 2016).”
BackgroundAlcohol use disorders in patients with bipolar disorder: a systematic review and meta-analysis
Pedro, M. O. P., Pedro, M. P., Martins, S. S., & Castaldelli-Maia, J. M. (2023) · International Review of Psychiatry · doi:10.1080/09540261.2023.2249548 · Cited by 11 · see citing works
“Alcohol consumption is an important risk factor for mortality and morbidity, playing a role in more than 200 diseases and health damages (Rehm & Imtiaz, 2016).”
BackgroundZhang, N., Xue, F., Wu, X., Zhang, W., Hou, J., Xiang, J., Lv, Y., & Zhang, X. (2023) · Alcohol and Alcoholism · doi:10.1093/alcalc/agad046 · Cited by 11 · see citing works
Andreacchi, A. T., Hobin, E. P., Siddiqi, A., & Smith, B. T. (2024) · Addiction · doi:10.1111/add.16641 · Cited by 11 · see citing works
Sornpaisarn, B., & Rehm, J. T. (2020) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2020.102975 · Cited by 10 · see citing works
Self-citationHorton, M., Perman‐Howe, P. R., Angus, C., Bishop, J., Bogdanovica, I., Brennan, A., Britton, J. R., Brose, L. S., Brown, J., Collin, J., et al. (2021) · Wellcome Open Research · doi:10.12688/wellcomeopenres.16318.1 · Cited by 10 · see citing works
Agmatine prevents development of tolerance to anti-nociceptive effect of ethanol in mice
Kotagale, N. R., Bhondekar, S., Bhad, M., Pise, S., Charpe, A., Umekar, M. J., & Taksande, B. G. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.02.004 · Cited by 10 · see citing works
Wolter, D. K. (2018) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-018-1440-6 · Cited by 10 · see citing works
Rehm, J. T., Jiang, H., Hassan, A. S., Rovira, P., & Shield, K. D. (2025) · BMJ Public Health · doi:10.1136/bmjph-2024-001453 · Cited by 9 · see citing works
“6 Alcohol consumption has been established as a key risk factor in all comparative risk assessments to date 14 (for an early WHO report, see 15 ).”
Self-citationCarr, S., Dice, A. L. E., Gmel, G. E., Hassan, A. S., Shield, K. D., & Rehm, J. T. (2026) · Addiction · doi:10.1111/add.70435 · Cited by 12 · see citing works
“These studies are theoretically less susceptible to the confounding biases inherent in other observational research [3] and have frequently reported risk estimates differing from those derived from cohort or case – control studies — often suggesting no associations, or even associations in opposite…”
Self-citationWillemse, L., Terburgh, K., & Louw, R. (2023) · Metabolomics · doi:10.1007/s11306-023-02006-w · Cited by 9 · see citing works
“Moreover, an increase in worldwide alcohol consumption has been observed, where alcohol use disorder (AUD) has been linked to around 5% of global deaths (Rehm & Imtiaz, 2016).”
BackgroundRehm, J. T., Ferreira‐Borges, C., Kokole, D., Neufeld, M., Olsen, A., Rovira, P., Segura, L., Tran, A., & Colom, J. (2023) · Drug and Alcohol Review · doi:10.1111/dar.13676 · Cited by 9 · see citing works
Self-citationHan, W., Li, H., Jiang, H., Xu, H., Lin, Y., Chen, J., Bi, C., & Liu, Z. (2023) · PeerJ · doi:10.7717/peerj.15977 · Cited by 10 · see citing works
Alcohol use, economic development and health burden: A conceptual framework
Rehm, J. T., Rovira, P., Shield, K. D., Sornpaisarn, B., Vo, T. V., & Room, R. (2024) · The International Journal of Alcohol and Drug Research · doi:10.7895/ijadr.437 · Cited by 11 · see citing works
Self-citationCopeland, A., Stafford, T., & Field, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816720-5.00002-5 · Cited by 9 · see citing works
Neveu, W. A., Staitieh, B. S., Mills, S. T., Guidot, D. M., & Sueblinvong, V. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14110 · Cited by 9 · see citing works
“Keywords alcohol; myofibroblast; Thy-1; IL-17; TGFβ1 INTRODUCTION Chronic alcohol ingestion causes significant dysfunction of several organs, including the brain, immune system, liver, and lung (Rehm and Imtiaz, 2016, Kershaw and Guidot, 2008).”
BackgroundGuidelines and reality in studies on the economic costs of alcohol use: a systematic review
Carr, S., Rehm, J. T., & Manthey, J. (2021) · The International Journal of Alcohol and Drug Research · doi:10.7895/ijadr.283 · Cited by 9 · see citing works
“Alcohol consumption has been identified as a leading risk factor for disease burden globally (Rehm & Imtiaz, 2016; Stanaway et al., 2018) and was accountable for about 5% of all deaths in 2016 (Shield et al., 2020).”
BackgroundSelf-citationShojima, K., Mori, T., Wada, Y., Kusunoki, H., Tamaki, K., Matsuzawa, R., Nagai, K., Goto, M., Tabuchi, T., Nagasawa, Y., et al. (2024) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14835 · Cited by 8 · see citing works
“31 Appropriate alcohol consumption, however, might positively affect social relationships in a rural community.”
BackgroundKokole, D., Jané‐Llopis, E., Mercken, L. A. G., Piazza, M., Bustamante, I. V., Rey, G. N., Medina, P., Pérez‐Gómez, A., Mejía‐Trujillo, J., O'Donnell, A. J., et al. (2021) · Substance Abuse · doi:10.1080/08897077.2021.1903658 · Cited by 8 · see citing works
What about drinking is associated with shorter life in poorer people?
Rehm, J. T., & Probst, C. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002477 · Cited by 8 · see citing works
Self-citation
- Authors
- Rehm, J., & Imtiaz, S.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Rehm, Jürgen
- Venue
- Substance Abuse Treatment, Prevention, and Policy
- Published
- 2016-10-28
- Volume
- 11
- Issue
- 1
- Pages
- 37-37
- ISSN
- 1747-597X (ISSN-L)
- PMC
- PMC5084343
- OpenAlex
- W2541740194
- Cited by
- 177
- References
- 154
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 13 · 2023: 19 · 2022: 21 · 2021: 28 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 12
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Substance Abuse Treatment Prevention and Policy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion, cc-by)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (HHSN267200700041C)
- World Health Organization (n.a.)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Business, Management and Accounting › Organizational Behavior and Human Resource Management › Global Public Health Policies and Epidemiology
- Keywords
- alcohol consumption, alcohol-related harm, global burden of disease, comparative risk assessment, alcohol-attributable mortality, causality, alcohol policy
- MeSH terms
- Global Burden of Disease, Alcohol Drinking, Cause of Death, Health Policy, Humans, Risk Factors, Risk Assessment
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