A structural variant at ASIP associated with the darkness of hair coat is found in multiple zebu cattle populations
Open accessAbstract
A structural variant (SV) in the agouti signaling protein gene (ASIP), namely ASIP-SV1, has been found to strongly correlate with the darkness of hair coat in specific regions of the body of bulls from the zebu (Bos indicus) Nellore breed. Here we visually analyzed the whole-genome sequence of zebu and taurine (Bos taurus) cattle to elucidate the extent of spread of ASIP-SV1 in different cattle populations. Of 216 sequences analyzed, 63 zebu (45.9%) and five taurine (6.3%) animals had at least one copy of ASIP-SV1. Four of the taurine animals presenting the SV were Romagnola cattle, a breed with history of zebu introgression. The remaining taurine animal was a Simmental, a breed frequently used in crossbreeding. These data provide evidence that ASIP-SV1 is commonly found in zebu populations, in addition to taurine animals with zebu admixture.
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Structural variations in ASIP are prevalent in zebu cattle populations (45.9%).
“Structural variations in ASIP are prevalent in zebu cattle populations (45.9%) [141].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [141]
Cites
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Variants at the ASIP locus contribute to coat color darkening in Nellore cattle
Trigo, B. B., Utsunomiya, A. T. H., Fortunato, A. A. A. D., Milanesi, M., Torrecilha, R. B. P., Lamb, H. J., Nguyen, L. T., Ross, E. M., Hayes, B. J., Padula, R. C. M., et al. (2021) · Genetics Selection Evolution · doi:10.1186/s12711-021-00633-2 · Cited by 61 · see citing works
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Self-citationIntrogression contributes to distribution of structural variations in cattle
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Bos taurus haplotypes segregating in Nellore (Bos indicus) cattle
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The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution
Liu, Y., Dao, W., Gao, R., Fan, X., Yang, R., & Miao, Y. (2026) · Animals · doi:10.3390/ani16050776 · Cited by 1 · see citing works
- Authors
- Trigo, B. B., Alves, N. F., Milanesi, M., Garcia, J. F., Terefe, E., Hanotte, O., Tijjani, A., & Utsunomiya, Y. T.
- Affiliations
- International Atomic Energy Agency (AT)
- Università degli Studi della Tuscia (IT)
- International Livestock Research Institute (KE)
- Jackson Laboratory (US)
- Universidade Estadual Paulista (Unesp) (BR)
- Corresponding author
- Utsunomiya, Yuri Tani
- ORCID
- Venue
- Animal Genetics
- Publisher
- Wiley
- Published
- 2023-06-14
- Volume
- 54
- Issue
- 4
- Pages
- 544-548
- ISSN
- 0268-9146 (ISSN-L)
- 1365-2052
- OpenAlex
- W4380576629
- Cited by
- 6
- References
- 9
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Animal Genetics (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research) (submittedVersion)
- UnitusOpen (Tuscia University) (submittedVersion, cc-by-nc-nd)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2020/07051‐3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Livestock Farming and Management
- Keywords
- ASIP, structural variants, coat color inheritance, Bos indicus, Nellore, taurine cattle, Simmental cattle, cattle
- MeSH terms
- Alleles, Animals, Cattle, Darkness, Hair, Hybridization, Genetic, Male
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