Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis
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BACKGROUND: Dermatological illness can affect the quality of life and may coexist with psychiatric disorders. OBJECTIVE: The aim of this review was to systematically evaluate the published evidence of any psychiatric disorders that may coexist with chronic urticaria (CU) and any effect psychiatric interventions may have on CU. METHODS: Following the Cochrane guidance, we conducted a systematic literature search using web-based search engines provided by PubMed (for Medline database), Google Scholar and Scopus for studies that have investigated the existence of psychiatric comorbidity in patients with CU. To be included, a study had to possess features, such as: (1) distinction between chronic urticaria and allergic conditions, (2) direct collection of diagnostic psychiatric data by using clinical interview and standardized questionnaires, (3) International Classification of Disorders criteria or the Diagnostic and Statistical Manual of Mental Disorders criteria for the diagnosis of mental disorders, and (4) manuscripts written or published in the English language. Unpublished research and research in progress were not included. All the eligible studies were scrutinized for any reported psychiatric interventions that had any effect on CU. The systematic review has been registered on PROSPERO (registration number CRD42019122811) and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). RESULTS: Twenty-five studies were identified. Almost one out of three CU patients have at least one underlying psychiatric disorder. None of the studies clarified whether the psychiatric disorders pre-existed the CU onset, and no association was found between CU severity and duration, and psychological functioning. Only one case report and two case series mentioned that treatment of psychiatric disorders with either anti-depressants, anti-anxiety drugs or psychological interventions might result in improvement of urticaria. CONCLUSIONS: Patients with CU frequently experience psychiatric disorders. This highlights the need for a multidisciplinary therapeutic approach involving prompt recognition and management of any potential psychiatric disorder in addition to urticaria treatment. Further studies are needed to assess whether psychiatric disorders coexist with CU independently or follow urticaria onset and whether any psychological or psychiatric intervention may help in CU control.
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Psychotropic drugs could have a positive effect on CSU treatment.
“Psychotropic drugs (e.g., antidepressants and benzodiazepines) could have a positive effect on CSU treatment 11,31 .”
From Could distress tolerance levels be associated with the severity of chronic spontaneous urticaria? (2022) · cites this paper as [31]
The Results section on psychiatric interventions reports case studies in which antidepressants or anti-anxiety drugs may have improved urticaria, and the Discussion says psychotropic therapy may affect chronic urticaria (CU) control. The paper frames this evidence as preliminary and does not identify those patients specifically as having chronic spontaneous urticaria (CSU), so it does not fully support the claim's narrower population. (LLM, conf=0.84)
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Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334 · see citing works
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822 · see citing works
Zuberbier, T., Aberer, W., Asero, R., Latiff, A. H. A., Baker, D. R., Ballmer-Weber, B. K., Bernstein, J. A., Bindslev‐Jensen, C., Brzoza, Z., Bedrikow, R. B., et al. (2018) · Allergy · doi:10.1111/all.13397 · Cited by 1,479 · see citing works
Zuberbier, T., Aberer, W., Asero, R., Bindslev‐Jensen, C., Brzoza, Z., Canonica, G. W., Church, M. K., Ensina, L. F., Giménez‐Arnau, A. M., Godse, K. V., et al. (2014) · Allergy · doi:10.1111/all.12313 · Cited by 1,206 · see citing works
The diagnosis and management of acute and chronic urticaria: 2014 update
Bernstein, J. A., Lang, D. M., Khan, D. A., Craig, T., Dreyfus, D. H., Hsieh, F. H., Sheikh, J. K., Weldon, D., Zuraw, B. L., Bernstein, D. I., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.02.036 · Cited by 685 · see citing works
The impact of chronic urticaria on the quality of life
O’Donnell, C. P., LAWLOR, F., SIMPSON, J., Morgan, M., & GREAVES, M. W. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.d01-1168.x · Cited by 615 · see citing works
Association of Schizophrenia and Autoimmune Diseases: Linkage of Danish National Registers
Eaton, W. W., Byrne, M., Ewald, H., Mors, O., Chen, C.-Y., Agerbo, E., & Mortensen, P. B. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.521 · Cited by 527 · see citing works
The impact of chronic urticaria on the quality of life
O’Donnell, B. F., Lawlor, F., SIMPSON, J., Morgan, M., & Greaves, M. W. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb14895.x · Cited by 465 · see citing works
Psychiatric morbidity in dermatological outpatients: an issue to be recognized
Picardi, A., Abeni, D., Melchi, C. F., Puddu, P., & Pasquini, P. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03831.x · Cited by 413 · see citing works
Recurrent urticaria: clinical investigation of 330 patients
JUHLIN, L. (1981) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1981.tb15306.x · Cited by 388 · see citing works
Neuroimmunoendocrine circuitry of the ‘brain-skin connection’
Paus, R., Theoharides, T. C., & Arck, P. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.10.002 · Cited by 346 · see citing works
Are some cases of psychosis caused by microbial agents? A review of the evidence
Yolken, R. H., & Torrey, E. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.5 · Cited by 327 · see citing works
Psychiatric morbidity in dermatological outpatients: an issue to be recognized
Aslam, R., Qadir, A., & Asad, F. (2016) · Journal of Pakistan Association of Dermatologists · doi:10.66344/jpad.v17i4.707 · Cited by 315 · see citing works
Losing your nerves? Maybe it's the antibodies
Diamond, B., Huerta, P. T., Mina-Osorio, P., Kowal, C., & Volpe, B. T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2529 · Cited by 247 · see citing works
Staubach, P., Eckhardt-Henn, A., Dechene, M., Vonend, A., Metz, M., Magerl, M., Breuer, P., & Maurer, M. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06976.x · Cited by 243 · see citing works
Dalman, C., Allebeck, P., Gunnell, D., Harrison, G. L., Kristensson, K., Lewis, G., Löfving, S., Rasmussen, F. E., Wicks, S., & Karlsson, H. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050740 · Cited by 242 · see citing works
Psychosomatic concepts in dermatology. A dermatologist-psychoanalyst's viewpoint
Koblenzer, C. S. (1983) · Archives of Dermatology · doi:10.1001/archderm.119.6.501 · Cited by 190 · see citing works
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
Maurer, M., Eyerich, K., Eyerich, S., Ferrer, M., Gutermuth, J., Hartmann, K., Jakob, T., Kapp, A., Kolkhir, P., Larenas‐Linnemann, D. E., et al. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000507218 · Cited by 186 · see citing works
Prevalence and correlates of suicidal ideation among patients with skin disease.
Picardi, A., Mazzotti, E., & Pasquini, P. (2006) · Journal of American Academy of Dermatology · doi:10.1016/j.jaad.2005.11.1103 · Cited by 179 · see citing works
Lapi, F., Cassano, N., Pegoraro, V., Cataldo, N., Heiman, F., Cricelli, I., Levi, M., Colombo, D., Zagni, E., Cricelli, C. A., et al. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14470 · Cited by 161 · see citing works
Jones, A. L., Mowry, B. J., Pender, M. P., & Greer, J. M. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01305.x · Cited by 155 · see citing works
Selected Infectious Agents and Risk of Schizophrenia Among U.S. Military Personnel
Niebuhr, D. W., Millikan, A. M., Cowan, D. N., Yolken, R. H., Li, Y., & Weber, N. S. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06081254 · Cited by 153 · see citing works
Staubach, P., Dechene, M., Metz, M., Magerl, M. A. K., Siebenhaar, F., Weller, K., Zezula, P., Eckhardt‐Henn, A., & Maurer, M. (2011) · Acta Dermato Venereologica · doi:10.2340/00015555-1109 · Cited by 147 · see citing works
The role of infection in the pathogenesis of autoimmune disease
Rose, N. R. (1998) · Seminars in Immunology · doi:10.1006/smim.1997.0100 · Cited by 131 · see citing works
Psychiatric Manifestations of Paraneoplastic Disorders
Kayser, M. S., Kohler, C. G., & Dalmau, J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101547 · Cited by 129 · see citing works
Psychiatric morbidity and quality of life in patients with chronic idiopathic urticaria
Özkan, M., Oflaz, S., Kocaman, N., Özşeker, F., Gelincik, A. A., Büyüköztürk, S., Özkan, S., & Çolakoğlu, B. (2007) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60617-5 · Cited by 119 · see citing works
Anxiety and depression in patients with chronic urticaria and generalized pruritus
LSHEEHAN-DARE, R. A., HENDERSON, M. J., & COTTERILL, J. A. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb04195.x · Cited by 109 · see citing works
The Problems in Sexual Functions of Vitiligo and Chronic Urticaria Patients
Sukan, M., & Maner, F. (2006) · Journal of Sex & Marital Therapy · doi:10.1080/00926230600998482 · Cited by 105 · see citing works
Perugi, G., Quaranta, G., Belletti, S., Casalini, F., Mosti, N., Toni, C., & Dell’Osso, L. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.08.052 · Cited by 104 · see citing works
Antibody-mediated encephalitis: a treatable cause of schizophrenia
Lennox, B., Coles, A. J., & Vincent, A. C. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.095042 · Cited by 97 · see citing works
Psychosocial factors and chronic spontaneous urticaria: a systematic review
Ben‐Shoshan, M., Blinderman, I., & Raz, A. (2013) · Allergy · doi:10.1111/all.12068 · Cited by 86 · see citing works
Higher Levels of Depression and Anxiety in Patients with Chronic Urticaria
Tat, T. S. (2019) · Medical Science Monitor · doi:10.12659/msm.912362 · Cited by 73 · see citing works
Stress, insomnia, and chronic idiopathic urticaria--a case-control study.
Yang, H., Sun, C. C., Wu, Y., & Wang, J. (2005) · PubMed · Cited by 71 · see citing works
Chu, C., Cho, Y., Jiang, J.-H., Lin, E. I.-C., & Tang, C. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.07.006 · Cited by 66 · see citing works
The relation of psychogenic excoriation with psychiatric disorders: a comparative study.
Çalıkuşu, C., Yücel, B., Polat, A., & Baykal, C. (2003) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(03)00041-5 · Cited by 65 · see citing works
Depression in adult dermatology outpatients.
Bashir, K., Dar, N. R., & Rao, S. U. (2010) · PubMed · Cited by 61 · see citing works
Huang, C., Yen, D. H.-T., Huang, H., Kao, W., Wang, L.-M., Huang, C., & Lee, C.-H. (2005) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70146-7 · Cited by 61 · see citing works
Gregoriou, S., Rigopoulos, D., Katsambas, A., Κατσαρού, Α., Papaioannou, D., Gkouvi, A., Kontochristopoulos, G., Danopoulou, I., Stavrianeas, N. G., & Kalogeromitros, D. (2009) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2008.08035 · Cited by 59 · see citing works
Hergüner, S., Kılıç, G., Karakoç, S., Tamay, Z., Tüzün, Ü., & Güler, N. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10138.x · Cited by 59 · see citing works
Chung, M. C., Symons, C., Gilliam, J., & Kaminski, E. R. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.02.005 · Cited by 58 · see citing works
Axis I and Axis II diagnoses in patients with chronic idiopathic urticaria
Uğuz, F., Engіn, B., & Yılmaz, E. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.08.006 · Cited by 53 · see citing works
Psychological Components and the Role of Adjunct Interventions in Chronic Idiopathic Urticaria
Sperber, J., Shaw, J. A., & Bruce, S. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288147 · Cited by 46 · see citing works
Sorour, F. A., Abdelmoaty, A. A., Bahary, M. H., & Birqdar, B. E. (2017) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000503397.22746.bd · Cited by 43 · see citing works
Potocka, A., Turczyn-Jabłońska, K., & Merecz, D. (2009) · PubMed · Cited by 40 · see citing works
Obsessive–compulsive disorder in a dermatology outpatient clinic
Demet, M. M., Deveci, A., Taskin, E. O., Ermertcan, A. T., Yurtsever, F., Deniz, F., Bayraktar, D., & Öztürkcan, S. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.04.006 · Cited by 34 · see citing works
Lindsay, K., Goulding, J., Solomon, M., & Broom, B. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0082-7 · Cited by 32 · see citing works
Gupta, M. A., & Gupta, A. K. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2012.01.012 · Cited by 31 · see citing works
Psychiatric morbidity in dermatology patients: Frequency and results of consultations
Seyhan, M., Akı, T., Karıncaoğlu, Y., & Özcan, H. (2006) · Indian Journal of Dermatology · doi:10.4103/0019-5154.25181 · Cited by 30 · see citing works
Psychiatric morbidity among dermatology inpatients.
Pulimood, S. A., Rajagopalan, B., Rajagopalan, M., Jacob, M., & John, J. K. (1996) · PubMed · Cited by 28 · see citing works
Gupta, M. A., & Gupta, A. K. (1995) · PubMed · Cited by 26 · see citing works
Dysthymic states and depressive syndromes in physical conditions of presumably psychogenic origin
Lyketsos, C. G., Lyketsos, G. C., Richardson, S. C., & Beis, A. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02914.x · Cited by 25 · see citing works
Zur Beziehung zwischen chronischer Urtikaria und Depression/ Somatisierungsstörung
Hein, U. R., Henz, B. M., Haustein, U. F., Seikowski, K., Aberer, W., Lautenschlager, S., & Klapp, B. F. (1996) · Der Hautarzt · doi:10.1007/s001050050369 · Cited by 23 · see citing works
A Cohort Study of the Relationship Between Anger and Chronic Spontaneous Urticaria
Altınöz, A. E., Taşkıntuna, N., Altınöz, Ş. T., & Ceran, S. (2014) · Advances in Therapy · doi:10.1007/s12325-014-0152-6 · Cited by 23 · see citing works
A reappraisal of the role of ‘mindbody’ factors in chronic urticaria
Broom, B. (2010) · Postgraduate Medical Journal · doi:10.1136/pgmj.2009.096446 · Cited by 20 · see citing works
Skin and brain: itch and psychiatric disorders.
Caccavale, S., Bove, D., Bove, R. M., & Montagna, M. L. (2016) · PubMed · Cited by 17 · see citing works
Kuo, C., Chen, C. Y., Huang, H. L., Chen, W., Lee, H. C., Chang, C.-Y., Chou, C.-C., Ho, S., Wu, H. P., & Lin, Y. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-181 · Cited by 16 · see citing works
Psychosomatic Treatment of a Case of Chronic Urticaria
Hashiro, M. (1995) · The Journal of Dermatology · doi:10.1111/j.1346-8138.1995.tb03899.x · Cited by 10 · see citing works
[Psychological factors in chronic urticaria].
Sg, C. (2003) · PubMed · Cited by 8 · see citing works
Is There an Association between Restless Legs Syndrome and Urticaria?
Tuna, S., Alan, S., Samancı, N., & Karakaş, A. A. (2016) · Journal of Korean Medical Science · doi:10.3346/jkms.2016.31.5.790 · Cited by 7 · see citing works
The role of allergy in neuropsychiatry
Clarke, T. W. (1940) · Psychiatric Quarterly · doi:10.1007/bf01566798 · Cited by 2 · see citing works
Psychological Status in Patients with Chronic Urticaria
Peyghambari, S., Rahimi, M., Atefi, N., & Ghourchian, S. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2 · see citing works
[Mental disorders in patients suffering from allergy].
Czubalski, K. (1972) · PubMed · Cited by 1 · see citing works
[Neuropsychological findings in chronic urticaria].
Drunkenmölle, R. (1971) · PubMed · Cited by 1 · see citing works
Psychosomatic Concepts in Dermatology
Koblenzer, C. S. (1983) · Archives of Dermatology · doi:10.1001/archderm.1983.01650300055017
Flagged first, then by citations
Cited by
Sorted by citations
The global burden of chronic urticaria for the patient and society*
Gonçalo, M., Giménez-Arnau, A. M., Al-Ahmad, M. S., Ben‐Shoshan, M., Bernstein, J. A., Ensina, L. F., Fomina, D. S., Galván, C. A., Godse, K. V., Grattan, C. E. H., et al. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19561 · Cited by 387 · see citing works
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
Maurer, M., Eyerich, K., Eyerich, S., Ferrer, M., Gutermuth, J., Hartmann, K., Jakob, T., Kapp, A., Kolkhir, P., Larenas‐Linnemann, D. E., et al. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000507218 · Cited by 186 · see citing works
Predictors of treatment response in chronic spontaneous urticaria
Fok, J. S., Kolkhir, P., Church, M. K., & Maurer, M. (2021) · Allergy · doi:10.1111/all.14757 · Cited by 164 · see citing works
Kolkhir, P., Bonnekoh, H., Metz, M., & Maurer, M. (2024) · JAMA · doi:10.1001/jama.2024.15568 · Cited by 156 · see citing works
Sánchez‐Borges, M., Ansotegui, I. J., Baiardini, I., Bernstein, J., Canonica, G. W., Ebisawa, M., Gómez, M. R., Díaz, S. N. G., Martin, B. L., Morais‐Almeida, M., et al. (2021) · World Allergy Organization Journal · doi:10.1016/j.waojou.2021.100533 · Cited by 138 · see citing works
Weller, K., Maurer, M., Bauer, A., Wedi, B., Wagner, N., Schliemann, S., Kramps, T., Baeumer, D., Multmeier, J., Hillmann, E., et al. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17724 · Cited by 64 · see citing works
Hawro, T., Przybyłowicz, K., Spindler, M., Hawro, M., Steć, M., Altrichter, S., Weller, K., Magerl, M. A. K., Reidel, U., Alarbeed, E., et al. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.08.035 · Cited by 59 · see citing works
Konstantinou, G. N., & Konstantinou, G. N. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.03.010 · Cited by 58 · see citing works
Allergic Diseases and Mental Health
Conway, A. E., Verdi, M., Kartha, N., Maddukuri, C., Anagnostou, A., Abrams, E. M., Bansal, P., Bukstein, D. A., Nowak-Wegrzyn, A. H., Oppenheimer, J. J., et al. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.05.049 · Cited by 55 · see citing works
The Diagnostic Workup in Chronic Spontaneous Urticaria—What to Test and Why
Metz, M., Altrichter, S., Buttgereit, T., Fluhr, J. W., Fok, J. S., Hawro, T., Jiao, Q., Kolkhir, P., Krause, K., Magerl, M. A. K., et al. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.03.049 · Cited by 52 · see citing works
Konstantinou, G. Ν., Konstantinou, G., Koulias, C., Petalas, K., & Makris, M. P. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s282039 · Cited by 50 · see citing works
Bitan, D. T., Berzin, D., & Cohen, A. D. (2020) · Archives of Dermatological Research · doi:10.1007/s00403-020-02064-3 · Cited by 51 · see citing works
Jalenques, I., Bourlot, F., Martinez, E., Pereira, B., D'Incan, M., Lauron, S., & Rondepierre, F. (2022) · Acta Dermato Venereologica · doi:10.2340/actadv.v102.1386 · Cited by 45 · see citing works
Comorbidities of Chronic Urticaria: A glimpse into a complex relationship
Papapostolou, N., Xepapadaki, P. V., Katoulis, A., & Makris, M. P. (2022) · Frontiers in Allergy · doi:10.3389/falgy.2022.1008145 · Cited by 38 · see citing works
Association of Chronic Urticaria with Psychological Distress: A Multicentre Cross-sectional Study
Tawil, S., Irani, C., Kfoury, R., Abramian, S., Salameh, P., Weller, K., Maurer, M., & Ezzedine, K. (2022) · Acta Dermato Venereologica · doi:10.2340/actadv.v102.2939 · Cited by 30 · see citing works
Yang, S., Chen, L., Zhang, H., Song, Y., Wang, W., Hu, Z., Wang, S., Huang, L., Wang, Y., Wu, S., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03397-4 · Cited by 32 · see citing works
Konstantinou, G. Ν., Riedl, M. A., Valent, P., Podder, I., & Maurer, M. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.11.006 · Cited by 28 · see citing works
Ozdemir, S. O., Can, P. K., Değirmentepe, E. N., Cure, K., Singer, R., & Kocatürk, E. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19637 · Cited by 27 · see citing works
Mortality in adult patients with chronic spontaneous urticaria: A real-world cohort study
Kolkhir, P., Bieber, K., Hawro, T., Kridin, K., Ludwig, M. A., Olbrich, H., Metz, M., Vorobyev, A., Ludwig, R. J., & Maurer, M. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.11.036 · Cited by 27 · see citing works
Jalenques, I., Lauron, S., Almon, S., Pereira, B., D'Incan, M., & Rondepierre, F. (2020) · Acta Dermato Venereologica · doi:10.2340/00015555-3660 · Cited by 26 · see citing works
Ansotegui, I. J., Bernstein, J. A., Canonica, G. W., Díaz, S. N. G., Martin, B. L., Morais‐Almeida, M., Murrieta‐Aguttes, M., & Borges, M. S. (2022) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-022-00677-z · Cited by 24 · see citing works
Expert consensus on practical aspects in the treatment of chronic urticaria
Bauer, A., Dickel, H., Jakob, T., Kleinheinz, A., Lippert, U., Metz, M., Schliemann, S., Schwichtenberg, U., Staubach, P., Valesky, E. M., et al. (2021) · Allergo Journal International · doi:10.1007/s40629-021-00162-w · Cited by 23 · see citing works
Clinical review: The suggested management pathway for urticaria in primary care
Ryan, D. P., Tanno, L. K., Angier, E., Clark, E., Price, D. B., Zuberbier, T., & Maurer, M. (2022) · Clinical and Translational Allergy · doi:10.1002/clt2.12195 · Cited by 21 · see citing works
Hawkins, B., Montgomery, M., Bokota, G., Santoyo, M., Giron, E., & Eltokhi, A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2574934 · Cited by 22 · see citing works
Memet, B., Vurgun, E., Barlas, F., Metz, M., Maurer, M., & Kocatürk, E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.667978 · Cited by 20 · see citing works
Tayefi, M., Bradley, M., Neijber, A., Fastberg, A., Ceynowa, D., & Eriksson, M. (2021) · Acta Dermato Venereologica · doi:10.2340/actadv.v101.737 · Cited by 18 · see citing works
Keller, J. J. (2023) · Archives of Dermatological Research · doi:10.1007/s00403-023-02542-4 · Cited by 18 · see citing works
Highlights and recent developments in allergic diseases in EAACI journals (2019)
Bousquet, J., Grattan, C. E. H., Akdiş, C. A., Eigenmann, P., Hoffmann‐Sommergruber, K., Agache, I. O., & Jutel, M. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00366-3 · Cited by 18 · see citing works
Psychological burden of COVID-19 on mild and moderate chronic spontaneous urticaria
Beyaz, Ş., Demir, S., Öztop, N., Karadağ, P., Coşkun, R., Çolakoğlu, B., Büyüköztürk, S., & Gelincik, A. A. (2021) · Allergy and Asthma Proceedings · doi:10.2500/aap.2021.42.210026 · Cited by 17 · see citing works
Psychological Stress and Urticaria: Pathophysiologic and Therapeutic Updates
Xiang, Y., Türk, M., Chérrez-Ojeda, I., Komi, D. E. A., Salman, A., & Kocatürk, E. (2024) · Current Treatment Options in Allergy · doi:10.1007/s40521-024-00375-8 · Cited by 17 · see citing works
Highlights and recent developments in airway diseases in EAACI journals (2017)
Bousquet, J., Akdiş, C. A., Grattan, C. E. H., Eigenmann, P., Hoffmann‐Sommergruber, K., Hellings, P. W., & Agache, I. O. (2018) · Clinical and Translational Allergy · doi:10.1186/s13601-018-0238-3 · Cited by 15 · see citing works
Keller, L., & Stitt, J. M. (2024) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2024.03.004 · Cited by 14 · see citing works
Impact of allergic reactions and urticaria on mental health and quality of life
Stadler, P., Marsela, E., Kämmerer, T. A., Frommherz, L. H., Clanner-Engelshofen, B. M., French, L. E., Oppel, E. M., & Reinholz, M. (2022) · Allergologia et Immunopathologia · doi:10.15586/aei.v50i2.525 · Cited by 13 · see citing works
Tawil, S., Irani, C., Kfoury, R., Salameh, P., Baiardini, I., Weller, K., Maurer, M., & Ezzedine, K. (2020) · International Journal of Dermatology · doi:10.1111/ijd.15006 · Cited by 12 · see citing works
Can, P. K., Etikan, P., Değirmentepe, E. N., & Kocatürk, E. (2021) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-180920-0965 · Cited by 14 · see citing works
Ridge, K., Conlon, N. P., Hennessy, M., & Dunne, P. J. (2021) · Pilot and Feasibility Studies · doi:10.1186/s40814-021-00841-z · Cited by 11 · see citing works
Yong, S.-S., Robinson, S., Kwan, Z., Khoo, E., Han, W., Tan, L., Wong, S.-M., & Tang, M.-M. (2022) · Psychology, Health & Medicine · doi:10.1080/13548506.2022.2029914 · Cited by 9 · see citing works
Psychiatric comorbidities in children and adolescents with chronic urticaria
Konstantinou, G. Ν., & Konstantinou, G. (2022) · World Journal of Pediatrics · doi:10.1007/s12519-022-00641-2 · Cited by 11 · see citing works
Pediatric chronic urticaria: Clinical and laboratory characteristics and factors linked to remission
Sandoval, M., Domínguez, O., de Landazuri, I. O., Gereda, D., Cisneros, M. E., Quesada-Sequeira, F., Rodríguez, S. M. R., Machinena, A., Piquer, M., Folqué, M. D. M., et al. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.13929 · Cited by 11 · see citing works
Qian, J., He, M., Zhan, X., Ren, L., & Sun, Q. (2022) · Geriatric Nursing · doi:10.1016/j.gerinurse.2022.12.010 · Cited by 10 · see citing works
Occurrence and risk factors of mental disorders in patients with chronic urticaria
Ghazanfar, M. N., Sørensen, J. A., Zhang, D. G., Holgersen, N. K., Vestergaard, C., & Thomsen, S. F. (2023) · World Allergy Organization Journal · doi:10.1016/j.waojou.2023.100835 · Cited by 9 · see citing works
Schielein, M. C., Tizek, L., Baeumer, D., Hillmann, E., Romer, K., Wagner, N., & Zink, A. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15740 · Cited by 9 · see citing works
Chernyshov, P. V., Finlay, A. Y., Tomas‐Aragones, L., Zuberbier, T., Kocatürk, E., Manolache, L., Pustišek, N., Svensson, Å., Marrón, S. E., Sampogna, F., et al. (2024) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.20157 · Cited by 8 · see citing works
Hindelang, M., Sitaru, S., Fischer, C., Biedermann, T., & Zink, A. (2025) · JDDG: Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15557 · Cited by 7 · see citing works
Managing Chronic Urticaria in Children: An Update
Ensina, L. F., Brandão, L. S., Netchiporouk, E., & Ben‐Shoshan, M. (2025) · Current Allergy and Asthma Reports · doi:10.1007/s11882-025-01202-z · Cited by 6 · see citing works
Lugović‐Mihić, L., Štrajtenberger, M., Kuna, M., Davidović, B. L., Barac, E., & Vilibić, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110384 · Cited by 6 · see citing works
Characterization of Chronic Urticaria and Associated Conditions - A Web-Based Survey
Zysk, W., & Trzeciak, M. (2023) · Dermatology Practical & Conceptual · doi:10.5826/dpc.1301a56 · Cited by 6 · see citing works
Cognitive Impairment and Depression in Mastocytosis: A Synthesis of the Literature
Nicoloro‐SantaBarbara, J. M., Majd, M., Burdick, K. E., Dixon, V., & Giannetti, M. P. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01127-z · Cited by 6 · see citing works
Ferdous, S., Rajasegaran, R., Munisamy, M., Basu, S., & Harichandrakumar, K. T. (2023) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_648_22 · Cited by 5 · see citing works
The role of childhood trauma in patients with chronic urticaria
Cansel, N. (2021) · Northern Clinics of Istanbul · doi:10.14744/nci.2021.10170 · Cited by 5 · see citing works
Internalized stigma in chronic urticaria: A case–control study
Temel, A. B., Özdemir, A., Can, P. K., Koyuncu, M. A., Dönmez, L., Karakaş, A. A., Kocatürk, E., & Alpsoy, E. (2022) · Australasian Journal of Dermatology · doi:10.1111/ajd.13889 · Cited by 5 · see citing works
Akdaş, E., Gülekon, A., Bulut, T. S. D., Gülbahar, Ö., Öztürk, M., Başaran, A. S., & Çoşar, B. (2024) · Allergologia et Immunopathologia · doi:10.15586/aei.v52i3.1015 · Cited by 5 · see citing works
Konstantinou, G. Ν., Podder, I., & Konstantinou, G. (2025) · Cureus · doi:10.7759/cureus.81443 · Cited by 5 · see citing works
The use of SCL-k-9 to measure general psychopathology in women and men with skin conditions
Samela, T., Cordella, G., Antinone, V., Sarandrea, P., Giampetruzzi, A. R., & ABENI, D. D. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.977264 · Cited by 4 · see citing works
Chérrez-Ojeda, I., Thomsen, S. F., & Giménez‐Arnau, A. M. (2023) · British Journal of Dermatology · doi:10.1093/bjd/ljad272 · Cited by 4 · see citing works
Psychophysiological disorders and the skin
Carniciu, S., & Jafferany, M. (2023) · Dermatological Reviews · doi:10.1002/der2.205 · Cited by 4 · see citing works
Bešlić, I. (2023) · Acta Clinica Croatica · doi:10.20471/acc.2023.62.02.17 · Cited by 4 · see citing works
Zhang, H., Xiang, W., Tong, Y., Jiang, X., & Guo, L. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09115-5 · Cited by 4 · see citing works
Stolz, J., Salameh, P., Asero, R., Kocatürk, E., Peter, J., Grattan, C. E. H., Herzog, L. S., Muñoz, M., Dissemond, J., Staubach, P., et al. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.05.033 · Cited by 3 · see citing works
Xiao, M., Zhang, X., Guo, A., Zhang, K., Zhao, Q., Fan, L., Xue, L., Zhang, J., Hou, S., & Wang, H. (2024) · Acta Dermato Venereologica · doi:10.2340/actadv.v104.24050 · Cited by 3 · see citing works
Liu, Z., Wang, Y., Wang, S., Wu, J., Cui, J., Tan, X., Liu, X., Huang, X., & Zhang, L. (2024) · Skin Research and Technology · doi:10.1111/srt.13906 · Cited by 2 · see citing works
RetractedGotua, M., Agondi, R. C., & Chérrez-Ojeda, I. (2022) · Indian Journal of Skin Allergy · doi:10.25259/ijsa_5_2022 · Cited by 3 · see citing works
Alotaibi, H., Alghamdi, A. S., Almutairi, R. T., Altamimi, R. M., & Osailan, R. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-03613-w · Cited by 2 · see citing works
Li, X., Wang, X., Zhu, L., Liu, J., Wang, J., & Chen, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.112 · Cited by 2 · see citing works
Kumaran, M. S., Kaur, S., Parsad, D., & Narang, T. K. (2025) · Indian Dermatology Online Journal · doi:10.4103/idoj.idoj_415_25 · Cited by 2 · see citing works
Balp, M., Pivneva, I., Danyliv, A., Chen, K., Cornwall, T., Royer, J., Signorovitch, J., Patil, D., Kohli, R. K., Severin, T. M., et al. (2025) · Dermatology and Therapy · doi:10.1007/s13555-025-01376-4 · Cited by 2 · see citing works
Chérrez-Ojeda, I., Thomsen, S. F., Giménez‐Arnau, A. M., Sørensen, J. A., Lima, H., Godse, K. V., Guillet, C., Escalante, L., Maldonado, A., Chorzepa, G. F., et al. (2025) · Clinical and Translational Allergy · doi:10.1002/clt2.70075 · Cited by 2 · see citing works
Expertenkonsensus zu praxisrelevanten Aspekten bei der Behandlung der chronischen Urtikaria
Bauer, A., Dickel, H., Jakob, T., Kleinheinz, A., Lippert, U., Metz, M., Schliemann, S., Schwichtenberg, U., Staubach, P., Valesky, E. M., et al. (2021) · Allergo Journal · doi:10.1007/s15007-021-4772-2 · Cited by 2 · see citing works
A Meta-Analysis of Randomized Clinical Trials of Runzao Zhiyang Capsule in Chronic Urticaria
Ye, S., Zhang, X., Ling, G., Xiao, X., Huang, D. F., & Chen, M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1904598 · Cited by 2 · see citing works
Chuamanochan, M., & Nochaiwong, S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0279566 · Cited by 2 · see citing works
Modern Approaches to the Management of Patients with Urticaria
Aa, B., Namazova-Baranova, L. S., Ивановна, И. Н., Kubanov, A. A., Araviyskaya, E. R., Astafieva, N. G., Базаев, В. Т., Borzova, E. Y., Vishneva, Е. A., Gallyamova, Y. A., et al. (2023) · Педиатрическая фармакология · doi:10.15690/pf.v20i5.2629 · Cited by 1 · see citing works
The Incidence of Addiction and Its Risk Factors in Chinese Chronic Urticaria Patients
Shui, X., Jiang, Y. L., Peng, C., Cao, Q., & Li, J. (2025) · Clinical & Experimental Allergy · doi:10.1111/cea.70151 · Cited by 1 · see citing works
Lin, S., & Yao, X. (2025) · ALPHA PSYCHIATRY · doi:10.31083/ap47646 · Cited by 1 · see citing works
Bešlić, I., Vrtarić, A., Škrinjar, I., Barac, E., Vodanović, A. K., & Lugović‐Mihić, L. (2026) · Clinics and Practice · doi:10.3390/clinpract16020036 · Cited by 1 · see citing works
Bupropion-induced early-onset urticaria
Saini, V. K., Raj, A. B., & Tyagi, S. (2026) · BMJ Case Reports · doi:10.1136/bcr-2026-273117 · Cited by 1 · see citing works
The Quality of Life in Patients with Chronic Urticaria
yousif, S. Z., & Yaaqub, P. Y. (2022) · Annals of the College of Medicine Mosul/Annals of the College of Medecine · doi:10.33899/mmed.2022.133449.1142 · Cited by 1 · see citing works
Welche Augmentations- und Triggerfaktoren sind bei der Urtikaria relevant?
Zarnowski, J., & Treudler, R. (2024) · Die Dermatologie · doi:10.1007/s00105-024-05306-x · Cited by 1 · see citing works
Chronic Urticaria Through the Prism of Psycho-Neuro-Immunology: Another “Gordian Knot” to Solve
Konstantinou, G., & Konstantinou, G. Ν. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_23 · Cited by 1 · see citing works
Impact of Chronic Urticaria and How to Measure It
Weller, K. (2021) · Springer eBooks · doi:10.1007/978-3-030-84574-2_4 · Cited by 1 · see citing works
Could distress tolerance levels be associated with the severity of chronic spontaneous urticaria?
Göçer Gürok, N., Gürok, M. G., & Öztürk, S. (2022) · TURKDERM · doi:10.4274/turkderm.galenos.2022.46793
Urticaria solar: una entidad infrecuente con gran impacto en la calidad de vida. Reporte de un caso
Castillo, D. M. M., Abreu, S., Guevara-Saldaña, L. M., & Villa, R. C. (2021) · Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica · doi:10.29176/2590843x.1626
Other Interventions for Chronic Urticaria
Grattan, C. E. H., Zuberbier, T., & Maurer, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-84574-2_13
Chronic spontaneous urticaria or urticarial vasculitis?
Dorofeeva, I. V., Danilycheva, I. V., & Евгеньевич, Ш. А. (2021) · Russian Journal of Allergy · doi:10.36691/rja1494
Telia, Z., Machavariani, K., TELIA, A. Z., & TELIA, A. Z. (2022) · EXPERIMENTAL & CLINICAL MEDICINE GEORGIA · doi:10.52340/jecm.2022.07.19
The effect of stress on the onset of chronic spontaneous urticaria in the elderly
Öztop, N., & Beyaz, Ş. (2023) · Alergologia Polska - Polish Journal of Allergology · doi:10.5114/pja.2023.125769
Update on prospective markers of treatment response with omalizumab in chronic spontaneous urticaria
Corcea, S.-L., Bumbăcea, R. S., Ali, S., & Coman, O.-A. (2023) · Alergologia · doi:10.26416/aler.7.2.2023.8194
A case -control study on the effect of alexithymia in patients of chronic urticarial
Godse, K. V., Ansari, H., Maganbhai, B. A., Gurjar, N., & Patil, S. P. (2023) · IP Indian Journal of Clinical and Experimental Dermatology · doi:10.18231/j.ijced.2023.027
Dermatolojik Hastalıklara Algoritmik Yaklaşım ve Tanısal İpuçları
Yavuz, C., Durdu, M., Yorulmaz, A., Günaydın, S. D., Çınar, S. L., Kızıltaç, K., Kocatürk, E., Hacınecipoğlu, F., Gönül, M., Çakmak, S. K., et al. (2022) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.1231
Grattan, C. E. H., & Sears, A. V. (2024) · doi:10.1002/9781119709268.rook042
Hindelang, M., Sitaru, S., Fischer, C., Biedermann, T., & Zink, A. (2025) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15557_g
Can, P. K., & Can, U. (2025) · Dermatology Practical & Conceptual · doi:10.5826/dpc.1501a4470
Zakaraya, D. (2025) · Egyptian journal of Immunology · doi:10.55133/eji.320212
de Souza, A. P. F. A., Bertoli, A. F., Pacheco, M. A., Martini, A. P. S., Crivelatti, I., & da Silva, J. (2024) · Arquivos Catarinenses de Medicina · doi:10.63845/wws86s38
Ligelizumab use for chronic spontaneous urticaria
Osborne, S., Vo, C., Thacker, S., Wescott, R., & Wu, J. J. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01223-1
Lupus cutané, dépression et anxiété
Jalenques, I., & Rondepierre, F. (2025) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2025.04.025
Resposta ao tratamento na urticária crônica: análise de preditores clínico‐laboratoriais
da Fonseca, J. T., de Figueiredo, J. P., Neves, L. V. B. T., de Oliveira, J. C. S., de Oliveira, J. S., Figueiredo, V. R., & Campos, R. A. (2026) · Anais Brasileiros de Dermatologia (Versão em Português) · doi:10.1016/j.abdp.2025.501261
Treatment response in chronic urticaria: analysis of clinical and laboratory predictors
da Fonseca, J. T., de Figueiredo, J. P., Neves, L. V. B. T., de Oliveira, J. C. S., de Oliveira, J. S., Figueiredo, V. R., & Campos, R. A. (2026) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2025.501261
Yeşilkaya, S. (2026) · Anatolian Current Medical Journal · doi:10.38053/acmj.1860417
- Authors
- Konstantinou, G. N., & Konstantinou, G. N.
- Affiliations
- Hellenic Air Force (GR)
- Venue
- Clinical and Translational Allergy
- Publisher
- Wiley
- Published
- 2019-08-23
- Volume
- 9
- Issue
- 1
- Pages
- 42-42
- ISSN
- 2045-7022 (ISSN-L)
- PMC
- PMC6706894
- OpenAlex
- W2969929864
- Cited by
- 110
- References
- 66
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 9 · 2018: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical and Translational Allergy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- chronic urticaria, psychiatric comorbidity, mental illness, depression, anxiety, antidepressants, anxiolytics, psychological intervention, urticaria severity, multidisciplinary care
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