The association between attention deficit hyperactivity disorder and general anaesthesia ‐ a narrative review
Abstract
Summary: Attention deficit hyperactivity disorder is a chronic neurodevelopmental disorder, manifesting primarily as attention deficit, hyperactivity and impulsive behaviour. General anaesthetics can be neurotoxic, affecting neuronal differentiation and synaptogenesis, which can lead to abnormalities of cognition, learning and behaviour. We hypothesise that exposure of the immature brain to general anaesthetics predisposes to the development of attention deficit hyperactivity disorder. In this review, we summarise clinical and animal studies that relate attention deficit hyperactivity disorder to general anaesthesia, by actions on neural molecular mechanisms and neural networks. We also describe potential therapeutic approaches to modulate these effects.
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BDNF has a relevant role in synaptogenesis regulation and stimulates neuronal development and maintenance.
“BDNF has a relevant role in synaptogenesis regulation and stimulates neuronal development and maintenance [122, 217].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [217]
Cites
Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies
Cortese, S., Kelly, C., Chabernaud, C., Proal, E., Di Martino, A., Milham, M. P., & Castellanos, F. X. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11101521 · Cited by 1,067 · cited 1× · see citing works
“Patients with ADHD exhibit impaired neuronal activity in the prefrontal cortex and the frontal lobe-striatum loop [47].”
BackgroundSun, L. S., Li, G., Miller, T. L. K., Salorio, C., Byrne, M. W., Bellinger, D. C., Ing, C., Park, R., Radcliffe, J., Hays, S. R., et al. (2016) · JAMA · doi:10.1001/jama.2016.6967 · Cited by 949 · see citing works
Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications
Volkow, N. D., Wang, G.-J., Kollins, S. H., Wigal, T. L., Newcorn, J. H., Telang, F., Fowler, J. S., Zhu, W., Logan, J., Ma, Y., et al. (2009) · JAMA · doi:10.1001/jama.2009.1308 · Cited by 728 · cited 1× · see citing works
“Adult patients with untreated ADHD have defects in dopaminergic transmission in the substantia nigra, especially in the density of postsynaptic D2 and D3 receptor subtypes, the function of which might be improved by benzedrine, a dopamine receptor agonist [25, 26].”
BackgroundSelimbeyoglu, A., Kim, C. K., Inoue, M., Lee, S. Y., Hong, A. S. O., Kauvar, I., Ramakrishnan, C., Fenno, L. E., Davidson, T. J., Wright, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah6733 · Cited by 326 · see citing works
Stress effects on BDNF expression: Effects of age, sex, and form of stress
Bath, K. G., Schilit, A., & Lee, F. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.074 · Cited by 197 · see citing works
Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine
Kim, I. H., Rossi, M. A., Aryal, D. K., Racz, B., Kim, N., Uezu, A., Wang, F., Wetsel, W. C., Weinberg, R. J., Yin, H., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4015 · Cited by 127 · see citing works
Disruption of corticocortical information transfer during ketamine anesthesia in the primate brain
Schroeder, K. E., Irwin, Z. T., Gaidica, M., Bentley, J. N., Patil, P. G., Mashour, G. A., & Chestek, C. A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.039 · Cited by 95 · see citing works
Prenatal ketamine exposure causes abnormal development of prefrontal cortex in rat
Zhao, T., Li, C., Wei, W., Zhang, H., Ma, D., Song, X., & Zhou, L. (2016) · Scientific Reports · doi:10.1038/srep26865 · Cited by 59 · see citing works
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Quintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00392-2 · Cited by 70 · see citing works
“BDNF has a relevant role in synaptogenesis regulation and stimulates neuronal development and maintenance [122, 217].”
Background
- Authors
- Xu, L., Hu, Y., Huang, L., Liu, Y., Wang, B., Xie, L., & Hu, Z.
- Affiliations
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Yale University (US)
- Children's Hospital of Zhejiang University (CN)
- Venue
- Anaesthesia
- Publisher
- Wiley
- Published
- 2018-11-22
- Volume
- 74
- Issue
- 1
- Pages
- 57-63
- ISSN
- 0003-2409 (ISSN-L)
- 1365-2044
- OpenAlex
- W2903418717
- Cited by
- 20
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anaesthesia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81400929, 81471240, 81641042, 81603545)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- attention deficit hyperactivity disorder, general anesthesia, neurotoxicity, neurodevelopmental disorders, synaptogenesis, artificial neural networks, molecular mechanisms, neuroprotection
- MeSH terms
- Adult, Anesthesia, General, Animals, Attention Deficit Disorder with Hyperactivity, Brain, Child, Humans, Anesthetics, General
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