Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine
Open accessAbstract
Psychiatric and neurodevelopmental disorders may arise from anomalies in long-range neuronal connectivity downstream of pathologies in dendritic spines. However, the mechanisms that may link spine pathology to circuit abnormalities relevant to atypical behavior remain unknown. Using a mouse model to conditionally disrupt a critical regulator of the dendritic spine cytoskeleton, the actin-related protein 2/3 complex (Arp2/3), we report here a molecular mechanism that unexpectedly reveals the inter-relationship of progressive spine pruning, elevated frontal cortical excitation of pyramidal neurons and striatal hyperdopaminergia in a cortical-to-midbrain circuit abnormality. The main symptomatic manifestations of this circuit abnormality are psychomotor agitation and stereotypical behaviors, which are relieved by antipsychotics. Moreover, this antipsychotic-responsive locomotion can be mimicked in wild-type mice by optogenetic activation of this circuit. Collectively these results reveal molecular and neural-circuit mechanisms, illustrating how diverse pathologies may converge to drive behaviors relevant to psychiatric disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Abnormally elevated excitation in cortical pyramidal neurons may lead to striatal hyperdopaminergia in mice.
“Consistent with this idea, abnormally elevated excitation in cortical pyramidal neurons may lead to striatal hyperdopaminergia in mice 64 ,”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [64]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454 · see citing works
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
Ungerstedt, U., & Arbuthnott, G. W. (1970) · Brain Research · doi:10.1016/0006-8993(70)90187-3 · Cited by 1,993 · see citing works
Insel, T. R. (2010) · Nature · doi:10.1038/nature09552 · Cited by 1,783 · see citing works
De novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617 · see citing works
Dendritic spine pathology in neuropsychiatric disorders
Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523 · see citing works
A polygenic burden of rare disruptive mutations in schizophrenia
Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O’Dushlaine, C., Chambert, K., Bergen, S. E., Kähler, A., et al. (2014) · Nature · doi:10.1038/nature12975 · Cited by 1,385 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81826-7 · Cited by 1,280 · see citing works
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
Watabe‐Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., & Uchida, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.017 · Cited by 1,221 · see citing works
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia
Mohn, A. R., Gainetdinov, R. R., Caron, M. G., & Koller, B. H. (1999) · Cell · doi:10.1016/s0092-8674(00)81972-8 · Cited by 1,075 · see citing works
SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction
Ke, M., Fujimoto, S., & Imai, T. (2013) · Nature Neuroscience · doi:10.1038/nn.3447 · Cited by 895 · see citing works
CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854 · see citing works
Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.154 · Cited by 844 · see citing works
Sesack, S. R., & Pickel, V. M. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903200202 · Cited by 820 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice
Meng, Y., Zhang, Y., Tregoubov, V., Janus, C., Cruz, L., Jackson, M., Lu, W.-Y., MacDonald, J. F., Wang, J. Y., Falls, D. L., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00758-4 · Cited by 688 · see citing works
Dendritic spine pathology in schizophrenia
Glausier, J. R., & Lewis, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.044 · Cited by 581 · see citing works
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), Lee, S. H., The International Schizophrenia Consortium (ISC), The Molecular Genetics of Schizophrenia Collaboration (MGS), DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., Keller, M. C., et al. (2012) · Nature Genetics · doi:10.1038/ng.1108 · Cited by 579 · see citing works
Lawrie, S. M., Buechel, C., Whalley, H. C., Frith, C. D., Friston, K. J., & Johnstone, E. C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01316-1 · Cited by 529 · see citing works
Spine neck plasticity regulates compartmentalization of synapses
Tønnesen, J., Katona, G., Rózsa, B., & Nägerl, U. V. (2014) · Nature Neuroscience · doi:10.1038/nn.3682 · Cited by 444 · see citing works
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2487 · Cited by 399 · see citing works
Clement, J. P., Aceti, M., Creson, T. K., Ozkan, E. D., Shi, Y., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.045 · Cited by 385 · see citing works
Molecular mechanisms of dendrite stability
Koleske, A. J. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3486 · Cited by 351 · see citing works
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
Han, K., Holder, J. L., Schaaf, C. P., Lu, H., Chen, H., Kang, H., Tang, J., Wu, Z., Hao, S., Cheung, S. W., et al. (2013) · Nature · doi:10.1038/nature12630 · Cited by 351 · see citing works
van den Buuse, M. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp132 · Cited by 340 · see citing works
Reduced communication between frontal and temporal lobes during talking in schizophrenia
Ford, J. M., Mathalon, D. H., Whitfield‐Gabrieli, S., Faustman, W. O., & Roth, W. T. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01335-x · Cited by 332 · see citing works
Durand, C. M., Perroy, J., Loll, F., Perrais, D., Fagni, L., Bourgeron, T., Montcouquiol, M., & Sans, N. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.57 · Cited by 316 · see citing works
Progressive brain structural changes mapped as psychosis develops in ‘at risk’ individuals
Sun, D., Phillips, L., Velakoulis, D., Yung, A. R., McGorry, P. D., Wood, S. J., van Erp, T. G. M., Thompson, P. M., Toga, A. W., Cannon, T. D., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.026 · Cited by 296 · see citing works
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296 · see citing works
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
Govek, E.-E., Newey, S. E., Akerman, C. J., Cross, J. R., Van der Veken, L., & Van Aelst, L. (2004) · Nature Neuroscience · doi:10.1038/nn1210 · Cited by 293 · see citing works
Synaptic amplification by dendritic spines enhances input cooperativity
Harnett, M. T., Makara, J. K., Spruston, N., Kath, W. L., & Magee, J. C. (2012) · Nature · doi:10.1038/nature11554 · Cited by 288 · see citing works
Dorsolateral Prefrontal Cortex Drives Mesolimbic Dopaminergic Regions to Initiate Motivated Behavior
Ballard, I. C., Murty, V. P., Carter, R. M., MacInnes, J., Huettel, S. A., & Adcock, R. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0895-11.2011 · Cited by 284 · see citing works
Structure, Subunit Topology, and Actin-binding Activity of the Arp2/3 Complex from Acanthamoeba
Mullins, R. D., Stafford, W. F., & Pollard, T. D. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.2.331 · Cited by 227 · see citing works
Hoffman, D., & Donovan, H. (1995) · Psychopharmacology · doi:10.1007/bf02246184 · Cited by 224 · see citing works
Investigating the Contribution of Common Genetic Variants to the Risk and Pathogenesis of ADHD
Stergiakouli, E., Hamshere, M., Holmans, P., Langley, K., Zaharieva, I., Hawi, Z., Kent, L., Gill, M., Williams, N., Owen, M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040551 · Cited by 220 · see citing works
Regulation of NMDA Receptors by Neuregulin Signaling in Prefrontal Cortex
Gu, Z., Jiang, Q., Fu, A. K. Y., Ip, N. Y., & Yan, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1086-05.2005 · Cited by 213 · see citing works
A circuit for motor cortical modulation of auditory cortical activity
Nelson, A., Schneider, D. M., Takatoh, J., Sakurai, K., Wang, F., & Mooney, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2275-13.2013 · Cited by 213 · see citing works
Self-citationGenetic animal models: focus on schizophrenia
Gainetdinov, R. R., Mohn, A. R., & Caron, M. G. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01886-5 · Cited by 201 · see citing works
Genotype to phenotype relationships in autism spectrum disorders
Chang, J., Gilman, S. R., Chiang, A. H., Sanders, S. J., & Vitkup, D. (2015) · Nature Neuroscience · doi:10.1038/nn.3907 · Cited by 197 · see citing works
Electrical compartmentalization in dendritic spines
Yuste, R. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150455 · Cited by 180 · see citing works
Kim, I. H., Racz, B., Wang, H., Burianek, L., Weinberg, R., Yasuda, R., Wetsel, W. C., & Soderling, S. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0035-13.2013 · Cited by 172 · see citing works
Self-citationGIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
Won, H., Mah, W., Kim, E., Kim, J.-W., Hahm, E.-K., Kim, M.-H., Cho, S., Kim, J., Jang, H., Cho, S.-C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2330 · Cited by 156 · see citing works
Kato, S., Kobayashi, K., Inoue, K.-I., Kuramochi, M., Okada, T., Yaginuma, H., Morimoto, K., Shimada, T., Takada, M., & Kobayashi, K. (2010) · Human Gene Therapy · doi:10.1089/hum.2009.179 · Cited by 150 · see citing works
Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall
Kim, I. H., Wang, H., Soderling, S. H., & Yasuda, R. (2014) · eLife · doi:10.7554/elife.02839 · Cited by 116 · see citing works
Self-citationMcIntosh, A. M., Owens, D. G. C., Moorhead, W. J., Whalley, H. C., Stanfield, A. C., Hall, J., Johnstone, E. C., & Lawrie, S. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.003 · Cited by 115 · see citing works
Carlson, B. R., Lloyd, K. E., Kruszewski, A., Kim, I.-H., Rodriguiz, R. M., Heindel, C., Faytell, M., Dudek, S. M., Wetsel, W. C., & Soderling, S. H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4433-10.2011 · Cited by 114 · see citing works
Self-citationProgress in the Genetics of Polygenic Brain Disorders: Significant New Challenges for Neurobiology
McCarroll, S. A., & Hyman, S. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.046 · Cited by 87 · see citing works
Prefrontal cortical mechanisms underlying delayed alternation in mice
Rossi, M. A., Hayrapetyan, V. Y., Maimon, B. E., Mak, K., Je, H. S., & Yin, H. H. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01060.2011 · Cited by 78 · see citing works
Self-citationAbsent CNKSR 2 causes seizures and intellectual, attention, and language deficits
Vaags, A. K., Bowdin, S. C., Smith, M., Gilbert‐Dussardier, B., Holmefjord, K. S. B., Sinopoli, K. J., Gilles, C., Haaland, T. B., Vincent‐Delorme, C., Lagrue, E., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24274 · Cited by 54 · see citing works
Inositol 1,4,5-Trisphosphate 3-Kinase A Functions As a Scaffold for Synaptic Rac Signaling
Kim, I. H., Park, S. K., Hong, S. T., Jo, Y. S., Kim, E. J., Park, E., Han, S. B., Shin, H., Sun, W., Kim, H. T., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2483-09.2009 · Cited by 45 · see citing works
Self-citationRussell, T. A., Blizinsky, K. D., Cobia, D. J., Cahill, M. E., Xie, Z., Sweet, R. A., Duan, J., Gejman, P. V., Wang, L., Csernansky, J. G., et al. (2014) · Nature Communications · doi:10.1038/ncomms5858 · Cited by 39 · see citing works
Parker, J. G., Beutler, L. R., & Palmiter, R. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2411-11.2011 · Cited by 36 · see citing works
Perspective: Revealing molecular secrets
Hyman, S. E. (2014) · Nature · doi:10.1038/508s20a · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
McCutcheon, R. A., Reis Marques, T., & Howes, O. D. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3360 · Cited by 1,481 · see citing works
Altering the course of schizophrenia: progress and perspectives
Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.28 · Cited by 516 · see citing works
Developmental timing and critical windows for the treatment of psychiatric disorders
Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works
Identification of an elaborate complex mediating postsynaptic inhibition
Uezu, A., Kanak, D. J., Bradshaw, T. W. A., Soderblom, E. J., Catavero, C. M., Burette, A. C., Weinberg, R. J., & Soderling, S. H. (2016) · Science · doi:10.1126/science.aag0821 · Cited by 354 · see citing works
Self-citationInflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization
Howes, O. D., & McCutcheon, R. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.278 · Cited by 288 · see citing works
Howes, O., & Shatalina, E. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.017 · Cited by 233 · see citing works
The synaptic hypothesis of schizophrenia version III: a master mechanism
Howes, O. D., & Onwordi, E. C. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02043-w · Cited by 236 · see citing works
Synaptic nanomodules underlie the organization and plasticity of spine synapses
Hruska, M., Henderson, N., Le Marchand, S. J., Jafri, H., & Dalva, M. B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0138-9 · Cited by 233 · see citing works
Smucny, J., Dienel, S. J., Lewis, D. A., & Carter, C. S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01089-0 · Cited by 231 · see citing works
How Schizophrenia Develops: Cognitive and Brain Mechanisms Underlying Onset of Psychosis
Cannon, T. D. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.09.009 · Cited by 228 · see citing works
Borovac, J., Bosch, M., & Okamoto, K. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.07.001 · Cited by 180 · see citing works
Actin Out: Regulation of the Synaptic Cytoskeleton
Spence, E. F., & Soderling, S. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.655118 · Cited by 171 · see citing works
Self-citationKim, H., Lim, C., & Kaang, B. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0087-y · Cited by 146 · see citing works
Forsyth, J. K., & Lewis, D. A. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.06.006 · Cited by 143 · see citing works
Hultman, R. C., Mague, S. D., Li, Q., Katz, B. M., Michel, N., Lin, L., Wang, J., David, L. K., Blount, C., Chandy, R., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.038 · Cited by 137 · see citing works
Qualls‐Creekmore, E., Yu, S., Francois, M., Hoang, J. G., Huesing, C., Bruce‐Keller, A. J., Burk, D. H., Berthoud, H., Morrison, C. D., & Münzberg, H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0155-17.2017 · Cited by 121 · see citing works
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2360-16.2016 · Cited by 120 · see citing works
Self-citationVentral Tegmental Dopamine Neurons Control the Impulse Vector during Motivated Behavior
Hughes, R. N., Bakhurin, K. I., Petter, E. A., Watson, G. D. R., Kim, N., Friedman, A. D., & Yin, H. H. (2020) · Current Biology · doi:10.1016/j.cub.2020.05.003 · Cited by 116 · see citing works
Self-citationDendritic spine actin dynamics in neuronal maturation and synaptic plasticity
Hlushchenko, I., Koskinen, M., & Hotulainen, P. (2016) · Cytoskeleton · doi:10.1002/cm.21280 · Cited by 109 · see citing works
Parellada, E., & Gassó, P. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01385-9 · Cited by 106 · see citing works
Magno, L. A. V., Tenza‐Ferrer, H., Collodetti, M., Aguiar, M. F. G., Rodrigues, A. P. C., da Silva, R. S., Silva, J. D. P., Nicolau, N. F., Rosa, D. V., Birbrair, A., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2277-18.2019 · Cited by 102 · see citing works
IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders
Kang, J., Park, H., & Kim, E. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.06.019 · Cited by 98 · see citing works
Yin, H. H. (2016) · The Neuroscientist · doi:10.1177/1073858416654115 · Cited by 95 · see citing works
Self-citationBitzenhofer, S. H., Ahlbeck, J., Wolff, A., Wiegert, J. S., Gee, C. E., Oertner, T. G., & Hanganu‐Opatz, I. L. (2017) · Nature Communications · doi:10.1038/ncomms14563 · Cited by 92 · see citing works
Neural circuit dysfunction in mouse models of neurodevelopmental disorders
del Pino, I., Rico, B., & Marín, Ó. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.013 · Cited by 94 · see citing works
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 94 · see citing works
A GABAergic nigrotectal pathway for coordination of drinking behavior
Rossi, M. A., Li, H. E., Lu, D., Kim, I. H., Bartholomew, R. A., Gaidis, E., Barter, J. W., Kim, N., Cai, M., Soderling, S. H., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4285 · Cited by 85 · see citing works
Self-citationNew insights on synaptic dysfunction in neuropsychiatric disorders
Caldeira, G. L., Peça, J., & Carvalho, A. L. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.004 · Cited by 76 · see citing works
Spence, E. F., Kanak, D. J., Carlson, B. R., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0876-16.2016 · Cited by 77 · see citing works
Self-citationMoretti, J., Poh, E. Z., & Rodger, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00137 · Cited by 66 · see citing works
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity
Dube, S., Rácz, B., Brown, W. E., Gao, Y., Soderblom, E. J., Yasuda, R., & Soderling, S. H. (2021) · eLife · doi:10.7554/elife.63756 · Cited by 56 · see citing works
Self-citationLee, T., Kim, S. H., Katz, B., & Mather, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00002 · Cited by 57 · see citing works
van der Kammen, R., Song, J., de Rink, I., Janssen, H., Madonna, S., Scarponi, C., Albanesi, C., Brugman, W., & Innocenti, M. (2017) · Development · doi:10.1242/dev.156323 · Cited by 56 · see citing works
Quiroz, C., Orrù, M., Rea, W. P., Ciudad‐Roberts, A., Yepes, G., Britt, J. P., & Ferré, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2850-15.2016 · Cited by 54 · see citing works
ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier
Schell, C., Sabass, B., Helmstädter, M., Geist, F., Abed, A., Yasuda‒Yamahara, M., Sigle, A., Maier, J. I., Grahammer, F., Siegerist, F., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.11.011 · Cited by 54 · see citing works
Hopkins, J. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00922 · Cited by 53 · see citing works
Efimova, N., Korobova, F., Stankewich, M. C., Moberly, A. H., Stolz, D. B., Wang, J., Kashina, A., Ma, M., & Svitkina, T. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3520-16.2017 · Cited by 50 · see citing works
Ranganath, A., & Jacob, S. N. (2015) · The Neuroscientist · doi:10.1177/1073858415602850 · Cited by 50 · see citing works
Skariah, G., Seimetz, J. W., Norsworthy, M. D., Lannom, M. C., Kenny, P., Elrakhawy, M. M., Forsthoefel, C., Drnevich, J. M., Kalsotra, A., & Ceman, S. (2017) · BMC Biology · doi:10.1186/s12915-017-0387-1 · Cited by 49 · see citing works
Neural circuit pathology driven by Shank3 mutation disrupts social behaviors
Kim, S., Kim, Y.-E., Song, I., Ujihara, Y., Kim, N., Jiang, Y., Yin, H. H., Lee, T., & Kim, I. H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110906 · Cited by 49 · see citing works
Self-citationAuditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia
Hirano, Y., Oribe, N., Onitsuka, T., Kanba, S., Nestor, P. G., Hosokawa, T., Levin, M. E., Shenton, M. E., McCarley, R. W., & Spencer, K. (2020) · Clinical EEG and Neuroscience · doi:10.1177/1550059420914201 · Cited by 48 · see citing works
Simpson, E. H., & Kellendonk, C. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.004 · Cited by 44 · see citing works
Prenatal inflammation and risk for schizophrenia: A role for immune proteins in neurodevelopment
Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 45 · see citing works
Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease
Lauterborn, J. C., Cox, C. D., Chan, S. W., Vanderklish, P. W., Lynch, G., & Gall, C. M. (2020) · Brain Pathology · doi:10.1111/bpa.12779 · Cited by 43 · see citing works
Mechanisms regulating dendritic arbor patterning
Ledda, F., & Paratcha, G. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2588-8 · Cited by 44 · see citing works
Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity
Vinogradov, S., Chafee, M. V., Lee, E. G., & Morishita, H. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01451-w · Cited by 44 · see citing works
Datta, D., Arion, D., Roman, K. M., Volk, D. W., & Lewis, D. A. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16020204 · Cited by 41 · see citing works
Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction
Nakao, K., Jeevakumar, V., Jiang, S. Z., Fujita, Y., Diaz, N. B., Annan, C. A. P., Jaunarajs, K. L. E., Hashimoto, K., Belforte, J., & Nakazawa, K. (2018) · Schizophrenia bulletin · doi:10.1093/schbul/sby003 · Cited by 38 · see citing works
The Arp2/3 complex is essential at multiple stages of neural development
Chou, F., & Wang, P. (2016) · Neurogenesis · doi:10.1080/23262133.2016.1261653 · Cited by 38 · see citing works
Estakhr, J., Abazari, D., Frisby, K., McIntosh, J. M., & Nashmi, R. (2017) · Current Biology · doi:10.1016/j.cub.2017.05.084 · Cited by 40 · see citing works
Weidenauer, A., Bauer, M., Sauerzopf, U., Bartova, L., Nics, L., Pfaff, S., Philippe, C., Berroterán-Infante, N., Pichler, V., Meyer, B., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-019-0681-5 · Cited by 38 · see citing works
Kim, I. H., Kim, N., Kim, S., Toda, K., Catavero, C. M., Courtland, J. L., Yin, H. H., & Soderling, S. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107965 · Cited by 37 · see citing works
Self-citationDatta, D., & Arnsten, A. F. T. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00505 · Cited by 36 · see citing works
Duvarci, S., Simpson, E. H., Schneider, G., Kandel, E. R., Roeper, J., & Sigurdsson, T. (2018) · Nature Communications · doi:10.1038/s41467-018-05214-4 · Cited by 35 · see citing works
Unveiling the pathophysiology of restless legs syndrome through transcriptome analysis
Mogavero, M. P., Salemi, M., Lanza, G., Rinaldi, A., Marchese, G., Ravo, M., Salluzzo, M. G., Antoci, A., DelRosso, L. M., Bruni, O., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109568 · Cited by 35 · see citing works
Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine
Backer, J. D., Monlezun, S., Detraux, B., Gazan, A., Vanopdenbosch, L., Chéron, J., Cannazza, G., Valverde, S., Cantacorps, L., Nassar, M., et al. (2018) · EMBO Reports · doi:10.15252/embr.201745089 · Cited by 33 · see citing works
Alvarez, R. J., Pafundo, D. E., Zold, C. L., & Belforte, J. E. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1897-19.2020 · Cited by 28 · see citing works
Action potential-coupled Rho GTPase signaling drives presynaptic plasticityPreprint
Dube, S., Rácz, B., Brown, W. E., Gao, Y., Soderblom, E. J., Yasuda, R., & Soderling, S. H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.07.330126 · Cited by 31 · see citing works
Self-citationGokhale, A., Hartwig, C. L., Freeman, A. A. H., Das, R., Zlatic, S. A., Vistein, R., Burch, A. M., Carrot, G., Lewis, A. F., Nelms, S., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1321-16.2016 · Cited by 29 · see citing works
Hartwig, C. L., Monis, W. J., Chen, X., Dickman, D. K., Pazour, G. J., & Faúndez, V. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22542 · Cited by 29 · see citing works
Chen, X., Zhu, H., Feng, X., Li, X., Lü, Y., Wang, Z., & Rezgui, Y. (2020) · Communications Biology · doi:10.1038/s42003-020-01335-z · Cited by 28 · see citing works
Low-Level Brain Somatic Mutations Are Implicated in Schizophrenia
Kim, M.-H., Kim, I. B., Lee, J., Cha, D. H., Park, S. M., Kim, J. H., Kim, R., Park, J. S., An, Y., Kim, K., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.014 · Cited by 28 · see citing works
Self-citationSynaptic dysfunction in schizophrenia
Mısır, E., & Akay, G. G. (2023) · Synapse · doi:10.1002/syn.22276 · Cited by 29 · see citing works
Bhambhvani, H. P., Mueller, T., Simmons, M. S., & Meador‐Woodruff, J. H. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0045-y · Cited by 28 · see citing works
Exploring causal mechanisms of psychosis risk
Oliver, D., Chesney, E., Cullen, A. E., Davies, C., Englund, A., Gifford, G., Kerins, S., Lalousis, P. A., Logeswaran, Y., Merritt, K., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105699 · Cited by 28 · see citing works
D’Ambrosio, E., Jauhar, S., Kim, S., Veronese, M., Rogdaki, M., Pepper, F., Bonoldi, I., Kotoula, V., Kempton, M. J., Turkheimer, F., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0570-6 · Cited by 26 · see citing works
Chafee, M. V., & Averbeck, B. B. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.023 · Cited by 26 · see citing works
Klanker, M., Feenstra, M., Willuhn, I., & Denys, D. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.012 · Cited by 25 · see citing works
Longo, F., Aryal, S., Anastasiades, P. G., Maltese, M., Baimel, C., Albanese, F., Tabor, J., Zhu, J. D., Oliveira, M. M., Gastaldo, D., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112901 · Cited by 25 · see citing works
Moya, N. A., Yun, S., Fleps, S. W., Martin, M. M., Nadel, J. A., Beutler, L. R., Zweifel, L. S., & Parker, J. G. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01492-1 · Cited by 24 · see citing works
Chen, X., Li, Y., Guo, M., Xu, B., Ma, Y., Zhu, H., & Feng, X. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306512120 · Cited by 25 · see citing works
The Basal Ganglia and Hierarchical Control in Voluntary Behavior
Yin, H. H. (2016) · Innovations in cognitive neuroscience · doi:10.1007/978-3-319-42743-0_20 · Cited by 24 · see citing works
Self-citationYao, W., Zhou, P., Yan, Q., Wu, X., Xia, Y., Li, W., Li, X., & Zhu, F. (2023) · Viruses · doi:10.3390/v15010168 · Cited by 23 · see citing works
Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain
Hui, M., & Beier, K. T. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.971349 · Cited by 23 · see citing works
Sungur, A. Ö., Stemmler, L., Wöhr, M., & Rust, M. B. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00025 · Cited by 21 · see citing works
Xu, L., Hu, Y., Huang, L., Liu, Y., Wang, B., Xie, L., & Hu, Z. (2019) · Anaesthesia · doi:10.1111/anae.14496 · Cited by 20 · see citing works
Li, R., Wang, X., Lin, F., Song, T., Zhu, X., & Lei, H. C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116588 · Cited by 19 · see citing works
Altered Gray Matter Volumes in Post-Stroke Depressive Patients after Subcortical Stroke
Hong, W., Zhao, Z., Wang, D., Li, M., Tang, C., Li, Z., Xu, R. H., & Chan, C. C. H. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102224 · Cited by 19 · see citing works
Increased Risk of Developing Depression in Disability after Stroke: A Korean Nationwide Study
Choi, H. L., Yang, K., Han, K., Kim, B., Chang, W. H., Kwon, S., Jung, W., Yoo, J. E., Jeon, H. J., & Shin, D. W. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20010842 · Cited by 19 · see citing works
Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice
Graham, K. C., Zhang, J., Qiao, H., Wu, Y., & Zhou, Y. (2019) · Schizophrenia · doi:10.1038/s41537-018-0069-1 · Cited by 19 · see citing works
Sun, W., Yang, J., Hong, Y., Yuan, H., Wang, J., Zhang, Y., Lu, X., Jin, C., Wu, S., & Cai, Y. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00748-7 · Cited by 19 · see citing works
Hyperactive ACC-MDT Pathway Suppresses Prepulse Inhibition in Mice
Kim, Y., Noh, Y. W., Kim, K., & Kim, E. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa090 · Cited by 17 · see citing works
Kim, Y.-E., Kim, M., Kim, S., Lee, R. H., Ujihara, Y., Marquez-Wilkins, E. M., Jiang, Y., Yang, E., Kim, H., Lee, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56720-1 · Cited by 16 · see citing works
Self-citationAntipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application
Tarahovsky, Y. S., Fadeeva, I. S., Komelina, N. P., Khrenov, M. O., & Zakharova, N. M. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4496-2 · Cited by 15 · see citing works
Bakhurin, K. I., Hughes, R. N., Jiang, Q., Hossain, M. A., Gutkin, B. S., Fallon, I. P., & Yin, H. H. (2025) · Nature Communications · doi:10.1038/s41467-025-64132-4 · Cited by 29 · see citing works
Self-citationForsyth, J. K., & Bearden, C. E. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230736 · Cited by 12 · see citing works
The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study
Rogeau, A., Nordio, G., Veronese, M., Brown, K., Nour, M. M., Osugo, M., Jauhar, S., Howes, O. D., & McCutcheon, R. A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01596-6 · Cited by 11 · see citing works
Bonilla-Quintana, M., & Rangamani, P. (2024) · eNeuro · doi:10.1523/eneuro.0497-23.2024 · Cited by 10 · see citing works
The importance of data structure in statistical analysis of dendritic spine morphology
Paternoster, V., Rajkumar, A. P., Nyengaard, J. R., Børglum, A. D., Grove, J., & Christensen, J. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.12.022 · Cited by 10 · see citing works
Molecular mapping of a core transcriptional signature of microglia-specific genes in schizophrenia
Fiorito, A. M., Fakra, É., Sescousse, G., Ibrahim, E. C., & Rey, R. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02677-y · Cited by 9 · see citing works
Decreased expression of cortactin in the schizophrenia brain
Bhambhvani, H. P., Simmons, M. S., Haroutunian, V. H., & Meador‐Woodruff, J. H. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000514 · Cited by 9 · see citing works
Roméo, B., Lestra, V., Martelli, C., Amirouche, A., Benyamina, A., & Hamdani, N. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.24 · Cited by 9 · see citing works
Evaluation of advances in cortical development using model systems
Nano, P. R., & Bhaduri, A. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22879 · Cited by 8 · see citing works
Kim, S., Kim, Y.-E., & Kim, I. H. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101722 · Cited by 6 · see citing works
Self-citationContemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders
Seo, D.-O., Motard, L. E., & Bruchas, M. R. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.03.015 · Cited by 6 · see citing works
Kim, Y.-E., Kim, S., & Kim, I. H. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101807 · Cited by 5 · see citing works
Self-citationEpigenética e Psicologia: Uma Possibilidade de Encontro entre o Social e o Biológico
Faria, A. J. P., Neris, A. R. M. D. T., & de Oliveira, I. P. (2018) · Revista Internacional em Língua Portuguesa · doi:10.31492/2184-2043.rilp2018.34/pp.15-36 · Cited by 5 · see citing works
Known and Unexplored Post-Translational Modification Pathways in Schizophrenia
Smith, B. J., & Carregari, V. C. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-97182-3_6 · Cited by 3 · see citing works
Longo, F., Aryal, S., Anastasiades, P. G., Maltese, M., Baimel, C., Albanese, F., Tabor, J., Zhu, J. D., Oliveira, M. M., Gastaldo, D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.08.519509 · Cited by 3 · see citing works
Lao, H.-C., Huang, C., Wang, S.-H., Su, Y.-L., Chang, C.-H., Liao, C.-Y., Wu, J.-C., Lin, Y.-C., & Tsai, J. (2026) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10273-8 · Cited by 3 · see citing works
- Authors
- Kim, I. H., Rossi, M. A., Aryal, D. K., Racz, B., Kim, N., Uezu, A., Wang, F., Wetsel, W. C., Weinberg, R. J., Yin, H., & Soderling, S. H.
- Affiliations
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Kim, Il Hwan
- Soderling, Scott H
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2015-05-04
- Volume
- 18
- Issue
- 6
- Pages
- 883-891
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4459733
- OpenAlex
- W1808025664
- Cited by
- 127
- References
- 54
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 10 · 2018: 16 · 2017: 15 · 2016: 21 · 2015: 9
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Science Foundation
- North Carolina Biotechnology Center
- Hungarian Scientific Research Fund (K83830)
- Magyar Tudományos Akadémia
- Szent István Egyetem
- National Institutes of Health (AA021074, NS059957)
- National Institute on Alcohol Abuse and Alcoholism (AA021074, R01AA021074)
- National Institute of Mental Health (U19MH082441, MH103374, MH082411, R01MH103374)
- National Institute of Neurological Disorders and Stroke (R01NS039444, NS 077986, R01NS059957, R01NS077986, NS039444, R56NS059957, NS059957)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Arp2/3 complex, actin cytoskeleton, striatal dopamine, hyperdopaminergia, psychomotor agitation, antipsychotic treatment response, cortical excitation, pyramidal neurons, stereotypy, locomotion, mental illness, neurodevelopmental disorders, optogenetic stimulation
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 2, Animals, Dopamine, Female, Locomotion, Male, Mesencephalon, Mutation, Nerve Net, Psychomotor Agitation, Stereotyped Behavior, Antipsychotic Agents, Neostriatum, Prefrontal Cortex, Pyramidal Cells, Mice, Knockout, Patch-Clamp Techniques, Angiopoietins, Dendritic Spines, Actin-Related Protein 3, Mice, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
