The DOI matches its Crossref record.
Haemolytic and nonhaemolytic neonatal jaundice have different risk factor profiles
Abstract
Aim This study examined maternal and pregnancy risk factors for haemolytic and nonhaemolytic neonatal jaundice in a large population-based cohort study. Methods We conducted a cohort study of 1 019 220 singleton live births from the Swedish medical birth register from 1987 to 2002, using information on neonatal jaundice and maternal and pregnancy characteristics. Diagnoses of gestational hypertensive disorders were obtained by linkage to the national inpatient register. Multivariate logistic regression analysis provided odds ratios for the risk factors of both forms of jaundice. Results A total of 6057 (0.6%) births were affected by haemolytic jaundice and 36 869 (3.6%) by nonhaemolytic jaundice. The strongest risk factors for haemolytic jaundice were maternal alloimmunisation, blood group O and neonatal jaundice in older siblings. For nonhaemolytic jaundice, the strongest risk factors were preterm birth, neonatal jaundice in older siblings, maternal origin from East or South-East Asia and maternal obesity. We estimated that 13% of haemolytic jaundice was attributable to alloimmunisation and 39% of nonhaemolytic jaundice was attributable to preterm birth. Conclusion Haemolytic and nonhaemolytic neonatal jaundice had different risk factor profiles. Interventions to reduce maternal alloimmunisation, preterm birth and maternal obesity may lower the prevalence of neonatal jaundice and the risk of consequent neurological complications.
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Research has shown that the prevalence of newborn hyperbilirubinemia may be decreased by interventions that decrease preterm birth.
“Research has shown that the prevalence of newborn hyperbilirubinemia may be decreased by in terventions that decrease preterm birth (Lee et al., 2016).”
From Midwifery continuity of care, breastfeeding and neonatal hyperbilirubinemia: A retrospective cohort study (2024) · cites this paper as Lee et al., 2016
Preterm birth is the main risk factor for nonhemolytic hyperbilirubinemia.
“The top risk factor for nonhemolytic hyperbilirubinemia is preterm birth (Lee et al., 2016)”
From Midwifery continuity of care, breastfeeding and neonatal hyperbilirubinemia: A retrospective cohort study (2024) · cites this paper as Lee et al., 2016
The variance in prevalence could be attributed to the study by Lee et al. only including singleton newborns, whereas this study involved both singleton and multiple pregnancies.
“The variance in prevalence could be attributed to the fact that the study by Lee et al. only included singleton newborns, whereas this study involved both singleton and multiple pregnancies (Lee et al., 2016).”
From Midwifery continuity of care, breastfeeding and neonatal hyperbilirubinemia: A retrospective cohort study (2024) · cites this paper as Lee et al., 2016
The total rate of significant neonatal hyperbilirubinemia in this cohort is higher than the reported prevalence of nonhemolytic hyperbilirubinemia of 3.6% between 1987 and 2020 in Sweden.
“This is higher than the reported prevalence of nonhemolytic hyper bilirubinemia of 3.6 % between 1987 and 2020 in Sweden (Lee et al., 2016).”
From Midwifery continuity of care, breastfeeding and neonatal hyperbilirubinemia: A retrospective cohort study (2024) · cites this paper as Lee et al., 2016
The analysis of neonatal hyperbilirubinemia was constrained by limited access to certain components of participants' medical history, primarily whether the woman had a history of neonatal hyperbilirubinemia.
“The analysis of neonatal hyper bilirubinemia was constrained by limited access to certain components of participants ' medical history, primarily whether the woman had a history of neonatal hyperbilirubinemia, which is a major risk factor (Lee et al., 2016).”
From Midwifery continuity of care, breastfeeding and neonatal hyperbilirubinemia: A retrospective cohort study (2024) · cites this paper as Lee et al., 2016
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Shahshahani, M. A., Liu, X., Norman, M., Tilden, E. L., & Ahlberg, M. (2024) · Midwifery · doi:10.1016/j.midw.2024.104079 · Cited by 7
Metadata
- Authors
- Lee, B. K., Le Ray, I., Sun, J. Y., Wikman, A., Reilly, M., & Johansson, S.
- Affiliations
- Karolinska Institutet (SE)
- Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
- Karolinska University Hospital (SE)
- Corresponding author
- Johansson, Stefan
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2016-06-06
- Volume
- 105
- Issue
- 12
- Pages
- 1444-1450
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2361418622
- Cited by
- 29
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3 · 2016: 3
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet (60521601, C0320601)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Keywords
- neonatal jaundice, preterm birth, maternal obesity, hypertensive disorders of pregnancy, blood group O, risk factors, attributable fraction, neurological complications
- MeSH terms
- Adult, Female, Hemolysis, Humans, Jaundice, Neonatal, Male, Pregnancy, Risk Factors, Sweden, Cohort Studies, Young Adult
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