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Cited by 48Gastrointestinal motility and disordersProbiotics and Fermented FoodsInfant Health and Development

Lactobacillus reuteri DSM 17938 and a placebo both significantly reduced symptoms in children with functional abdominal pain

Maragkoudaki, M, Chouliaras, G, Orel, R, Horvath, A, Szajewska, H, Papadopoulou, A·2017·Acta Paediatrica
DOI 10.1111/apa.13992
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Abstract

Aim: Lactobacillus reuteri is a Gram‐positive bacterium that naturally inhabits the human intestinal tract. This study assessed how effectively the probiotic L. reuteri DSM 17938 managed childhood functional abdominal pain (FAP). Methods: We recruited 54 children with a mean age 9.1 ± 3.8 years, who were diagnosed with FAP in the outpatient clinics of three university hospitals in Greece, Slovenia and Poland, according to the Rome III criteria, from January 2013 to December 2015. They were randomly assigned to receive either 2 × 10 8 colony‐forming units of L. reuteri (n = 27) or a placebo (n = 27) for four weeks. Results: Both L. reuteri and the placebo significantly reduced the frequency and intensity of abdominal pain episodes at four and eight weeks compared to baseline (all p < 0.001). L. reuteri decreased the use of pain relieving drugs at four weeks and the number of child school and adult work absences at four and eight weeks, unlike the placebo, which achieved nonsignificant results. However, the difference between the groups did not reach significance. No side effects were recorded. Conclusion: Both L. reuteri and the placebo were effective in alleviating pain in children with FAP, but only L. reuteri improved the child's and family's normal activities.

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Crossref · 10.1111/apa.13992

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  • In studies focused specifically on FAP, Romano et al. reported reduced pain severity, and Weizman et al. and Maragkoudaki et al. both reported reduced pain severity and frequency in those treated with the probiotic compared with placebo.

    “In studies focused specifically on FAP, Romano et al.138 reported reduced pain severity and Weizman et al.139 and Maragkoudaki et al.140 both reported reduced pain severity and frequency in those treated with the probiotic compared with placebo.”

    From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [140]

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Authors
Maragkoudaki, M., Chouliaras, G., Orel, R., Horvath, A., Szajewska, H., & Papadopoulou, A.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • University of Ljubljana (SI)
  • Medical University of Warsaw (PL)
Corresponding author
Papadopoulou, A
ORCID
Venue
Acta Paediatrica
Publisher
Wiley
Published
2017-08-22
Volume
106
Issue
11
Pages
1857-1862
ISSN
  • 0365-1436 (ISSN-L)
  • 0803-5253
  • 1651-2227
DOI
10.1111/apa.13992
OpenAlex
W2736234932
Cited by
48
References
28
Citations by year
2026: 6 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 8
FWCI
4.02
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Paediatrica (publishedVersion)
  • PubMed (publishedVersion)
Funders
BioGaia
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords
Lactobacillus reuteri, probiotics, functional abdominal pain, children, Rome III criteria
MeSH terms
Adolescent, Child, Child, Preschool, Double-Blind Method, Female, Humans, Male, Abdominal Pain, Probiotics, Limosilactobacillus reuteri

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