CoChat
Sign Up
Cited by 9Infant Development and Preterm CareNeonatal and fetal brain pathologyNeonatal Respiratory Health Research

Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years

Zaigham, Mehreen, Källén, Karin, Maršál, Karel, Olofsson, Per·2020·Acta Paediatrica
DOI 10.1111/apa.14925
Open this paper in CoChat — free account

Abstract

Abstract Aim It is not clear whether perinatal acidosis can predict poor outcomes in extremely preterm infants and we investigated associations between intrapartum hypoxia and mortality and neurodevelopmental outcomes. Methods We used nationwide data on 705 infants from the Extremely Preterm Infants in Sweden Study, delivered at 22‐26 weeks of gestation during 2004‐2007. Comprehensive neurodevelopmental assessments were performed on survivors at 2.5 (n = 456) and 6.5 (n = 441) years of corrected age. Gestational age‐related changes in umbilical cord arterial pH were compared with reference values for term newborn infants, and base excess was also calculated. Associations between low blood gas values (<10th percentile) and mortality and neurodevelopmental outcome were estimated. Results Cord blood determination was more common in surviving infants (P < .001), with pH determined in 322/705 (46%) and base excess in 311/705 (44%). Extremely preterm infants had higher pH values than term infants (P < .0001), with no change from 22 to 26 weeks of gestation (P = .61, r2 = .001). Multiple logistic regression showed no association between low blood gas values and risk of death or neurodevelopmental impairment at 6.5 years (P ≥ .17). Conclusion Hypoxia with acidosis at birth was not associated with an increased risk of death or impaired neurodevelopmental in extremely preterm born children at 6.5 years.

Integrity signals

Registry

Crossref · 10.1111/apa.14925

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Among 322 children born extremely preterm (at 22-26 weeks' gestation), the authors found no association between acidosis at birth and risk of death or neurodevelopmental impairment at age 6.5 years.

    “Among 322 children born extremely preterm (at 22e26 weeks' gestation), we found no association between acidosis at birth and risk of death or neurodevelopmental impairment at the age”

    From Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility. (2023) · cites this paper as [95]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Zaigham, M., Källén, K., Maršál, K., & Olofsson, P.
Affiliations
Lund University (SE)
Corresponding author
Zaigham, Mehreen
ORCID
Venue
Acta Paediatrica
Publisher
Wiley
Published
2019-08
Volume
109
Issue
1
Pages
85-92
ISSN
  • 0365-1436 (ISSN-L)
  • 0803-5253
  • 1651-2227
DOI
10.1111/apa.14925
OpenAlex
W2953598479
Cited by
9
References
19
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 2
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Paediatrica (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
Lunds Universitet
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
extremely preterm infants, intrapartum hypoxia, umbilical cord blood gas, cord blood pH, base excess, neurodevelopmental outcomes, infant mortality, very preterm birth
MeSH terms
Acidosis, Respiratory, Hypoxia, Blood Gas Analysis, Child, Fetal Blood, Gestational Age, Humans, Infant, Newborn, Sweden, Infant, Extremely Premature, Neurodevelopmental Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review