The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Clinical trials in children
Open accessAbstract
Safety and efficacy data on many medicines used in children are surprisingly scarce. As a result children are sometimes given ineffective medicines or medicines with unknown harmful side effects. Better and more relevant clinical trials in children are needed to increase our knowledge of the effects of medicines and to prevent the delayed or non‐use of beneficial therapies. Clinical trials provide reliable evidence of treatment effects by rigorous controlled testing of interventions on human subjects. Paediatric trials are more challenging to conduct than trials in adults because of the paucity of funding, uniqueness of children and particular ethical concerns. Although current regulations and initiatives are improving the scope, quantity and quality of trials in children, there are still deficiencies that need to be addressed to accelerate radically equitable access to evidence‐based therapies in children.
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Cites
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Cited by
Akdis (2020) · doi:10.1111/pai.13189 · Cited by 320
Wollmer, E., Karkossa, F., Freerks, L., Hetberg, A.-E., Neal, G., Porter, J., Whitaker, M. J., Margetson, D., & Klein, S. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02912-x · Cited by 30
Jong, M. C., Boers, I., van Wietmarschen, H., Busch, M., Naafs, M. C., Kaspers, G. J. L., & Tissing, W. J. E. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-019-05058-8 · Cited by 28
Ye, Q., Sun, S., Deng, J., Chen, X., Zhang, J., Lin, S., Du, H., Gao, J., Zou, X., Lin, X., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-47760-y · Cited by 11
Metadata
- Authors
- Joseph, P. D., Craig, J. C., & Caldwell, P. H. Y.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2015-02-20
- Volume
- 79
- Issue
- 3
- Pages
- 357-369
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W1831893120
- Cited by
- 393
- References
- 80
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Joseph, P. D., Craig, J. C., & Caldwell, P. H. Y. (2015). Clinical trials in children. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.12305
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
