The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)
Abstract
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis extracts which has high affinity on a series of receptors, including Type 1 cannabinoid receptor (CB1), Type 2 cannabinoid receptor (CB2), GPR55, transient receptor potential vanilloid (TRPV) and peroxisome proliferator‐activated receptor gamma (PPARγ). By modulating the activities of these receptors, CBD exhibits multiple therapeutic effects, including neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti‐inflammatory, analgesic and anticancer properties. CBD could also be applied to treat or prevent COVID‐19 and its complications. Here, we provide a narrative review of CBD's applications in human diseases: from mechanism of action to clinical trials.
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Cites
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A classification of chronic pain for ICD-11
Treede, R.-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000160 · Cited by 2,822
Epidemiology of anxiety disorders in the 21st century
Bandelow, B., & Michaelis, S. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/bbandelow · Cited by 2,079 · cited 1×
“Anxiety disorders have the highest lifetime prevalence of any mental illness worldwide, leading to high social and economic burden.(50) Anxiety is an emotional disorder characterized by feelings of tension, worried thoughts and changes such as increased blood pressure and heart rate.”
BackgroundThe molecular logic of endocannabinoid signalling
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Neuronal circuits for fear and anxiety
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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
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Metadata
- Authors
- Peng, J., Fan, M., An, C., Ni, F., Huang, W., & Luo, J.
- Venue
- Basic & Clinical Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 2022-02-06
- Volume
- 130
- Issue
- 4
- Pages
- 439-456
- ISSN
- 1742-7835 (ISSN-L)
- 1742-7843
- OpenAlex
- W4210607766
- Cited by
- 282
- References
- 159
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peng, J., Fan, M., An, C., Ni, F., Huang, W., & Luo, J. (2022). A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD). Basic & Clinical Pharmacology & Toxicology. https://doi.org/10.1111/bcpt.13710
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
