Demography, baseline disease characteristics and treatment history of patients with psoriasis enrolled in a multicentre, prospective, disease‐based registry (PSOLAR)
Open accessAbstract
BACKGROUND: Psoriasis is associated with several comorbidities and behavioural risk factors. OBJECTIVES: To evaluate demographic and disease characteristics in patients enrolled in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METHODS: PSOLAR is a global, prospective, longitudinal, disease-based registry that includes a postmarketing commitment to evaluate safety in patients with psoriasis. Enrolled patients had to be receiving, or be eligible to receive, conventional systemic or biological agents. Demographic/disease characteristics, medical histories, lifestyle risk factors and previous treatments are collected at enrolment. Efficacy and safety data are collected every 6 months for 8 years, and data are extracted annually. Selected parameters are evaluated by age quartile using post hoc analyses. RESULTS: As of 23 August 2012, 11 900 patients were enrolled at 301 sites in North America, Europe and Latin America. Over half of the PSOLAR population (54·7%) is male, with a mean age of 48·6 years and mean body mass index of 30·9 kg m(-2) at enrolment. Mean duration of disease at enrolment was 17·5 years, and mean Physician's Global Assessment score was 2·0. Psoriatic arthritis (35·5%) and cardiovascular diseases (38·2%) were highly prevalent. Diabetes mellitus type II was reported in 11·4% of patients. Depression and anxiety were noted in 14·7% and 11·1% of patients, respectively; 79·0% reported any alcohol use and 56·7% reported smoking or a history of smoking. The occurrence of most comorbidities, including cardiovascular disease and risk factors, increased with age. CONCLUSIONS: In the PSOLAR population, multiple and age-appropriate comorbidities are associated with psoriasis and may affect the selection of psoriasis treatments.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The finding of anxiety in 17% of patients is higher than a global longitudinal study showing anxiety in 11% of psoriasis patients but in accordance with a Canadian study using the HADS.
“Our finding of anxiety in 17% of patients is higher compared with the findings of a global longitudinal study on psoriasis showing anxiety in 11% of patients (Kimball et al., 2014) but in accordance with a recent study of psoriasis patients from Canada using the HADS (McDonough et al., 2014).”
From The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries (2015) · cites this paper as Kimball et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pathogenesis and clinical features of psoriasis
Griffiths, C. E. M., & Barker, J. N. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61128-3 · Cited by 2,159 · see citing works
Leonardi, C. L., Kimball, A. B., Papp, K. A., Yeilding, N. M., Guzzo, C. A., Wang, Y., Li, S., Dooley, L. T., & Gordon, K. B. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60725-4 · Cited by 1,870 · see citing works
Self-citationPsoriatic arthritis: epidemiology, clinical features, course, and outcome
Gladman, D. D., Antoni, C., Mease, P. J., Clegg, D. O., & Nash, P. T. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.032482 · Cited by 1,538 · see citing works
Papp, K. A., Langley, R. G. B., Lebwohl, M., Krueger, G. G., Szapary, P. O., Yeilding, N. M., Guzzo, C. A., Hsu, M.-C., Wang, Y., Li, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60726-6 · Cited by 1,358 · see citing works
Guidelines of care for the management of psoriasis and psoriatic arthritis
Menter, A., Gottlieb, A. B., Feldman, S. R., Voorhees, A. S. V., Leonardi, C. L., Gordon, K. B., Lebwohl, M., Koo, J. Y. M., Elmets, C. A., Korman, N. J., et al. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.02.039 · Cited by 1,220 · see citing works
Self-citationEtanercept as Monotherapy in Patients with Psoriasis
Leonardi, C. L., POWERS, J. L., Matheson, R. T., Goffe, B. S., Zitnik, R. J., Wang, A., & Gottlieb, A. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030409 · Cited by 1,173 · see citing works
Self-citationTyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069 · see citing works
Self-citationReich, K., Nestle, F. O., Papp, K. A., Ortonne, J. P., Evans, R., Guzzo, C. A., Li, S., Dooley, L. T., & Griffiths, C. E. M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67566-6 · Cited by 1,045 · see citing works
Prevalence of cardiovascular risk factors in patients with psoriasis
Neimann, A. L., Shin, D. B., Wang, X., Margolis, D. J., Troxel, A. B., & Gelfand, J. M. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.08.040 · Cited by 1,010 · see citing works
Registries for Evaluating Patient Outcomes: A User’s Guide
(2020) · doi:10.23970/ahrqepcregistries4 · Cited by 968 · see citing works
Adalimumab therapy for moderate to severe psoriasis: A randomized, controlled phase III trial
Menter, A., Tyring, S. K., Gordon, K. B., Kimball, A. B., Leonardi, C. L., Langley, R. G. B., Strober, B. E., Kaul, M., Gu, Y., Okun, M. M., et al. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.09.010 · Cited by 886 · see citing works
Self-citationRubin, A. I., Chen, E. H., & Ratner, D. (2005) · New England Journal of Medicine · doi:10.1056/nejmra044151 · Cited by 772 · see citing works
Davidovici, B. B., Sattar, N. A., Prinz, J. C., Puig, L., Emery, P., Barker, J. N., van de Kerkhof, P., Ståhle, M., Nestle, F. O., Girolomoni, G., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.103 · Cited by 713 · see citing works
The Risk of Depression, Anxiety, and Suicidality in Patients With Psoriasis
Chosidow, O., ROBERT, P. D., DAIHUNG, D., URBÀ, G., CATALIN, M. P., Hywel, W., Kurd, S. K., Troxel, A. B., Crits-Christoph, P. F., & Gelfand, J. M. (2010) · Archives of Dermatology · doi:10.1001/archdermatol.2010.186 · Cited by 646 · see citing works
New IBD genetics: common pathways with other diseases
Lees, C. W., Barrett, J. C., Parkes, M., & Satsangi, J. (2011) · Gut · doi:10.1136/gut.2009.199679 · Cited by 635 · see citing works
Bernstein, C., Wajda, A., & Blanchard, J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.021 · Cited by 599 · see citing works
A Novel Targeted T-Cell Modulator, Efalizumab, for Plaque Psoriasis
Lebwohl, M., Tyring, S. K., Hamilton, T. K., Toth, D. P., Glazer, S. D., Tawfik, N., Walicke, P. A., Dummer, W., Wang, X., Garovoy, M. R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030002 · Cited by 571 · see citing works
Menter, A., Feldman, S. R., Weinstein, G. D., Papp, K. A., Evans, R. J., Guzzo, C. A., Li, S., Dooley, L. T., Arnold, C. M., & Gottlieb, A. B. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.07.017 · Cited by 516 · see citing works
Self-citationArmstrong, A. W., Harskamp, C. T., & Armstrong, E. J. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.26 · Cited by 515 · see citing works
Psoriasis Severity and the Prevalence of Major Medical Comorbidity
Yeung, H., Takeshita, J., Mehta, N. N., Kimmel, S. E., Ogdie, A., Margolis, D. J., Shin, D. B., Attor, R., Troxel, A. B., & Gelfand, J. M. (2013) · JAMA Dermatology · doi:10.1001/jamadermatol.2013.5015 · Cited by 463 · see citing works
Kimball, A. B., Gladman, D. D., Gelfand, J. M., Gordon, K. B., Horn, E. J., Korman, N. J., Korver, G., Krueger, G. G., Strober, B. E., & Lebwohl, M. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.01.006 · Cited by 431 · see citing works
Self-citationArchier, E., Devaux, S., Castela, E., Gallini, A., Aubin, F., Maître, M. L., Aractingi, S., Bachelez, H., Cribier, B. J., Joly, P., et al. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2012.04520.x · Cited by 311 · see citing works
Risk of cancer in psoriasis: a systematic review and meta‐analysis of epidemiological studies
Pouplard, C., Brenaut, E., Horreau, C., et al. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12165 · Cited by 255 · see citing works
Miele, L., Vallone, S., Cefalo, C., La Torre, G., Di Stasi, C., Vecchio, F. M., D’Agostino, M., Gabrieli, M. L., Vero, V., Biolato, M., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.06.008 · Cited by 249 · cited 1× · see citing works
“41,42 The lower prevalence observed in the PSOLAR population may reflect the design of the case report form, which allows for proactive inquiry about only certain hepatic conditions.”
BackgroundRelationship Between Smoking and the Clinical Severity of Psoriasis
Fortes, C., Mastroeni, S., Leffondré, K., Sampogna, F., Melchi, F., Mazzotti, E., Pasquini, P., & ABENI, D. D. (2005) · Archives of Dermatology · doi:10.1001/archderm.141.12.1580 · Cited by 246 · see citing works
Langley, R. G. B., Feldman, S. R., Han, C., Schenkel, B., Szapary, P. O., Hsu, M.-C., Ortonne, J. P., Gordon, K. B., & Kimball, A. B. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.09.014 · Cited by 218 · see citing works
Self-citationMenter, A., Augustin, M., Signorovitch, J., Yu, A. P., Wu, E. Q., Gupta, S. R., Bao, Y., & Mulani, P. M. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.07.022 · Cited by 197 · see citing works
Self-citationPsoriasis associated with ulcerative colitis and Crohn's disease
Cohen, A., Dreiher, J., & Birkenfeld, S. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.03031.x · Cited by 194 · see citing works
Medical comorbidity associated with psoriasis in adults: a population-based study
Yang, Y., Keller, J. J., & Lin, H. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10494.x · Cited by 174 · see citing works
Psoriasis: depression, anxiety, smoking, and drinking habits
Hayes, J. M., & Koo, J. Y. M. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01312.x · Cited by 167 · see citing works
Shipman, A. R., & Millington, G. W. M. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10393.x · Cited by 148 · see citing works
Comorbidities in Psoriasis Patients
Kim, N., Thrash, B., & Menter, A. (2010) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2010.01.002 · Cited by 125 · see citing works
Self-citationThe use of claims data in healthcare research.
Ferver, K., Burton, B., & Jesilow, P. (2009) · The Open Public Health Journal · doi:10.2174/1874944500902010011 · Cited by 103 · see citing works
Psoriasis and chronic obstructive pulmonary disease: a case-control study
Dreiher, J., Weitzman, D., Shapiro, J. S., Davidovici, B. B., & Cohen, A. D. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08749.x · Cited by 102 · see citing works
Madanagobalane, S., & Anandan, S. (2012) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.2012.00905.x · Cited by 95 · see citing works
Systemic methotrexate therapy for psoriasis: past, present and future
Dogra, S., & Mahajan, R. (2013) · Clinical and Experimental Dermatology · doi:10.1111/ced.12062 · Cited by 94 · see citing works
Psoriasis Comorbidities: Results from the National Psoriasis Foundation Surveys 2003 to 2011
Armstrong, A. W., Schupp, C. W., & Bebo, B. F. (2012) · Dermatology · doi:10.1159/000342180 · Cited by 92 · see citing works
Feldman, S. R., Gottlieb, A. B., BALA, M. M., Wu, Y., Eisenberg, D. F., Guzzo, C. A., Li, S., Dooley, L. T., & Menter, A. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08727.x · Cited by 86 · see citing works
Self-citationPapp, K. A., Strober, B. E., Augustin, M., et al. (2012) · PubMed · Cited by 82 · see citing works
Guenther, L., & Gulliver, W. P. F. (2009) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2009.00024 · Cited by 78 · see citing works
Self-citationPsoriasis and metabolic syndrome
Takahashi, H., & Iizuka, H. (2012) · Journal of dermatology (Print) · doi:10.1111/j.1346-8138.2011.01408.x · Cited by 75 · see citing works
Christophers, E. (2006) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.01773.x · Cited by 61 · see citing works
Wakkee, M., & Nijsten, T. E. C. (2009) · Dermatologic Clinics · doi:10.1016/j.det.2008.11.013 · Cited by 60 · see citing works
Psoriasis Therapy in Real Life: The Need for Registries
Schmitt‐Egenolf, M. (2006) · Dermatology · doi:10.1159/000096196 · Cited by 57 · see citing works
Epidemiology of psoriatic arthritis
Catanoso, M., Pipitone, N., & Salvarani, C. (2012) · Reumatismo · doi:10.4081/reumatismo.2012.66 · Cited by 51 · see citing works
Is there truly a risk of lymphoma from biologic therapies?
Dommasch, E. D., & Gelfand, J. M. (2009) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2009.01258.x · Cited by 49 · see citing works
The unmet treatment need for moderate to severe psoriasis: results of a survey and chart review
Christophers, E., Griffiths, C., Gaitanis, G., et al. (2006) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.01667.x · Cited by 43 · see citing works
Harris, E. A. (1994) · PubMed · Cited by 39 · see citing works
Methodologic Issues in Observational Studies
Hartz, A. J., & Marsh, J. L. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000079325.41006.95 · Cited by 37 · see citing works
Kimball, A. B., Pariser, D. M., Yamauchi, P. S., Menter, A., Teller, C. F., Shi, Y., Yong, M., Creamer, K., Hooper, M. M., Aras, G. A., et al. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.10.055 · Cited by 33 · see citing works
Self-citationGulliver, W. P. F., MacDonald, D., Gladney, N., Alaghehbandan, R., Rahman, P., & Baker, K. A. (2011) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2010.10013 · Cited by 29 · see citing works
Self-citationPsoriasis in Swedish conscripts: time trend and association with T-helper 2-mediated disorders
Landgren, E., Bråbäck, L., Hedlin, G., et al. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.07004.x · Cited by 20 · see citing works
Kim, G. E., Seidler, E. M., & Kimball, A. B. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12089 · Cited by 19 · see citing works
Self-citationPsoriasis: background and clinical features
Griffiths, C. E. M., & Barker, J. E. (2007) · Research Explorer (The University of Manchester) · Cited by 14 · see citing works
The AWARE Study: Methodology and Baseline Characteristics
Bissonnette, R., Searles, G. E., Landells, I. D. R., et al. (2009) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2009.00029 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dalgard, F. J., Gieler, U., Tomas-Aragones, L., Lien, L., Poot, F., Jemec, G. B. E., Misery, L., Szabo, C., Linder, D., Sampogna, F., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.530 · Cited by 968 · see citing works
Unmet medical needs in chronic, non-communicable inflammatory skin diseases
Ujiie, H., Rosmarin, D., Schön, M. P., Ständer, S., Boch, K., Metz, M., Maurer, M., Thaci, D., Schmidt, E., Cole, C., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.875492 · Cited by 158 · see citing works
- Authors
- Kimball, A. B., Leonardi, C., Stahle, M., Gulliver, W., Chevrier, M., Fakharzadeh, S., Goyal, K., Calabro, S., Langholff, W., Menter, A., & the PSOLAR Steering Committee
- Affiliations
- Harvard University (US)
- Saint Louis University (US)
- Karolinska Institutet Stockholm Sweden
- Memorial University of Newfoundland (CA)
- Janssen Scientific Affairs (United States) (US)
- Janssen Research & Development LLC Horsham PA U.S.A
- Baylor University Medical Center (US)
- Corresponding author
- Kimball, A.B.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-07
- Volume
- 171
- Issue
- 1
- Pages
- 137-147
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- PMC
- PMC4232924
- OpenAlex
- W2132923004
- Cited by
- 117
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 15 · 2019: 17 · 2018: 11 · 2017: 14 · 2016: 11 · 2015: 9 · 2014: 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- British Journal of Dermatology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Janssen Biotech
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- psoriasis, comorbidities, psoriatic arthritis, cardiovascular disease, type 2 diabetes, depression, anxiety, smoking, alcohol consumption, body mass index, disease duration, treatment history, biologic therapy, systemic therapy, patient demographics, risk factors
- MeSH terms
- Adolescent, Adult, Aged, Biological Products, Dermatologic Agents, Europe, Female, Humans, Latin America, Male, Middle Aged, North America, Obesity, Pedigree, Photochemotherapy, Prospective Studies, Psoriasis, Registries, Risk-Taking, Comorbidity, Body Mass Index, Photosensitizing Agents, Age Distribution, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
