Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma
Abstract
Optical coherence tomography (OCT) is a noninvasive imaging tool used in vivo in real time for diagnosis, treatment delineation and monitoring of basal cell carcinoma (BCC). Features of BCC on OCT have been widely described and reviewed. However, the diagnostic accuracy of OCT in these various applications is unclear. We systematically reviewed the literature to assess the accuracy of OCT in diagnosis and management of BCC using the Embase and Medline databases. In total 179 unique references were identified in the initial search, of which 22 studies with 556 histologically proven BCCs were eligible. Assessment of the quality of eligible studies was undertaken using the STROBE criteria. Data extraction and quality assessment were performed independently by the two authors. This systematic review provides an overview of the clinical applications of OCT in the diagnosis and management of BCC. OCT has been suggested to be useful in the diagnosis, treatment planning and treatment monitoring of BCC. As the technology improves and its utility increases, further studies with good methodological quality will be needed to implement OCT into daily practice.
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Sufficient reporting quality was assigned to studies meeting 12 specified STROBE items, corresponding to more than 50% of all 22 items.
“Fulfilment of these 12 STROBE items corresponds to more than 50% of all 22 STROBE items, a cutoff which has been used in several previous studies [9–11].”
From Wearable sensors for clinical applications in epilepsy, Parkinson’s disease, and stroke: A mixed-methods systematic review (2018) · cites this paper as [10]
Cites
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · Bulletin of the World Health Organization · doi:10.2471/blt.07.045120 · Cited by 1,632 · see citing works
Non‐melanoma skin cancer in Australia: the 2002 national survey and trends since 1985
Staples, M., Elwood, M., Burton, R. C., et al. (2006) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2006.tb00086.x · Cited by 686 · see citing works
Advances in Optical Coherence Tomography Imaging for Dermatology
Pierce, M. C., Strasswimmer, J., Park, B. H., Cense, B., & de Boer, J. F. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23404.x · Cited by 258 · see citing works
Optical coherence tomography in dermatology: technical and clinical aspects
Gambichler, T., Jaedicke, V., & Terras, S. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1152-x · Cited by 240 · see citing works
Non‐melanoma skin cancer in Australia
Fransen, M., Karahalios, A., Sharma, N., English, D. R., Giles, G. G., & Sinclair, R. D. (2012) · The Medical Journal of Australia · doi:10.5694/mja12.10654 · Cited by 221 · see citing works
Mogensen, M., & Jemec, G. B. E. (2007) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2007.33251.x · Cited by 210 · see citing works
Mogensen, M., Joergensen, T. M., Nürnberg, B. M., Morsy, H. A., Thomsen, J. B., Thrane, L., & Jemec, G. B. E. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2009.01164.x · Cited by 205 · see citing works
OCT imaging of skin cancer and other dermatological diseases
Mogensen, M., Thrane, L., Jørgensen, T. M., Andersen, P. E., & Jemec, G. B. E. (2009) · Journal of Biophotonics · doi:10.1002/jbio.200910020 · Cited by 201 · see citing works
Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma
Strasswimmer, J., Pierce, M. C., Park, B. H., Neel, V., & de Boer, J. F. (2004) · Journal of Biomedical Optics · doi:10.1117/1.1644118 · Cited by 167 · see citing works
Ulrich, M., von Braunmühl, T., Kurzen, H., Dirschka, T., Kellner, C. H., Sattler, E., Berking, C., Welzel, J., & Reinhold, U. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13853 · Cited by 159 · see citing works
Using optical coherence tomography to evaluate skin sun damage and precancer
Korde, V. R., Bonnema, G. T., Xu, W., Krishnamurthy, C., Ranger‐Moore, J., Saboda, K., Slayton, L. D., Salasche, S. J., Warneke, J. A., Alberts, D. S., et al. (2007) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20573 · Cited by 145 · see citing works
Mogensen, M., Nürnberg, B. M., Forman, J. L., Thomsen, J. B., Thrane, L., & Jemec, G. B. E. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.09003.x · Cited by 144 · see citing works
Optical techniques for the noninvasive diagnosis of skin cancer
Călin, M. A., Parasca, S. V., Savastru, R., Calin, M. R., & Donţu, S. (2013) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-013-1423-3 · Cited by 135 · see citing works
Ex vivo fluorescence confocal microscopy for fast evaluation of tumour margins during Mohs surgery
Bennássar, A., Vilata, A., Puig, S., et al. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12671 · Cited by 122 · see citing works
Alawi, S. A., Kuck, M., Wahrlich, C., Batz, S., McKenzie, G., Fluhr, J. W., Lademann, J. M., & Ulrich, M. (2013) · Experimental Dermatology · doi:10.1111/exd.12196 · Cited by 120 · see citing works
Noninvasive diagnostic tools for nonmelanoma skin cancer
Ulrich, M., Stockfleth, E., Roewert-Huber, J., & Astner, S. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08275.x · Cited by 118 · see citing works
Jørgensen, T. M., Tycho, A., Mogensen, M., Bjerring, P., & Jemec, G. B. E. (2008) · Skin Research and Technology · doi:10.1111/j.1600-0846.2008.00304.x · Cited by 113 · see citing works
In vivo optical coherence tomography for the diagnosis of oral malignancy
Wilder-Smith, P. B. B., Jung, W., Brenner, M., et al. (2004) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20098 · Cited by 106 · see citing works
Schmid-Wendtner, M., Hinz, T., Ehler, L., et al. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1231 · Cited by 82 · see citing works
Histological correlates of optical coherence tomography in non‐melanoma skin cancer
Coleman, A. J., Richardson, T. J., Orchard, G. E., Uddin, A., Choi, M. J., & Lacy, K. E. (2012) · Skin Research and Technology · doi:10.1111/j.1600-0846.2012.00626.x · Cited by 81 · see citing works
Use of High-Frequency, High-Resolution Ultrasound Before Mohs Surgery
Marmur, E. S., BERKOWITZ, E. Z., Fuchs, B. S., et al. (2010) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2010.01558.x · Cited by 80 · see citing works
Desai, T., DESAI, A. D., HOROWITZ, D. C., et al. (2007) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2007.33257.x · Cited by 78 · see citing works
Sonography of Facial Cutaneous Basal Cell Carcinoma
Wortsman, X. (2013) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2013.32.4.567 · Cited by 77 · see citing works
Wang, K. X., Meekings, A., Fluhr, J. W., et al. (2013) · Dermatologic Surgery · doi:10.1111/dsu.12093 · Cited by 77 · see citing works
Themstrup, L., Banzhaf, C. A., Mogensen, M., et al. (2013) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2013.11.003 · Cited by 71 · see citing works
Olmedo, J. M., Warschaw, K. E., Schmitt, J. M., et al. (2007) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2007.33088.x · Cited by 71 · see citing works
Longo, C., Rajadhyaksha, M. M., Ragazzi, M., et al. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13070 · Cited by 71 · see citing works
Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy
Banzhaf, C. A., Themstrup, L., Ring, H. C., Mogensen, M., & Jemec, G. B. E. (2013) · Skin Research and Technology · doi:10.1111/srt.12102 · Cited by 62 · see citing works
Optical Coherence Tomography: Clinical Applications in Dermatology
Steiner, R. W., Kunzi‐Rapp, K., & Scharffetter‐Kochanek, K. (2003) · Medical Laser Application · doi:10.1078/1615-1615-00107 · Cited by 61 · see citing works
Hoogedoorn, L., Peppelman, M., van de Kerkhof, P. C. M., van Erp, P. E. J., & Gerritsen, M. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13499 · Cited by 57 · see citing works
Pomerantz, R. G., Zell, D. S., McKenzie, G., et al. (2011) · Case Reports in Dermatology · doi:10.1159/000333000 · Cited by 51 · see citing works
Turning the tide? Changes in treatment rates for keratinocyte cancers in Australia 2000 through 2011
Olsen, C. M., Williams, P. F., & Whiteman, D. C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.02.011 · Cited by 50 · see citing works
Maier, T., Kulichová, D., Ruzicka, T., & Berking, C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.04.007 · Cited by 46 · see citing works
Forsea, A., Carstea, E. M., Ghervase, L., Giurcăneanu, C., & Pavelescu, G. (2010) · PubMed Central · Cited by 42 · see citing works
Cunha, D., Richardson, T., Sheth, N., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10461.x · Cited by 42 · see citing works
Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study
Hamdoon, Z., Jerjes, W., Upile, T., et al. (2010) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.08.004 · Cited by 39 · see citing works
Durkin, J. R., Fine, J. L., Sam, H., et al. (2014) · Dermatologic Surgery · doi:10.1111/dsu.12419 · Cited by 37 · see citing works
Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer
Drakaki, E., Vergou, T., Dessinioti, C., Stratigos, A., Sălăvăstru, C., & Antoniou, C. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.6.061221 · Cited by 35 · see citing works
Maier, T., Kulichová, D., Ruzicka, T., et al. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12063 · Cited by 34 · see citing works
Chen, W., Hu, P., Ghazaryan, A. A., Chen, S., Tsai, T., & Dong, C. (2012) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2012.06.003 · Cited by 33 · see citing works
Mogensen, M., Nürnberg, B. M., Thrane, L., Jørgensen, T. M., Andersen, P. E., & Jemec, G. B. E. (2011) · Journal of Biophotonics · doi:10.1002/jbio.201100006 · Cited by 32 · see citing works
An introduction to primary skin imaging
Dasgeb, B., Kainerstorfer, J. M., Mehregan, D. R., Vreede, A. V., & Gandjbakhche, A. (2013) · International Journal of Dermatology · doi:10.1111/ijd.12048 · Cited by 23 · see citing works
Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report
Chan, C. S., & Rohrer, T. E. (2012) · Case Reports in Dermatology · doi:10.1159/000346237 · Cited by 18 · see citing works
Pelosini, L., Smith, H. B., Schofield, J. B., et al. (2013) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2012-303043 · Cited by 18 · see citing works
Use of high-definition optical coherent tomography (HD-OCT) for imaging of melanoma
Picard, A., Tsilika, K., Long-Mira, É., Hofman, P. M., Passeron, T., Lacour, J. ‐., & Bahadoran, P. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12433 · Cited by 17 · see citing works
Coleman, A. J., Penney, G., Richardson, T. J., Guyot, A., Choi, M. J., Sheth, N., Craythorne, E. E., Robson, A., & Mallipeddi, R. (2014) · Computer Aided Surgery · doi:10.3109/10929088.2014.885085 · Cited by 16 · see citing works
In vivodetermination of epidermal thickness using high-definition optical coherence tomography
Gambichler, T., Valavanis, K. D., Plura, I., et al. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12668 · Cited by 11 · see citing works
Grattan, C. E. H. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13112 · Cited by 11 · see citing works
Optical coherence tomography in clinical examinations of nonpigmented skin malignancies
Jensen, L. K., Thrane, L., Andersen, P. E., et al. (2003) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.500665 · Cited by 11 · see citing works
Happe, M., Freitag, M., Stücker, M., et al. (1997) · PubMed · Cited by 7 · see citing works
Mirror, mirror on the wall…how photodamaged am I?
Harland, C. C. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10548.x · Cited by 1 · see citing works
Ortel, B. J., & Maytin, E. V. (2013) · Photonics and Lasers in Medicine · doi:10.1515/plm-2013-0047 · Cited by 1 · see citing works
Introduction to the laser journal
Arndt, K. A., & Rohrer, T. E. (2011) · Lasers in Surgery and Medicine · doi:10.1002/lsm.21050 · Cited by 1 · see citing works
Derpalyuk, E. N., Gladkova, N. D., Petrova, G. A., et al. (2005) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.634658 · Cited by 1 · see citing works
Anderson, R. R., & Kulesz-Martin, M. F. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.99 · Cited by 1 · see citing works
Trends in the treatment and detection of skin cancer.
Emer, J. J., & Markowitz, O. (2011) · PubMed · Cited by 1 · see citing works
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Wan, B., Ganier, C., Du‐Harpur, X., Harun, N., Watt, F. M., Patalay, R., & Lynch, M. D. (2021) · British Journal of Dermatology · doi:10.1111/bjd.19553 · Cited by 148 · see citing works
- Authors
- Cheng, H. M., & Guitera, P.
- Affiliations
- Melanoma Institute Australia (AU)
- The University of Sydney (AU)
- Corresponding author
- Cheng, H.M.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-10-27
- Volume
- 173
- Issue
- 6
- Pages
- 1371-1380
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2166168976
- Cited by
- 65
- References
- 56
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 6 · 2015: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- optical coherence tomography, basal cell carcinoma, diagnostic accuracy, treatment planning, treatment monitoring, non-invasive imaging, skin cancer diagnosis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell, Basal Cell Carcinoma, Humans, Male, Middle Aged, Sensitivity and Specificity, Skin Neoplasms, Observer Variation, Treatment Outcome, Tomography, Optical Coherence
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